A5014103198- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Congenital Anomalies and Fetal Surgery
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Hangzhou First People's Hospital
2024
Zhejiang University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2023
Qinghai University Affiliated Hospital
2022
The function of SLC7A11 in the process ferroptosis is well-established, as it regulates synthesis glutathione (GSH), thereby influencing tumor development along with drug resistance non-small cell lung cancer (NSCLC). However, determinants governing SLC7A11's membrane trafficking and localization remain unknown. Our study identified SPTBN2 a suppressor, enhancing NSCLC cells to inducers. Mechanistically, SPTBN2, through its CH domain, interacted connected motor protein Arp1, thus...
Alveolar Echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis, but its pathogenesis remains unclear. The primary objective of this study to explore whether multilocularis protoscoleces (PSCs) regulate macrophage polarization and glucose metabolism PI3K/Akt/mTOR signaling pathway. We found that large numbers CD68+ macrophages gathered in close liver issue from the lesion AE patients. PSCs preferentially differentiated into M2 expressions HK1, PFKL, PKM2,...
Abstract Background: Alveolar Echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis , but its pathogenesis remains unclear. The primary objective of this study to explore whether protoscoleces (PSCs) regulate macrophage polarization and glucose metabolism PI3K/Akt/mTOR signaling pathway. Methods: Macrophage were analyzed flow cytometry, PI3K, Akt, pAKT, mTOR detected western blot, cell metabolic was seahorse. Results: Large numbers CD68 + macrophages...