A5033146351- Virus-based gene therapy research
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
University of Amsterdam
2019
Amsterdam University Medical Centers
2019
Institut Català d'Oncologia
2011-2013
Institut d'Investigació Biomédica de Bellvitge
2011-2013
Abstract Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on consensus sequence all group M isolates (ConM). The ConM displays epitopes most known bNAbs and several germline bNAb precursors. crystal structure 3.9 Å resolution resembles its surface few residues....
Replication-competent adenoviruses armed with thymidine kinase (TK) combine the concepts of virotherapy and suicide gene therapy. Moreover TK-activity can be detected by noninvasive positron emission-computed tomography (PET) imaging, what could potentially facilitate virus monitoring in vivo. Here, we report generation a novel oncolytic adenovirus that incorporates Tat8-TK under control Major Late Promoter highly selective backbone thus providing selectivity targeting retinoblastoma...
Gene-based anticancer therapies delivered by adenoviruses are limited the poor viral distribution into tumor. In current work we have explored feasibility of targeting pancreatic tumors through a loco-regional route. We taken advantage ductal network in pancreas to retrogradelly inject common bile duct two different mouse models carcinogenesis: The transgenic Ela-myc mice that develop mixed neoplasms displaying both acinar-like and duct-like neoplastic cells affecting whole pancreas; bearing...