A5061673361- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Cancer Treatment and Pharmacology
- Metabolism, Diabetes, and Cancer
- HER2/EGFR in Cancer Research
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Inflammatory mediators and NSAID effects
Leiden University Medical Center
2018-2023
Hubrecht Institute for Developmental Biology and Stem Cell Research
2014
University Medical Center Utrecht
2014
Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 secretion L-cell abundance. Here we identify G-protein–coupled bile acid receptor (GPBAR1) as a selective regulator intestinal differentiation. Lithocholic the synthetic GPBAR1 agonist, L3740, selectively increased density mouse human organoids elevated secretory capacity. L3740 induced expression Gcg transcription factors...
Glucagon-like peptide-1–based (GLP-1–based) therapies improve glycemic control in patients with type 2 diabetes. While these agents augment insulin secretion, they do not mimic the physiological meal-related rise and fall of GLP-1 concentrations. Here, we tested hypothesis that increasing number intestinal L cells, which produce GLP-1, is an alternative strategy to responses glucose tolerance. Blocking NOTCH signaling pathway γ-secretase inhibitor dibenzazepine increased cells organoid–based...
Essentials•Factor Xa (FXa)‐targeting direct oral anticoagulants (DOACs) reduce venous thromboembolism (VTE)•The effects of FXa‐targeting DOACs on cancer progression remain to be studied•In xenograft models, a DOAC did not inhibit breast growth and metastasis•A thrombin‐targeting DOAC, dabigatran, also metastasisAbstract Background:Factor Xa‐targeting were recently found recurrent VTE efficiently in patients when compared the standard treatment with low‐molecular‐weight heparins (LMWHs)....
Cancer enhances the risk of venous thromboembolism, but a hypercoagulant microenvironment also promotes cancer progression. Although anticoagulants have been suggested as potential anticancer treatment, clinical studies on effect such modalities progression not yet successful for unknown reasons. In normal physiology, complex formation between subendothelial-expressed tissue factor (TF) and blood-borne liver-derived VII (FVII) results in induction extrinsic coagulation cascade intracellular...
Bleeding disorders and thrombotic complications are major causes of morbidity mortality with many cases being unexplained. Thrombus formation involves aberrant expression activation tissue factor (TF) in vascular endothelial smooth muscle cells. Here, we sought to identify factors that modulate TF gene activity these The LIM-only protein FHL2 is a scaffolding modulates signal transduction pathways crucial functions However, the role regulation thrombosis remains unexplored. Using murine...