A5017017668- Berberine and alkaloids research
- Botanical Research and Chemistry
- Synthesis and bioactivity of alkaloids
- Biochemical and Structural Characterization
- Plant biochemistry and biosynthesis
- Plant tissue culture and regeneration
- Toxin Mechanisms and Immunotoxins
- Pregnancy and preeclampsia studies
- Plant Genetic and Mutation Studies
- Birth, Development, and Health
- Plant-Microbe Interactions and Immunity
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Species Distribution and Climate Change
- T-cell and Retrovirus Studies
- Reproductive Biology and Fertility
- Insect Pest Control Strategies
- Plant-based Medicinal Research
- Insect Resistance and Genetics
- Essential Oils and Antimicrobial Activity
- Genomics and Phylogenetic Studies
- Antimicrobial Peptides and Activities
- Transgenic Plants and Applications
- Plant Pathogenic Bacteria Studies
- Bacterial Identification and Susceptibility Testing
Adam Mickiewicz University in Poznań
2014-2024
Medical University of Lublin
2024
Red Deer Regional Hospital
1988
A comparative analysis of the placental microbiome in pregnancies with late fetal growth restriction (FGR) was performed normal to assess impact bacteria on development and function. The presence microorganisms placenta, amniotic fluid, membranes umbilical cord blood throughout pregnancy disproves theory "sterile uterus". FGR occurs when fetus is unable follow a biophysically determined path. Bacterial infections have been linked maternal overproduction pro-inflammatory cytokines, as well...
A novel annotated Chelidonium majus L. transcriptome database composed of 23,004 unique coding sequences allowed to significantly improve the sensitivity proteomic C. assessments, which showed defense-related proteins characteristic its latex. To date, composition milky sap and biosynthesis components are poorly characterized. We, therefore, performed de novo sequencing assembly using Illumina technology. Approximately, 119 Mb raw sequence data was obtained. Assembly resulted in 107,088...
Yellow-orange latex of Chelidonium majus L. has been used in folk medicine as a therapeutic agent against warts and other visible symptoms human papillomavirus (HPV) infections for centuries. The observed antiviral antitumor properties C. are often attributed to alkaloids contained therein, but recent studies indicate that proteins may also play an important role its pharmacological activities. Therefore, the aim study was investigate effect crude protein alkaloid-rich fractions on different...
Milky sap isolated from Chelidonium majus L. (Greater Celandine) serves as a rich source of various biologically active substances such alkaloids, flavonoids and phenolic acids. Previous research showed that the activity Ch. milky may depend also on presence proteins. The goal this study was to evaluate biological effect two nucleases milk sap, CMN1 20 kDa CMN2 36 kDa, HeLa CHO tumour cell lines. Both studied together with other proteins in plant are involved stress defence reactions against...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of unknown pathology, involving reproductive and metabolic abnormalities. Oocyte-specific genes are group expressed exclusively in ovarian tissue; therefore, they can play an important role pathologies such as PCOS. The zona pellucida 4 (ZP4) gene encodes glycoprotein which part the extracellular matrix oocyte.We analyzed 87 patients with PCOS, were divided into four groups depending on their phenotype. In each patient, we...
Fetal growth restriction (FGR) occurs when the fetus does not reach its genetically programmed intrauterine potential for and affects ~5‑10% of pregnancies. This condition is one leading causes perinatal mortality morbidity associated with obstetric neonatal complications. Placental dysfunction in FGR an impairment transfer nutrients oxygen from mother to developing fetus. Maternal adaptations placental insufficiency may also play a role pathophysiology FGR. The present study aimed compare...
Abstract Tardigrada (water bears) are a group of small invertebrates known for their ability to survive extreme desiccation by entering an anhydrobiotic state. This state is characterized the loss ≤ 98% body water, resulting in shrinkage and almost complete cessation metabolism. In anhydrobiosis, multiple mechanical biochemical stress effects, such as protein denaturation aggregation, DNA damage, formation reactive oxygen species, membrane disintegration degeneration cellular compartments,...
Corydalis cava Schweigg. & Koerte, the plant of numerous pharmacological activities, together with studied earlier by our group Chelidonium majus L. (Greater Celandine), belong to family Papaveraceae. The grows in Central and South Europe produces sizeable subterraneous tubers, empty inside, which are extremely resistant various pathogen attacks. sp. tubers a rich source many biologically active substances, extensive use European Asian folk medicine. They have analgetic, sedating, narcotic,...
The family of glycine-rich plant proteins (GRPs) is a large and complex group that share, as common feature, the presence domains arranged in (Gly)n-X repeats are suggested to be involved protein-protein interactions, RNA binding, nucleolar targeting. These implicated several independent physiological processes. Some components cell walls many higher plants, while others molecular responses environmental stress, mediated by post-transcriptional regulatory mechanisms. goals this study...
Chelidonium majus, known as Greater Celandine, is a latex-bearing plant that has been leveraged for its anticancer and antimicrobial properties. Herein, C. majus aerial tissue mined the presence of peptides. A highly abundant cysteine-rich peptide with length 25 amino acids, deemed CM-AMP1, characterized through multiple mass spectrometric approaches. Electron-activated dissociation to differentiate between isoleucine leucine residues complement conventional collision-induced gain full...