A5056728269- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Mosquito-borne diseases and control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Viral Infections and Vectors
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 and healthcare impacts
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- Hematological disorders and diagnostics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacterial Identification and Susceptibility Testing
- Vascular Tumors and Angiosarcomas
- Economic and Financial Impacts of Cancer
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
All India Institute of Medical Sciences
2018-2025
All India Institute of Medical Sciences Bhopal
2018-2023
All India Institute of Medical Sciences Raipur
2018-2023
Max Healthcare
2023
Creative Commons
2023
National Institute of Medical Statistics
2023
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2023
Institute of Medical Sciences
2023
University Hospitals Bristol NHS Foundation Trust
2017
Post Graduate Institute of Medical Education and Research
2016
Background Mesenchymal stem cells (MSCs) mediate immunomodulation through various mechanisms, including apoptosis, efferocytosis, and mitochondrial transfer. Our study investigates the impact of hypoxia preconditioning on immune metabolic reprogramming immunomodulatory potential MSCs in acute graft-versus-host disease (aGVHD). Additionally, we explored differential effects tissue-specific MSCs, specifically bone marrow (BM) Wharton Jelly (WJ), elucidated mechanisms underlying variability...
This study describes a new approach for assessing behavioral changes following toxicant exposure and compares the method to other common endpoints used in environmental toxicology. The nematode Caenorhabditis elegans was exposed range of ethanol concentrations determine its effect on survival, reproduction behavior. Each endpoint evaluated sensitivity by comparing LC50, RC50 (concentration at which there is 50% reduction number offspring as compared controls), BC50 movement controls) values...
A breakdown of the blood-brain barrier occurred in mice inoculated intracerebrally (i.c.) or intraperitoneally (i.p.) with dengue virus type 2 (DEN2). This resulted leakage protein-bound Evans blue dye and 51Cr-labelled erythrocytes into brain tissue. The increased time after infection coincided an increase a DEN2-induced cytokine, cytotoxic factor (CF), spleens such mice. titres exponentially i.c. but was not detected brains given DEN2 by i.p. route. Similar also intravenously CF; damage...
PURPOSE: Patients who undergo allogeneic hematopoietic stem-cell transplantation (allo-HSCT) usually require a prolonged hospital stay that varies greatly across patients. Limited information exists on the factors associated with length of (LOS) after allo-HSCT and impact transplant-related costs. The objective this study was to determine predictors for longer LOS assess their cost transplant stay. METHODS: Using National Inpatient Sample database, adult patients hospitalized were identified...
ABSTRACT Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disorder characterized by vasculopathy, immunodeficiency, and hematological abnormalities. Its presentation as infantile pure red cell aplasia (PRCA) often mimics Diamond Blackfan anemia (DBA), leading to diagnostic delays suboptimal management. This study retrospectively analyzed nine cases DADA2‐related PRCA diagnosed over 5 years at tertiary care hospital. All patients harbored homozygous ADA2 mutations,...
Abstract Background Acute Graft-versus-Host-Disease (aGvHD) is a major immune complication following allogenic hematopoietic stem cell transplantation (Allo-HSCT), initiated by conditioning regimen-associated tissue damage. It involves the complex interplay of cells and cytokines. Our study aims to leverage machine learning (ML) algorithms on cytokine profile Allo-HSCT recipients develop biomarker-based classification models predict onset aGvHD at time engraftment. Materials Methods Seventy...
ABSTRACT Introduction: Because of its functional and cosmetic importance, facial injuries, especially bony fractures are clinically very significant. Missed maltreated might result in malocclusion disfigurement the face, thus making accurate diagnosis fracture essential. In earlier times, conventional radiography along with clinical examination played a major role maxillofacial fractures. However, it was noted that overlapping nature bones inability to visualise soft tissue swelling...
: We report a 14-year-old girl who presented with subdural hematoma and deranged coagulation profile suggestive of an inhibitor. Investigations revealed prothrombin deficiency along positivity for antiphospholipid antibodies, which improved steroid therapy. Bleeding diathesis in children adolescents commonly results from thrombocytopenia, platelet function disorders, or factor deficiency; whereas bleeding because inhibitors are extremely rare this age group. This case also highlights the...
HBsAg was screened by Reverse Passive Haemagglutination Test (RPHA) and confirmed ELISA test in 157 pregnant females their newborns. Anti-HBc IgM anti-HBc done these cases enzyme immuno-assay. The overall prevalence of mothers 16 out (10 percent) cord blood newborns 5 per cent transplacental transmission found eight (50 cent) positive mothers. present 12 (75 and, these, seven (58 neonates acquired infection. (88 neonates, suggesting active utero Fourteen born to were alive healthy, one...
Despite improvements in leukemia therapy, acute myeloid (AML) remain a difficult disease to treat with majority of patients having relapse without an allogeneic stem cell transpl...
The study was designed to review the demographic, clinical, and pathologic characteristics of follicular helper T cells (TFH)-derived nodal PTCL in India including angioimmunoblastic T-cell lymphoma (AITL), peripheral (PTCL) with cell phenotype (P-TFH), additional immunohistochemistry (IHC) RHOAG17V mutational analysis, as well their impact on survival. This retrospective included 88 cases that were reclassified using IHC for TFH markers (PD1, ICOS, BCL6, CD10) dendritic-meshwork (CD21,...
Mesenchymal stem cells (MSCs) have emerged as promising candidates for immune modulation in various diseases that are associated with dysregulated responses like Graft-versus-Host-Disease (GVHD). MSCs pleiotropic and the fate of following administration is a major determinant their therapeutic efficacy. Human were derived from bone marrow (BM) Wharton's Jelly (WJ) preconditioned through exposure to hypoxia induction apoptosis, either sequentially or simultaneously. The programming potential...
During dengue type 2 virus (DV) infection of mice a unique cytokine, the cytotoxic factor (CF), is produced which reproduces pathological lesions seen in patients haemorrhagic fever (DHF). Recently we have observed CF-like protein sera DHF cases. The present study was undertaken to investigate whether DV can stimulate human peripheral blood mononuclear cells (PBMC) vitro produce CF (hCF). Cultures prepared from PBMC or its enriched subpopulations were inoculated with 1000 LD50 and controls...
SUMMARY Dengue type 2 virus (DV)-induced cytotoxic factor (CF) is capable of reproducing various pathological lesions in mice that are seen human dengue. The present study was undertaken to investigate the protective effect active immunization with CF, Mice were immunized 5 μg CF and prevention CF-induced increase capillary permeability damage blood brain barrier studied at weekly intervals, up 48 weeks, by challenging 3 Maximum protection against blood-brain observed week 4 after...
Dizziness and vertigo are frequently reported by patients with migraine. In migrainous (MV), is causally related to Patients of MV usually have an attenuated or absent headache their as compared usual Here we report three female in which administration triptan was associated induction (two patients) exacerbation (one patient) disappearance vertigo. We suggest that migraine may be inversely each other suppression one induce aggravate the other.
The Coronavirus disease-19 (COVID-19) pandemic has in multiple ways affected healthcare delivery to non−COVID patients throughout the world. Adequate transfusion services are fundamental ongoing therapy of with hematological ailments. We present hematology daycare under department Hematology and supported by Blood Bank at our institution for period 12th April 2020−30th June 2020, which saw stringent lockdown unlocking Phase I India, declared lieu pandemic. A 56 % reduction total sessions was...