A5075132991- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- Image Processing Techniques and Applications
- Digital Holography and Microscopy
- Metaheuristic Optimization Algorithms Research
- Evolutionary Algorithms and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Vagus Nerve Stimulation Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aerodynamics and Acoustics in Jet Flows
- Genomics and Phylogenetic Studies
- Neural Networks and Applications
- Protein Structure and Dynamics
- Molecular Communication and Nanonetworks
- Statistical Methods and Inference
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Tactile and Sensory Interactions
- Immune Response and Inflammation
- Advanced Battery Technologies Research
- Interactive and Immersive Displays
- Bacterial Identification and Susceptibility Testing
- Consumer Perception and Purchasing Behavior
- Robotic Locomotion and Control
- Genetic Associations and Epidemiology
Chungnam National University
2024
Sungkyunkwan University
2014-2024
Statistics Korea
2024
Korea University
2024
Seoul National University
2009-2024
Hongik University
2021
Australian National University
2021
Carnegie Mellon University
2021
Water Research Institute
2021
LG (United States)
2021
A synergistic application of holography and deep learning enables rapid optical screening anthrax spores other pathogens.
Identification of lymphocyte cell types are crucial for understanding their pathophysiological roles in human diseases. Current methods discriminating primarily rely on labelling techniques with magnetic beads or fluorescence agents, which take time and have costs sample preparation may also a potential risk altering cellular functions. Here, we present the identification non-activated at single-cell level using refractive index (RI) tomography machine learning. From measurements...
Traditional monoclonal antibodies such as Trastuzumab encounter limitations when treating Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer, particularly in cases that develop resistance. This study introduces plant-derived anti-HER2 variable fragments of camelid heavy chain domain (VHH) fragment crystallizable region (Fc) KEDL(K) antibody a potent alternative for overcoming these limitations. A variety biophysical techniques, vitro assays, and vivo experiments uncover...
Abstract Homeostasis of neutrophils—the blood cells that respond first to infection and tissue injury—is critical for the regulation immune responses regulated through granulopoiesis, a multi-stage process by which neutrophils differentiate from hematopoietic stem cells. Granulopoiesis is highly dynamic altered in certain clinical conditions, such as pathologic iatrogenic neutropenia, described demand-adapted granulopoiesis. The granulopoiesis under stress not completely understood because...
Rapid identification of bacterial species is crucial in medicine and food hygiene. In order to achieve rapid label-free at the single bacterium level, we propose experimentally demonstrate an optical method based on Fourier transform light scattering (FTLS) measurements statistical classification. For individual rod-shaped bacteria belonging four (Listeria monocytogenes, Escherichia coli, Lactobacillus casei, Bacillus subtilis), two-dimensional angle-resolved maps are precisely measured...
Shiga toxin-producing Escherichia coli (STEC) infects humans by colonizing the large intestine, and causes kidney damage secreting toxins (Stxs). The increased secretion of toxin 2 (Stx2) some antibiotics, such as ciprofloxacin (CIP), increases risk hemolytic-uremic syndrome (HUS), which can be life-threatening. However, previous studies evaluating this relationship have been conflicting, owing to low frequency EHEC infection, very small number patients, lack an appropriate animal model. In...
Human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contribute to both and gastrointestinal symptoms, necessitating a comprehensive approach studying viral pathogenesis. In this context, bioprinted intestine-on-chip models offer cutting-edge technology for closely replicating the tissue architecture microenvironment of human intestine, providing valuable insights into dynamics host responses. Integration intestinal organoids with organoid-on-chip...
As whole genome sequencing (WGS) uncovers variants associated with rare and common diseases, an immediate challenge is to minimize false-positive findings due variant calling errors. False positives can be reduced by combining results from orthogonal methods, but costly. Here, we present filtering approaches using logistic regression (LR) ensemble genotyping false without sacrificing sensitivity. We evaluated the methods paired WGS datasets of extended family prepared two platforms a...
Shin et al [19] and McKay [15] previously applied tree compression semantics-based simplification to study the distribution of building blocks in evolving Genetic Programming populations. However their method could only give static estimates degree repetition one generation at a time, supplying no information about flow between generations. Here, we use state-of-the-art algorithm, xmlppm, estimate extent which frequent from are still later generation. While they compared behaviour different...
Abstract Establishing early warning systems for anthrax attacks is crucial in biodefense. Here we present an optical method rapid screening of Bacillus anthracis spores through the synergistic application holographic microscopy and deep learning. A convolutional neural network designed to classify images unlabeled living cells. After training, outperforms previous techniques all accuracy measures, achieving single-spore sensitivity sub-genus specificity. The unique ‘representation learning’...
Abstract Recently, the atomic structures of both closed and open forms Group 2 chaperonin protein Mm‐cpn were revealed through crystallography cryo‐electron microscopy. This toroidal‐like is composed two eightfold rings that face back‐to‐back. To gain a computational advantage, we used symmetry constrained elastic network model (SCENM), which requires only repeated subunit structure its symmetric connectivity to neighboring subunits simulate entire system. In case chaperonin, six (i.e.,...
A pump-jet propeller is composed of a rotor, stator, and duct. pre-swirl stator employed to optimize flow into the rotor. The hydrodynamic noise performances propellers vary with angles. In this study, performance full-scale submarine assessed by conducting computational fluid dynamics simulations based on Reynolds-averaged Navier–Stokes equation. Additionally, broadband noise, blade-passing frequency significant factor, that is, underwater radiated are predicted using Lighthill’s equation,...