A5091884432- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Protease and Inhibitor Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac and Coronary Surgery Techniques
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood transfusion and management
- Chronic Lymphocytic Leukemia Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Multiple Myeloma Research and Treatments
- Case Reports on Hematomas
- Neurological Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
Faculdade de Ciências Médicas de Minas Gerais
2015-2024
Brazilian Medical Association
2021
Lifecenter Hospital
2019
Clinica Universidad de Navarra
1997-2017
Grupo Santa Casa de Belo Horizonte
2015
Universidad de Navarra
2003-2013
Hospital de Santa Cruz
2003-2010
Agencia Española de Medicamentos y Productos Sanitarios
2009
Universidade Federal de Minas Gerais
2008
Laboratorios Farmaceúticos Rovi (Spain)
2004
Fibrinogen, euglobulin lysis time (ELT), tissue-type plasminogen activator (t-PA) antigen, inhibitor activity (PA-inhibitor) and alpha 2-antiplasmin (alpha 2-AP) were measured pre- postoperatively in 60 patients undergoing total hip replacement. Reduced fibrinolytic as assessed by the prolongation of time, decrease t-PA increase PA-inhibitor 2-AP could be demonstrated. These changes did not correlate with postoperative deep vein thrombosis (DVT) diagnosed 125I-fibrinogen test. However,...
It has been suggested that desmopressin acetate (DDAVP) administration reduces blood loss after cardiac surgery. We have investigated the effect of DDAVP in a double-blind, randomized, prospective trial including 100 patients placed on cardiopulmonary bypass during Fifty received 0.3 micrograms/kg and 50 placebo administered ml saline solution over 15 min when had concluded. Results showed no significant differences either total per square meter (458 +/- 206 group vs 536 304 group) or...
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The influence of cardiopulmonary bypass (CPB) on fibrinolytic activity was assessed in 100 patients with valvular heart disease or atrial septal defects. Euglobulin (EFA), tissue type plasminogen activator (t-PA) activity, inhibitor 1 (PAI-1) plasminogen, alpha 2-antiplasmin (alpha 2-AP), fibrinogen degradation products (FDP), and D-dimer were measured pre-, intra-, postoperatively. There significant increases EFA t-PA (p less than 0.002), decreases 2-AP 0.0001) intraoperatively respect to...
Patients on cardiopulmonary bypass (CPB) have an increased susceptibility to postoperative bleeding. Previous reports using desmopressin acetate (DDAVP) for the prevention of bleeding given contradictory results, whereas protease inhibitor aprotinin has been shown reduce blood loss after this type surgery. This randomized study was performed assess efficacy DDAVP versus in CPB.One hundred nine 122 eligible patients were four different groups: Group A (n = 28) received starting with a bolus 2...
We studied the fibrinolytic response before and after venous occlusion (VO) in 30 patients with systemic lupus erythematosus (SLE), 25 rheumatoid arthritis (RA) different connective tissue disorders. Results were compared without antiphospholipid antibodies (APA) a history of either thrombosis or abortions. Before plasma levels tissue-type plasminogen activator (t-PA) antigen its inhibitor (PAI-1) significantly higher patient group (p < 0.001). After occlusion, low activity on fibrin plates...
It has been experimentally shown that endotoxin induces a marked increase in the levels of fast-acting inhibitor plasminogen activator (PAI). The plasma PAI activity and tissue-type (t-PA) concentrations were measured 61 patients with human septicaemia results compared those observed healthy controls. There was markedly significant platelet extracts as to controls (p less than 0.0001). No correlation between concentration observed. Fibrin autography samples confirmed inhibition associated...
Clinical and laboratory variables were measured on the day before operation in 111 patients who underwent total hip replacement prophylactically treated with acetylsalicylic acid or heparin-dihydroergotamine. Postoperative deep vein thrombosis (DVT) was detected 16 by ascending venography. Stepwise logistic discriminant analysis used to identify DVT predicting factors. Three such factors, fibrinogen degradation products (FDP), plasminogen activator inhibitor (PA-inhibitor) tissue type...
Plasmin–α 2 ‐antiplasmin complexes (PAP) are considered good markers of fibrinolytic activation in vivo . The presence neoantigens these offers the possibility to develop specific immunoassays determine PAP levels. We have developed a sensitive purification method vitro by adding urokinase fresh plasma followed affinity chromatography lysine‐sepharose and elution with ε‐aminocaproic acid. This material, characterized SDS‐PAGE Western blotting, was used raise monoclonal antibodies (MoAbs)....
Evaluations of the effectiveness multifaceted suicide prevention programmes often focus exclusively on primary outcome measures, such as and non-fatal suicidal acts. In order to build evidence for it is therefore important also include intermediate which review presented. Intermediate measures are defined proximal effect indicators single interventions multi-level directly linked objectives content each intervention. A literature was conducted studies including papers addressing psychometric...
Summary Plasminogen activator inhibitor-1 (PAI-1) increases in endotoxemia thus possibly cooperating altering the hemostatic balance a prothrombotic direction. The effect of inhibition PAI-1 with monoclonal antibody MA-33B8 was studied systemically and kidneys lapine model endotoxin-induced disseminated intravascular coagulation (DIC). increase plasmatic PAI activity control group (n = 9) inhibited treated rabbits 5). Control showed renal fibrin deposits, whereas only one did so. These...