A5001231625- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Growth Hormone and Insulin-like Growth Factors
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Metabolism, Diabetes, and Cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Parasitic Diseases Research and Treatment
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Parasite Biology and Host Interactions
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Insect symbiosis and bacterial influences
- Cancer Diagnosis and Treatment
- Male Breast Health Studies
- Neuroendocrine Tumor Research Advances
Siriraj Hospital
2013-2023
Mahidol University
2012-2023
The University of Texas Health Science Center at San Antonio
2010
Molecular profiling of endometrial neoplasms reveals genetic changes in carcinomas that support the dualistic model, which type I are estrogen-dependent, low grade lesions and II nonestrogen dependent high grade. The molecular include mutations PTEN, PIK3CA, KRAS, beta-catenin, along with microsatellite instability, whereas characterized by alterations p53, HER2/neu, p16, E-cadherin. For a malignant mesenchymal component, C-MYC loss heterozygosity frequently seen carcinosarcomas, fusion...
We aimed to determine the rate of pathological complete response (pCR), clinicopathological factors associated with pCR, and clinical outcomes following neoadjuvant chemotherapy in locally advanced breast cancer.Medical records patients who had undergone for cancer between January 2007 September 2011 were retrospectively reviewed, pCR rates calculated according three sets criteria: National Surgical Adjuvant Breast Bowel Project (NSABP), MD Anderson Cancer Center (MDACC), German Group (GBG)....
Triple negative breast cancer (TNBC) is a subtype characterized by absence of both hormonal receptors and human epithelial growth factor receptor 2 (HER2). TNBC accounts for 15-20% cancer. associated with more aggressive disease worse clinical outcome. Though the underlying mechanism currently unclear, heterogeneity characteristics in various population may relate to difference tumor mutational profile. There were studies on gene mutations ethnic groups but genome data Thai patients unknown....
Abstract: Breast cancer patients do not commonly receive anti-estrogens prior to surgical excision. We reviewed a cohort of who received preoperative anti-estrogen therapy after baseline biopsy and then had repeat several weeks on treatment. Patients with estrogen receptor positive tumors anastrozole fulvestrant in combination gefitinib. Core needle biopsies were performed at day 1 21, completely excised if operable 112. All postmenopausal. Following treatment, degenerative changes including...
Prolactin (PRL) is a polypeptide hormone secreted by the anterior pituitary to stimulate growth and differentiation of normal mammary gland. Together with its receptor, prolactin receptor (PRLR) have been shown play role in breast cancer. This study aimed examine roles PRL PRLR polymorphisms expression cancer risk aggressiveness Thai patients.PRL (rs3756824 C/G rs2244502 T/A) (rs37364 G/T rs249537 A/G) were genotyped real-time PCR was assessed immunohistochemistry (IHC) tissues. The...
Breast cancer is the most frequent female malignancy in Thailand. Prolactin (PRL) and prolactin receptor (PRLR) play an important role normal breast development carcinogenesis of cancer. There are two major isoforms PRLR, consisting long-form (LF-PRLR) short-form (SF-PRLR) that stimulate different signaling pathways. This study aims to explore associations between all PRLR (all-PRLR) LF-PRLR with clinicopathological parameters patients.A total 340 patients were recruited from January 2009...
Objective: To find the incidence and prognosis of basal-like (TNB) non-basal-like (TNN) in triple negative breast cancer. Methods: Triple cancer (TN) cases were retrospectively reviewed biomarkers studied on tissue microarray for ER, PR, HER2, Ki67, basal cytokeratins (CK5/6, CK14, CK17), EGFR, CD117, p63, p53, vimentin, CK7, CK8/18, CK19, BCL2, p16, WT1, cyclin D1. The patients reclassified according to Ki67 index, CKs EGFR results into: lumA, lumB, HER2+, TNB TNN. Results: From 2007 2010,...
Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR non-luminal cancer remains inconclusive. The aim present study to evaluate clinical significance and its regulatory pathway subtypes In total, 284 patients were recruited from January 2007 2016. Tissue microarrays constructed archival paraffin blocks assessed for molecule, Lin28, by immunohistochemistry. association between Lin28 expression clinicopathological parameters analyzed....
Estrogen receptor positive breast cancers are commonly treated with anti‐estrogen therapy. However, little is known about the pathologic changes in after This study details histologic alterations of estrogen by anti‐estrogens combination gefitinib, an anti‐EGFR agent given to overcome endocrine resistance. tumors from 9 post‐menopausal women were studied. Patients received anastrazole, fulvestrant, and gefitinib for 4 months. Core needle biopsies performed at day 1 21, completely excised if...