A5005077610- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Radioactive element chemistry and processing
- Click Chemistry and Applications
- Extraction and Separation Processes
- Chemokine receptors and signaling
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Crystallography and molecular interactions
- Ionic liquids properties and applications
- Sarcoma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Crystallization and Solubility Studies
- Aluminum toxicity and tolerance in plants and animals
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Cell death mechanisms and regulation
- Chemical Synthesis and Analysis
- Optical Imaging and Spectroscopy Techniques
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- X-ray Diffraction in Crystallography
- Cardiac tumors and thrombi
Iran University of Medical Sciences
2018-2024
Shaheed Rajaei Cardiovascular Medical and Research Center
2020
Murdoch University
2018
Tehran University of Medical Sciences
2012
University of Zanjan
2003
Alzheimer's disease (AD) is a constant, developing brain impairment that described as the aggregation of misfolded amyloid-beta-peptide (Ab) and abnormal tau protein in brain. Stem cell therapy became favorable candidate for regeneration neurodegenerative disorders like AD, but there still shortage knowledge about underlying mechanisms. The goal this survey was determination necroptotic pathway possible mechanism effect human adipose-derived stem cells (hADSCs) rat model AD.Twelve rats were...
In spite of previous efforts, there is lack a radiotracer for imaging the 5HT1A receptor density in human brain, which involved several neurological brain disorders. The aim this study was to prepare new derivative 1-(2-methoxyphenyl)piperazine (MPP) as main chemical structure antagonist with 3-carbon linker and radiolabeled by [99m Tc][Tc(CO)3 (H2 O)3 ]+ precursor. Docking studies before synthesis showed similar fashion interaction both WAY100635 (potent antagonist) designed ligand, despite...
To develop a novel 5HT 1A receptor imaging agent, new methoxyphenyl piperazine derivative was synthesized and radiolabeled with 99m Tc‐tricarbonyl precursor. We used the Cu (I)‐catalyzed cycloaddition of azide terminal alkynes to synthesize 1, 2, 3 triazole as metal chelating system. This synthesis provided reliable reproducible method attach technetium moiety. Tc‐tricabonyl labeling ligand performed at high radiochemical purity (greater than 95%). The compound stable least 24 h in room...
Phosphoryl containing ligand tri-n-octylphosphine oxide (TOPO) in dichloromethane has been used as an extracting agent for tetravalent thorium and trivalent europium ions from their 1 M sodium nitrates. The equilibrium data reveal that both are extracted the complexes at 1:3 metal/ligand ratio. values of conditional extraction constant (Kex) show superior extractive properties towards than ions. effects solvent, type concentration the salting-out on abilities investigated. influence...
The technetium-99m ethylene dicysteine (Tc-99m EC) is a radiopharmaceutical used for renal scintigraphy, noninvasive imaging technique that assesses kidney function as well urinary tract obstruction. We describe the extrarenal Tc-99m EC uptake in 70-year-old man with recurrent well-differentiated abdominal liposarcoma. In present case, both liposarcoma lesions which were diagnosed by CT scan showed heterogeneous accumulation of EC.
Introduction: C-X-C Chemokine receptor type 4 (CXCR4) is often overexpressed or overactivated in different types and stages of cancer disease. Therefore, it considered a promising target for imaging early detection primary tumors metastasis. In the present research, new cyclo-peptide radiolabelled with 99mTc, 99mTc-Cyclo [D-Phe-D-Tyr-Lys (HYNIC)- D-Arg-2-Nal-Gly-Lys(iPr)], was designed based on parental LY251029 peptide, as potential vivo agent CXCR4-expressing tumors. Methods: The...
Chemokine receptor (CXCR-4) is overexpressed in many types of tumors and promotes cancer metastasis. The expression level CXCR4 the sign metastatic potential tumor determines organ-specific This chemokine considered a promising target for treatment molecular imaging. In this study, cyclo-peptide as antagonist was successfully synthesized applying standard Fmoc solid-phase strategy radio-labeled with Sodium Pertechnetate via HYNIC chelator EDDA/tricine co-ligands. ligand manually high yield...