A5101583029- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Plant Ecology and Soil Science
- Plant biochemistry and biosynthesis
- Neurobiology and Insect Physiology Research
- Chromosomal and Genetic Variations
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Behavior and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Arachnid Ecology and Behavior
- Forest Insect Ecology and Management
- Plant and animal studies
- Physiological and biochemical adaptations
- CRISPR and Genetic Engineering
- Environmental Toxicology and Ecotoxicology
- Biochemical and biochemical processes
- Plant Gene Expression Analysis
- Species Distribution and Climate Change
- Plant Virus Research Studies
- Identification and Quantification in Food
- GABA and Rice Research
- Genetics and Physical Performance
- Insect Utilization and Effects
Chinese Academy of Sciences
2021-2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Anhui Mental Health Center
2024
Northwest Institute of Eco-Environment and Resources
2021-2024
Anhui Agricultural University
2024
Beijing Forestry University
2017-2023
North Carolina State University
2010-2023
Guangzhou University of Chinese Medicine
2023
State Key Laboratory of Tree Genetics and Breeding
2023
Abstract Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly Rhododendron simsii , primary ancestor azalea cultivars. Genome analyses unveil remnants an ancient whole-genome duplication preceding radiation Ericaceae, likely contributing to genomic architecture flowering time. Small-scale gene duplications contribute expansion families involved in pigment biosynthesis....
Phenotypic plasticity is the ability of a single genotype to produce different phenotypes in response changing environments. We assessed variation genome-wide gene expression and four fitness-related an outbred Drosophila melanogaster population under 20 physiological, social, nutritional, chemical, physical environments; we compared phenotypically plastic transcripts genetically variable environment. The environmentally sensitive transcriptome consists two transcript categories, which...
For most organisms, chemosensation is critical for survival and mediated by large families of chemoreceptor proteins, whose expression must be tuned appropriately to changes in the chemical environment. We asked whether genes that are clustered genome would regulated independently; certain especially sensitive environmental changes; groups undergo coordinated rexpression; how plastic with regard sex, development, reproductive state, social context. To answer these questions we used...
A major challenge in modern biology is to understand how naturally occurring variation DNA sequences affects complex organismal traits through networks of intermediate molecular phenotypes. This question best addressed a genetic mapping population which all polymorphisms are known and for endophenotypes assessed on the same genotypes. Here, we performed deep RNA sequencing 200
The genetic factors that give rise to variation in susceptibility environmental toxins remain largely unexplored. Studies on are challenging human populations, due the variety of clinical symptoms and difficulty determining which causally result from toxic exposure; uncontrolled environments, often with exposure multiple toxicants; relating phenotypic effect size dose, especially when become manifest a substantial time lag. Drosophila melanogaster is powerful model enables genome-wide...
Abstract Polyploidization plays a key role in plant evolution, but the forces driving fate of homoeologs polyploid genomes, i.e., paralogs resulting from whole-genome duplication (WGD) event, remain to be elucidated. Here, we present chromosome-scale genome assembly tetraploid scarlet sage ( Salvia splendens ), one most diverse ornamental plants. We found evidence for three WGD events following an older event shared by eudicots (the γ event). A comprehensive, spatiotemporal, genome-wide...
Lead toxicity presents a worldwide health problem, especially due to its adverse effects on cognitive development in children. However, identifying genes that give rise individual variation susceptibility lead is challenging human populations.Our goal was use Drosophila melanogaster identify evolutionarily conserved candidate associated with exposure.To toxicity, we measured of exposure time, viability and adult activity the Genetic Reference Panel (DGRP) performed genome-wide association...
Sour or wild jujube fruits and dried seeds are popular food all over the world. In this study, we reported a high-quality genome assembly of sour (
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Natural populations harbor considerable genetic variation for lifespan. While evolutionary theory provides general explanations the existence of this variation, our knowledge genes harboring naturally occurring polymorphisms affecting lifespan is limited. Here, we assessed divergence between five Drosophila melanogaster lines selected postponed senescence over 170 generations (O lines) and from same base population maintained at a two week generation interval 850 (B lines). On average, O...
Phenotypic plasticity allows organisms to respond rapidly changing environmental circumstances, and understanding its genomic basis can yield insights regarding the underlying genes genetic networks affecting complex phenotypes. Female Drosophila melanogaster undergo dramatic physiological changes mediated by seminal fluid components transferred upon mating, including decreased longevity. Their behavioral effects have been well characterized, but little is known about resulting in regulation...
Abstract LTR retrotransposons (LTR-RTs) are ubiquitous and represent the dominant repeat element in plant genomes, playing important roles functional variation, genome plasticity evolution. With advent of new sequencing technologies, a growing number whole-genome sequences have been made publicly available, making it possible to carry out systematic analyses LTR-RTs. However, comprehensive unified annotation LTR-RTs groups is still lacking. Here, we constructed intact dataset, which designed...
Terpenes and terpenoids are key natural compounds for plant defense, development, composition of oil. The synthesis accumulation a myriad volatile terpenoid in these plants may dramatically alter the quality flavor oils, which provide great commercial utilization value oil-producing plants. Terpene synthases (TPSs) important enzymes responsible terpenic diversity. Investigating differentiation TPS gene family could valuable theoretical support genetic improvement While origin function genes...
The extent to which epistasis affects the genetic architecture of complex traits is difficult quantify, and identifying variants in natural populations with epistatic interactions challenging. Previous studies Drosophila implicated extensive between genes that affect neural connectivity contribute variation olfactory response benzaldehyde. In this study, we implemented a powerful screen quantify as well identify candidate interacting using 203 inbred wild-derived lines sequenced genomes...
How effects of DNA sequence variants are transmitted through intermediate endophenotypes to modulate organismal traits remains a central question in quantitative genetics. This problem can be addressed systems approach population which genetic polymorphisms, gene expression traits, metabolites, and complex phenotypes evaluated on the same genotypes. Here, we focused metabolome, represents most proximal link between variation phenotype, quantified metabolite levels 40 lines Drosophila...
Climate niche modeling has been widely used to assess the impact of climate change on forest trees at species level. However, geographically divergent tree populations are expected respond differently change. Considering intraspecific local adaptation in responses will thus improve credibility and usefulness models, particularly for genetic resources management. In this study, we five Platycladus orientalis (L.) seed zones (Northwestern; Northern; Central; Southern; Subtropical) covering...
Knowledge about the local adaptation and response of forest tree populations to climate is important for assessing impact change developing adaptive genetic resource management strategies. However, such information not available most plant species. Here, based on 69 provenances tested at 19 common garden experimental sites, we developed a universal function (URF) height seven years age wide-spread native Chinese species Platycladus orientalis (L.) Franco. URF was recently used predict...
Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using full diallel cross 50 Drosophila Genetic Reference Panel inbred lines with whole genome sequences, we found substantial variation in fertility largely attributable to females. We mapped genes associated female by genome-wide association analysis common variants the fly genome. Validation candidate RNAi knockdown confirmed role dopamine 2-like receptor ( Dop2R ) promoting egg laying....
Summary Background Peroxisome proliferator‐activated receptor γ inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 this gene (Pro12Ala) has been shown to confer protection against diabetes colorectal cancer. Aim To study association between peroxisome polymorphism, Helicobacter pylori infection in Chinese. Methods One hundred four consecutive patients with non‐cardia adenocarcinoma 104 matched controls were examined. Pro12Ala was analysed by...
Abstract In plants, ultraviolet (UV)-light is an important driver for growth and natural distribution, also a valuable tool manipulating productivity as well biotic interactions. Understanding of plant responses to different UV radiation sparse, especially from systems biology perspective particularly conifers. Here, we evaluated the physiological transcriptomic short-term application high-irradiance UV-B UV-C waves on Pinus tabuliformis Carr., major conifer in Northern China. By undertaking...
Natural selection is a significant driver of population divergence and speciation plants. Due to local adaptation geographic regions with ecological gradients, plant populations harbored wide range adaptive genetic variation enable them survive the heterogeneous habitats. This all more necessary for desert plants, as they must tolerant striking gradients abiotic stresses. However, genomic mechanism by which plants adapt heterogeneity remains unclear, could help guide sustainability...
Background: Alzheimer’s disease (AD) is a neurodegenerative characterized by brain network dysfunction. Few studies have investigated whether the functional connections between executive control networks (ECN) and other regions can predict therapeutic effect of repetitive transcranial magnetic stimulation (rTMS). Objective: The purpose this study to examine relationship connectivity (FC) within ECN efficacy rTMS. Methods: We recruited AD patients for rTMS treatment. established an using...
Pollination dynamics was studied in a first-generation Platycladus orientalis (L.) Franco seed orchard with pedigree reconstruction using eight nuclear and four chloroplast SSRs. The assigned 371 of 448 seeds to one the orchard’s 192 candidate male parents showed high level outcrossing pollen contamination crop. While population greater allelic richness compared parental population, few alleles present were missing Additionally, we detected no significant correlation between reproductive...