A5015859086- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Photochromic and Fluorescence Chemistry
- Advanced Nanomaterials in Catalysis
- Supramolecular Chemistry and Complexes
- Advanced Fluorescence Microscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- melanin and skin pigmentation
- Click Chemistry and Applications
- Biochemical Analysis and Sensing Techniques
- Photoacoustic and Ultrasonic Imaging
- RNA and protein synthesis mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- DNA and Nucleic Acid Chemistry
Korea University
2017-2021
Seoul Institute
2017
A two-photon fluorescent probe (<bold>Tyro-1</bold>) can validate intracellular tyrosinase activity, and H<sub>2</sub>O<sub>2</sub>induced upregulated in melanoma cells.
Abstract Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia‐induced inflammation, tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on zirconium carbide (ZrC)...
Melanoma is the most threatening form of metastatic skin cancer that develops from melanocytes and causes a large majority deaths due to poor therapeutic prognosis. It has significant limitations in treatment because it shows great resistance chemotherapy, radiotherapy, other methods. A noninvasive clinically accepted modality, photodynamic therapy (PDT), promising option, but limitedly applied for melanoma treatment. This photosensitizers are unlikely be expected have remarkable effect on...
One of the recent advances in nanotechnology within medical field is development a nanoformulation anticancer drugs or photosensitizers. Cancer cell-specific drug delivery and upregulation endogenous level reactive oxygen species (ROS) are important precision treatment. Within our article, we report new therapeutic cancer cell targeting using ROS self-generation without an external initiator switch-on release (ROS-induced cascade nanoparticle degradation generation). We found substantial...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Nov 2021Fluorescent Visualization of Nucleolar G-Quadruplex RNA and Dynamics Cytoplasm Intranuclear Viscosity Le Yu†, Peter Verwilst†, Inseob Shim, Yu-Qiang Zhao, Ying Zhou Jong Seung Kim Yu† College Chemical Science Technology, Yunnan University, Kunming 650091 Department Chemistry, Korea Seoul 02841 †L. Yu P. Verwilst contributed equally to this work.Google Scholar More articles by author , Verwilst† KU Leuven, Rega Institute for Medical Research,...
We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5'-DFUR. The release from the prodrug BDDS can be achieved upon its reaction intracellular H2O2, overexpressed in cancer cells. efficacy of was demonstrated by comparative study along that single conjugate (SDDS), bearing alone.