A5006771750- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Gut microbiota and health
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Metabolism and Genetic Disorders
- Gastrointestinal motility and disorders
- Thermal Regulation in Medicine
- Neurological disorders and treatments
- Infectious Encephalopathies and Encephalitis
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Genomics and Rare Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacological Effects and Toxicity Studies
- Ion Channels and Receptors
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Sleep and Wakefulness Research
- Neurological and metabolic disorders
University of Calgary
2014-2024
Alberta Children's Hospital
2014-2024
Alberta Children's Hospital Research Institute
2014-2024
Allen Institute for Brain Science
2024
Pediatrics and Genetics
2024
Montefiore Medical Center
2007-2011
Albert Einstein College of Medicine
2007-2011
Université de Montréal
2004-2008
The infantile spasms syndrome is an early-onset epileptic encephalopathy presenting in the first 2 years of life, often with severe developmental consequences. role gut microbiota and metabolism remains unexplored.Employing a brain injury neonatal rat model intractable to anticonvulsant medication treatments, we determined how ketogenic diet antibiotics affected specific microbial communities resultant circulating factors that confer protection model. To confirm kynurenine pathway...
The atypical febrile seizure has important clinical implications because of its association with the mesial temporal lobe epilepsy syndrome, which is most common intractable epilepsies. However, whether a causal relation exists between these conditions currently unknown. We have previously shown that focal cortical lesion induced in neonatal rat predisposes to development hyperthermic seizures. show here 86% plus hyperthermia group experience spontaneous recurrent seizures recorded from...
Infantile spasms syndrome (IS) is a type of epilepsy affecting 1.6 to 4.5 per 10,000 children in the first year life, often with severe lifelong neurodevelopmental consequences. Only two first-line pharmacological treatments currently exist for IS and many are refractory these therapies. In such cases, treated ketogenic diet (KD). While effective reducing seizures, can result dyslipidemia over time.Employing neonatal Sprague-Dawley rat model IS, we investigated how KD affects hepatic...
Abstract Objective KCTD7 ‐related progressive myoclonic epilepsy (PME) is a rare autosomal‐recessive disorder. This study aimed to describe the clinical details and genetic variants in large international cohort. Methods Families with molecularly confirmed diagnoses of PME were identified through collaboration. Furthermore, systematic review was done identify previously reported cases. Salient demographic, epilepsy, treatment, testing, electroencephalographic (EEG), imaging‐related variables...
Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic diet (KD) often employed to control seizures. Since therapeutic impact of KD influenced by gut microbiota, we examined whether targeted microbiota manipulation, mimicking changes induced KD, would be valuable in mitigating Employing rodent...
Abstract We have shown previously that the ketogenic diet (KD) is effective in reducing seizures associated with infantile spasms syndrome (ISS) and this benefit related to alterations gut microbiota. However, it remains unclear whether efficacy of KD persists after switching a normal diet. Employing neonatal rat model ISS, we tested hypothesis impact would diminish when switched Following epilepsy induction, rats were divided into two groups: continuous for 6 days; group fed 3 days then...
To determine the effects of focal cortical dysplasia on behavioral and electrographic features hyperthermia-induced seizures (HSs) in rats.A right sensorimotor cortex freeze lesion was induced postnatal day 1 (P1) rat pups, HSs were provoked at P10 under continuous monitoring core temperature; EEGs recorded from amygdala during after hyperthermia. Controls included both sham-operated P1 naïve rats.HSs began with jaw myoclonus, followed by hindlimb clonus generalized convulsions (GCs),...
Extreme heat caused by climate change is increasing the transmission of infectious diseases, resulting in a sharp rise heat-related illness and mortality. Understanding mechanistic link between heat, inflammation, disease thus important for public health. Thermal hyperpnea, consequent respiratory alkalosis, crucial febrile seizures convulsions induced stress humans. Here, we address what causes thermal hyperpnea neonates how it affected inflammation. Transient receptor potential cation...
Summary: Status epilepticus (SE) is a significant neurological emergency that occurs most commonly in children. Although SE has been associated with an elevated risk of brain injury, it unclear from clinical studies whom and under what circumstances injury will occur. The purpose this review to evaluate the effects age on consequences SE. In review, we focus mainly animal data describe single episode induced adult immature rat brain. experimental suggest developing SE‐induced damage,...
Type 3 Gaucher disease (GD3) is characterized by progressive neurological features in addition to the typical systemic manifestations. Enzyme replacement therapy (ERT), main stay treatment for (GD), not efficacious Ambroxol, combination with ERT has been suggested have potential as a promising patients GD3. The purpose of this study assess effect Ambroxol on glucosylsphingosine (Lyso-Gb1) levels, and morbidity, two Canadian
Abstract Objective Brain tissue oxygen (partial pressure [pO 2 ]) levels are tightly regulated to stay within the normoxic zone, with deviations on either side resulting in impaired brain function. Whereas pathological events such as ischemic attacks and brief seizures have previously been shown result pO well below during prolonged status epilepticus (SE) subsequent endogenous kindling period unknown. Methods We utilized two models of acquired temporal lobe epilepsy rats: intrahippocampal...
Objectives: The use of telemedicine has grown exponentially as an alternative to providing care patients with epilepsy during the pandemic. We investigated impact current pandemic among children from two distinct pediatric centers. also compared perceptions those who received against did not. Methods: developed a questionnaire and invited families followed in Freiburg, Germany, Calgary, Alberta, Canada, participate initial 9 months survey contained 32 questions, 10 which were stratified...
Patients with epileptic encephalopathy spike wave activation in sleep (EE-SWAS) often display drug-resistant epilepsy. The of activity during is associated temporally neurocognitive impairment and causes a spectrum disorders within the epilepsy-aphasia syndrome. prognosis dependent on promptness treatment etiology. However, there no clear consensus regards to optimal management for patients EE-SWAS. We queried our Pediatric Epilepsy Outcome-Informatics Project (PEOIP) database all treated...