A5000105938- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Biochemical and Molecular Research
- Enzyme Production and Characterization
- Antimicrobial agents and applications
- RNA and protein synthesis mechanisms
- Alkaline Phosphatase Research Studies
- Enzyme Structure and Function
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial Metabolic Engineering and Bioproduction
- Biotechnology and Related Fields
- Inhalation and Respiratory Drug Delivery
- Biochemical and Structural Characterization
- Animal Nutrition and Physiology
- Advanced oxidation water treatment
- Dermatology and Skin Diseases
- Blood properties and coagulation
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Acne and Rosacea Treatments and Effects
- Click Chemistry and Applications
- TiO2 Photocatalysis and Solar Cells
- Enzyme Catalysis and Immobilization
- Wound Healing and Treatments
Wrocław University of Science and Technology
2012-2023
AGH University of Krakow
2018-2023
Rega Institute for Medical Research
2020-2021
KU Leuven
2020-2021
Antibiotic overuse and mass production have led to a global problem with the treatment of antibacterial infections. Thus, any possibility limit number drugs used will contribute decrease in development pathogenic bacterial resistance. In this study, enhanced growth reduction pharmaceutical activated carbon (PAC) material adsorbed antimicrobial agents compared activity pure was investigated. Sulfamethoxazole (SMZ) at concentration 1.1 mg/mL retained S. aureus E. coli 20.5% 26.5%,...
Abstract Neutrophils are a type of granulocyte important in the “first line defense” innate immune system. Upon activation, they facilitate destruction invading microorganisms by production superoxide radicals, as well release enzymatic contents their lysozymes. These enzymes include specific serine proteases: cathepsin G, neutrophil elastase, proteinase 3, recently discovered protease 4 (NSP4). Under normal conditions, proteolytic activity proteases is tightly regulated endogenous serpins;...
Abstract Staphylococcus aureus is responsible for a variety of human infections, including life‐threatening, systemic conditions. Secreted proteome, range proteases, constitutes the major virulence factor bacterium. However, functions individual enzymes, in particular SplA protease, remain poorly characterized. Here, we report development specific inhibitors protease. The design, synthesis, and activity series α‐aminoalkylphosphonate diaryl esters their peptidyl derivatives are described....
S. aureus is the cause of many diseases, including numerous infections skin. One way to help combat skin use bandages containing activated carbon. Currently, there are no dressings on market that synergistic effect carbon and antibiotics. Thus, in this study, we point out adsorption level an antimicrobial substance three different active carbons origins; by examining inhibition growth bacteria, determined number live cells adsorbed depending presence gentamicin solution. In addition,...
The increasing problem of bacterial resistance to antibiotics underscores the urgent need for new antibacterials. Protein export pathways are attractive potential targets. Sec pathway is essential viability and includes components that absent from eukaryotes. Here, we used a high-throughput in vivo screen based on secretion activity alkaline phosphatase (PhoA), Sec-dependent secreted enzyme becomes active periplasm. assay was optimized luminescence-based substrate ~240K small molecule...
Abstract The increasing problem of bacterial resistance to antibiotics underscores the urgent need for new antibacterials. Sec preprotein export pathway is an attractive potential alternative target. It essential viability and includes components that are absent from eukaryotes. Here we used a high throughput in vivo screen based on secretion activity alkaline phosphatase (PhoA), Sec-dependent secreted enzyme becomes active periplasm. assay was optimized luminescence-based substrate ~240K...
Acesulfame K is a zero-calorie alternative to sugar used worldwide. There contradictory information on the toxicity of compound, but its accumulation in aquatic environment undeniable. In this study, one-pot sol-gel synthesis was obtain nitrogen-doped TiO2 photocatalysts. Doping up 6.29 wt % nitrogen caused an increase surface area catalysts (48.55–58.23 m2∙g−1) and reduction pHPZC value (5.72–5.05). photodegradation tested at initial concentration 20–100 ppm catalyst level 1 g∙L−1. Compared...