A5050465459- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Prenatal Substance Exposure Effects
- Opioid Use Disorder Treatment
- Total Knee Arthroplasty Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Sepsis Diagnosis and Treatment
- Sports Performance and Training
- Shoulder Injury and Treatment
- Cardiac Arrest and Resuscitation
- Birth, Development, and Health
- Periodontal Regeneration and Treatments
- Eating Disorders and Behaviors
- Hip and Femur Fractures
- Dental Radiography and Imaging
- Vitamin C and Antioxidants Research
- Social Media in Health Education
- Intensive Care Unit Cognitive Disorders
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury Research
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthodontics and Dentofacial Orthopedics
- Cardiac, Anesthesia and Surgical Outcomes
- Mobile Health and mHealth Applications
University of Kentucky
2019-2025
Brigham and Women's Hospital
2023
Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development new functional limitations that persist for years. To delineate mechanisms sepsis-induced weakness, we first surpassed barrier by establishing murine model with ICU-like interventions allows the study survivors. We show have profound at least 1 month, even after recovery mass. Abnormal mitochondrial ultrastructure, impaired...
Elevated plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are documented in patients with sepsis and positively correlate disease severity mortality. Our prior work demonstrated that PAI-1 is associated acute kidney injury (AKI) septic mice. The objective this study was to determine if causally related AKI worse outcomes using a clinically-relevant age-appropriate murine model sepsis. Sepsis induced by cecal slurry (CS)-injection wild-type (WT, C57BL/6) knockout (KO) mice at...
Abstract Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) often performed to extend a patient’s eligibility LT. Imaging has modest sensitivity of approximately 40–77% detecting pathologically viable HCC post-LRT The impact on overall survival (OS) and disease-free (DFS) unclear. We hypothesize that Reporting & Data Systems Treatment Response (LI-RADS TR) category equivalently...
To evaluate the content and quality of YouTube videos concerning patellar dislocations."Patellar dislocation" "kneecap were searched on library. The Uniform Resource Locator first 25 suggested was extracted, for a total 50 videos. following variables collected each video: number views, duration in minutes, video source/uploader, type, days since upload, view ratio (views/day), likes. Video source/uploader categorized as academic, physician, nonphysician, medical source, patient, commercial,...
The anterior cruciate ligament (ACL) is commonly injured in elite-level female athletes, which usually requires ACL reconstruction (ACLR).To analyze return to play (RTP) and changes performance of players the National Women's Soccer League (NWSL) after ACLR.Descriptive epidemiology study.NWSL who sustained an tear underwent surgery between 2013 2020 seasons were identified by multiple online resources. Players classified as forwards, defenders, midfielders, goalkeepers. RTP was assessed...
Musculoskeletal disorders contribute substantially to worldwide disability. Anterior cruciate ligament (ACL) tears result in unresolved muscle weakness and posttraumatic osteoarthritis (PTOA). Growth differentiation factor 8 (GDF8) has been implicated the pathogenesis of musculoskeletal degeneration following ACL injury. We investigated GDF8 levels ACL-injured human skeletal serum tested a humanized monoclonal antibody against placebo mouse model PTOA (surgically induced tear). In patients,...
γδ T cells are resident in visceral adipose tissue (VAT) where they show an age-associated increase numbers and contribute to local systemic chronic inflammation. However, regulation of this population mechanisms for the age-dependent accumulation not known. In study, we identified a progressive trend cell VAT over lifespan mice explored physiological contributing accumulation. Using isochronic parabiotic pairs wild-type (WT) receptor delta knockout (TCRδ KO) at young old age, confirmed that...
Abstract Graham, MC, Thompson, KL, Hawk, GS, Fry, CS, and Noehren, B. Muscle fiber cross-sectional area is associated with quadriceps strength rate of torque development after ACL injury. J Strength Cond Res 38(6): e273–e279, 2024—The purpose this study was to investigate the relationship between muscle type–specific properties vastus lateralis performance in individuals an anterior cruciate ligament (ACL) tear. 26 subjects (22.0 ± 5.4 years) were included study, all data collected before...
Purpose: Preoperative mood disorders influence postoperative outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR), but the prevalence and risk factors associated with depression/anxiety development remain unknown. The purposes of this study were to quantify diagnoses depression or anxiety following ACLR in patients under age 25 assess interplay between patient sex ACL reoperation on a diagnosis ACLR. Methods: years old identified Truven Healthcare Marketscan database....
Introduction Affecting more than 30 million adults annually, osteoarthritis (OA) is the most common joint disorder in United States. A variety of management options for knee OA exists, including physical therapy, weight loss, intra-articular corticosteroid injections, and total arthroplasty. With many treatments available, patients often utilize internet to educate themselves about their condition options. The purpose this study was evaluate quality, transparency, readability online...
Complete denture fabrication requires multiple clinical and laboratory steps. One of the most critical steps is establishing an anatomical occlusal plane based on hard soft tissue references. The aim this study was to determine whether age or gender affects level Ala-Tragus establish which reference point Tragus should be used when fabricating in edentulous patients. Clinical photographs lateral cephalometric radiographs with complete dentitions were taken from 58 volunteers at DMD clinic...
There is a lack of vapor intrusion (VI) models that reliably account for weather conditions and building characteristics, especially at sites where active alternative pathways, such as sewer connections other preferential are present.
OBJECTIVES: To determine whether scheduled low-dose, short-term ketorolac modulates cytokine concentrations in orthopaedic polytrauma patients. METHODS: Design: Secondary analysis of a double-blinded, randomized controlled trial. Setting: Single Level I trauma center from August 2018 to October 2022. Patient Selection Criteria: Orthopaedic patients between 18-75 years with New Injury Severity Score greater than 9 were enrolled. Participants receive 15 mg intravenous (IV) every 6 hours for up...
OBJECTIVES: To compare radiographic and clinical outcomes in non-operative management of humeral shaft fractures treated initially with coaptation splinting (CS) followed by delayed functional bracing (FB) versus treatment immediate FB. METHODS: Design : Retrospective cohort study Setting: Academic Level 1 Trauma Center Patient Selection Criteria: Patients closed managed non-operatively initial CS FB or from 2016 to 2022. younger than 18 years and/or less 3 months follow-up were excluded....
Evaluate maternal and neonatal outcomes after buprenorphine wean compared to patients maintained on throughout pregnancy.
A Lisfranc injury can occur to either the ligament or bone, which causes instability when attempting perform strength and balance maneuvers.The study's aims were (1) analyze return-to-play (RTP) rate performance level of players in National Football League (NFL) after (2) determine economic financial impact injuries NFL. We hypothesized that there would be a low RTP following NFL.Case series; Level evidence, 4.Multiple online public records used identify NFL with between 2009 2020 seasons....
This study compared perceived social support among women of all body mass index (BMI) categories with an attempt to assess the efficacy BumptUp® mobile application improve for exercise during pregnancy and postpartum. Thirty-five pregnant living in Southern United States were included sample. The intervention group received access that was designed promote physical activity control evidence-based educational brochure. Perceived assessed at four-time points using survey. Outcomes evaluated...
In this study, we investigated whether patients undergoing arthroscopic treatment of femoral acetabular impingement syndrome (FAIS) seek health care for comorbid depression and anxiety in the year following hip arthroscopy.Using Truven Health Marketscan database, FAIS who underwent arthroscopy between January 2009 December 2016 were identified. Claims related to or filed during before surgery required inclusion. Using claims pharmaceutical psychological therapy treatments mental disorders,...
To combat maternal morbidity and mortality, interventions designed to increase physical activity levels during after pregnancy are needed. Mobile phone-based show considerable promise, BumptUp® has been carefully developed address the lack of exercise among pregnant postpartum women. The primary goal this pilot study was test potential efficacy for improving A randomized controlled clinical trial performed (N = 35) with women either receiving access mhealth app or an educational brochure....