A5045914545- Virology and Viral Diseases
- Respiratory viral infections research
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Yersinia bacterium, plague, ectoparasites research
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Viral Infections and Vectors
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2015-2020
The anticholinergic anti-parkinsonism drug Norakin is an inhibitor of influenza virus multiplication. By crossing a Norakin-resistant variant fowl plague (FPV) strain Weybridge with the sensitive FPV/Rostock/34 wild-type virus, recombinants were obtained. Analyses gene composition showed that all had inherited their haemagglutinin from parent strain. majority received other segments was shown to inhibit red blood cell lysis induced either by purified virions or FPV at low pH, but failed...
SUMMARY A fowl plague virus (FPV) temperature-sensitive mutant, ts 303/1 having a mutation in gene 7 coding for the matrix (M) protein has been obtained. The mutant induced synthesis of virus-specific RNA and polypeptides as well ribonuclear (RNP) formation cells under non-permissive conditions; however, haemagglutinin cleavage was reduced, functionally active neuraminidase were absent virions not formed. In mutant-infected at 36 °C also reduced formed had an altered NP:M ratio decreased...
Purpose: characterization of vFiraVax (the causative agent chickenpox - VZV) and vZelVax shingles HZ) vaccine strains by their ability to bind preparations brain membrane receptors SPF BALB/c mice.Materials Methods. The study was performed on cold-adapted VZV HZ developed the authors basis wild-type parental pFira virus (chickenpox agent) latent lpZel (shingles agent); vOka isolated from vaccines against infection two manufactures (United Kingdom USA); HEL-3 strain diploid cells human...