A5017927535- Carcinogens and Genotoxicity Assessment
- Safe Handling of Antineoplastic Drugs
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Advanced Chemical Sensor Technologies
- Effects and risks of endocrine disrupting chemicals
- Chemical Safety and Risk Management
- Analytical Chemistry and Chromatography
- Pesticide Exposure and Toxicity
- Pharmaceutical studies and practices
- Anesthesia and Sedative Agents
- Pancreatic and Hepatic Oncology Research
- Radical Photochemical Reactions
- Analytical chemistry methods development
- Pancreatitis Pathology and Treatment
- Metabolism and Genetic Disorders
- Coordination Chemistry and Organometallics
- Risk and Safety Analysis
- Mitochondrial Function and Pathology
- Occupational Health and Safety Research
- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Enzyme function and inhibition
University of Trento
2021
University of Bologna
2010-2020
Policlinico S.Orsola-Malpighi
2001-2019
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed both genetic and environmental factors. Indeed, the mtDNA background defined as haplogroup J known increase of 11778/ND4 14484/ND6 mutations. Recently it was also documented that professional exposure n-hexane might act an exogenous trigger for LHON. Therefore, we here investigate...
Seaports are complex systems in which workers can be exposed to a large variety of safety and health risks. Nevertheless, little literature is available concerning this topic, if we exclude the specific area shipbuilding industry.Objectives. The aim paper update review scientific previously published as result project occupational risks seaports.Methods. Literature on theme, obtained consulting main databases (PubMed, Scholar CCOHS) from 2012 up April 2019, was reviewed.Results. Five eight...
Abstract The aim of this study was to develop and validate a novel solid‐phase extraction (SPE) liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination two antineoplastic drugs, cyclophosphamide (CP) methotrexate (MTX), in human urine using trophosphamide as internal standard. showed good precision accuracy (mean RSD 2.8% 0.9%; bias 2.7% 2.4% MTX CP, respectively). lower limits detection obtained, 0.2 µg/L 0.04 were than best previously reported...
A new high-performance liquid chromatographic/electrospray ionization tandem mass spectrometric (HPLC/ESI-MS/MS) method was developed for the simultaneous quantification of 5-fluorouracil (5FU), methotrexate (MTX) and cyclophosphamide (CP) in environmental samples. These compounds, commonly used treatment cancer, are recognized as genotoxic. In order to estimate occupational exposure hospital personnel handling these drugs, wipe samples were taken from working surfaces directly analyzed...
Abstract Measurable levels of anticancer agents are still detected on work surfaces in health‐care settings. However, application recent guidelines for the protection workers' safety and health has resulted lowered contamination levels. To assess occupational exposure to antineoplastic agents, very sensitive specific procedures environmental sampling analysis therefore needed. In present study an assay simultaneous determination gemcitabine, taxol, cyclophosphamide, ifosfamide wipe samples,...
The urinary excretion of t,t-muconic acid (t,t-MA), S-phenylmercapturic (SPMA) and benzene the influence a smoking habit exposure to urban traffic on these biomarkers were investigated in 137 male adults from general population. All subjects not occupationally exposed resident two cities Puglia (Southern-Italy). Environmental was measured using passive personal samplers. t,t-MA, SPMA determined urine samples collected each subject at end environmental sampling. percentage cases above limit...
Abstract 8‐Hydroxy‐2′‐deoxyguanosine (8OHdG), one of the major oxidative DNA lesions induced by radical agents, is commonly used as a biomarker for stress, nowadays preferably in urine. In absence commercially available internal standard micro‐high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (micro‐HPLC/ESI‐MS/MS) method, suitable routine analysis 8OHdG human urine using external calibration, was developed. Evaluation matrix effect showed that method...
Abstract Background Some industrial hygiene studies have assessed occupational exposure to antineoplastic drugs; other epidemiological investigations detected various toxicological effects in groups labeled with the job title. In no research has same population been studied both environmentally and epidemiologically. The protocol of study presented here uses an integrated environmental biological monitoring approach. aim is assess hospital nurses preparing and/or administering therapy cancer...
Abstract We describe a rapid and sensitive high‐performance liquid chromatography/electrospray tandem mass spectrometry (HPLC/ESI‐MS/MS) method for simultaneous determination of the most relevant metabolites benzene toluene, t,t‐ muconic acid ( t,t ‐MA), S ‐phenylmercapturic (S‐PMA), ‐benzylmercapturic (S‐BMA). Urine samples were purified before analysis by solid‐phase microextraction (SPE) on SAX cartridges with 50 mg sorbent mass. The developed fulfils all standard requirements precision...
DNA damage and cellular repair capacity were studied in 18 male fuel tanker drivers 13 filling-station attendants exposed to low very concentrations of benzene, respectively, compared 20 males with no occupational exposure (controls). Exposure airborne benzene was measured using passive personal samplers, internal doses assayed through the biomarkers t,t-muconic acid, S-phenylmercapturic acid urinary benzene. evaluated tail intensity (TI) determined by comet assay peripheral lymphocytes....