A5046044440- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Advanced NMR Techniques and Applications
- Adipose Tissue and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- RNA regulation and disease
- Circular RNAs in diseases
- Amyotrophic Lateral Sclerosis Research
- GABA and Rice Research
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Nuclear Receptors and Signaling
- Pancreatic function and diabetes
McGill University
2019
Montreal Neurological Institute and Hospital
2019
Université de Montréal
2016
Dysregulation of miRNAs has been observed in many neurodegenerative diseases, including multiple sclerosis. Morquette et al. show that overexpression miR-223-3p prevents accumulation axonal damage a rodent model sclerosis, part through regulation glutamate receptor signalling. Manipulation miRNA levels may have therapeutic potential.
Physical activity improves glycemic control in type 2 diabetes (T2D), but its contribution to preserving β-cell function is uncertain. We evaluated the role of physical on secretory and glycerolipid/fatty acid (GL/FA) cycling male Zucker diabetic fatty (ZDF) rats. Six-week-old ZDF rats engaged voluntary running for 6 wk (ZDF-A). Inactive lean (ZDF-I) served as controls. ZDF-I displayed progressive hyperglycemia with failure evidenced by falling insulinemia reduced insulin secretion oral...