A5085624556- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Synthesis and biological activity
- Antifungal resistance and susceptibility
- Orthopedic Infections and Treatments
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- HER2/EGFR in Cancer Research
- Synthesis and Biological Evaluation
- Antimicrobial Peptides and Activities
- Monoclonal and Polyclonal Antibodies Research
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Neuroendocrine Tumor Research Advances
- Fungal Infections and Studies
- Bone health and treatments
- Pancreatitis Pathology and Treatment
- Ophthalmology and Eye Disorders
- Veterinary medicine and infectious diseases
- Cancer Research and Treatments
- Poisoning and overdose treatments
- Lung Cancer Research Studies
- Marine Toxins and Detection Methods
- Bacillus and Francisella bacterial research
Birjand University of Medical Sciences
2021-2023
Tehran University of Medical Sciences
2020-2022
Imam Khomeini Hospital
2022
Baqiyatallah University of Medical Sciences
2021
Nuclear Science and Technology Research Institute
2012-2018
Atomic Energy Organization of Iran
2007-2018
Demand has arisen for developing new azole antifungal agents with the growth of resistant rate infective fungal species to current antifungals in recent years. Accordingly, present study reports synthesis novel fluconazole (FLC) analogues bearing urea functionality that led discovering promising activities. In particular, compounds
A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), acetyl- butyrylcholinesterase (AChE BuChE) find most potent derivative Alzheimer's disease (AD). Most compounds showed weak moderate activity ChEs. Among active BuChE 15-LOX inhibitors, 8l 8n exhibited an excellent neuroprotective effect, higher than standard drug (quercetin) on PC12 cell model injured by H2O2 significantly reduced aggregation amyloid...
Even in recent decades, one of the major causes death and unhealthiness whole world is infection inflammation. The use radiopharmaceuticals a powerful tool managing patients with infectious diseases. In this study, ofloxacin as second‐generation fluoroquinolone has been labeled [ 99m Tc(CO) 3 (H 2 O) ] + core to formulate suitable imaging agent. Ofloxacin was radiolabeled Tc using carbonyl core. Radioligand chemical analysis involved HPLC methods. Radioconjugate stability lipophilicity were...
In this study, a new neurotensin (NT) analog was labeled with (99m) Tc via HYNIC chelator and tricine as coligand investigated further. An NT (7-13) prepared, labeling performed. The internalization rate biodistribution of radiopeptide were studied in HT-29 cells nude mice bearing tumor, respectively. Radiolabeling performed at high specific activities (54 MBq/nmol) an acceptable yield (>95%). vitro cell line studies showed uptake up to 13.23 ± 0.45% during 4 h which blocked the presence...
Due to high expression of CXCR4 (CXC chemokine receptor type 4) receptors in many tumors and metastasis, synthesis labeling receptor-targeted analogs as tumor imaging agents have been encouraged. Herein, peptide antagonist was prepared thereafter its with 99mTc by a bifunctional chelating agent tricine coligand developed. Radiotracer purity, stability, cell binding were assessed. Bioevaluation radiotracer performed mice bearing xenograft tumor. More than 95% yield stability up 24 hours...
Somatostatin-derived analogues play an important role in the diagnosis and treatment of neuroendocrine tumors. The aim this study was to evaluate a new somatostatin analogue designed for labeling with (99m)Tc: [6-hydrazinopyridine-3-carboxylic acid (HYNIC(0)), β-(3-benzothienyl)-Ala (BzThi(3))]-octreotide ([HYNIC]-BOC), using ethylenediamine-N,N'-diacetic (EDDA) tricine as coligands. Synthesis performed on solid phase standard Fmoc strategy. HYNIC-peptide conjugate radiolabeled (99m)Tc...
Quinoline-based structures possess various types of biological activities and recently have attracted attention as an antitumor scaffold via different known anti-cancer mechanisms. In this study, a novel series tetrahydropyrimido[4,5-b]quinoline-4,6(3H,7H)-diones (7a-r) were synthesized evaluated for their in vitro cytotoxic effects on breast cancer cells (MCF-7 cells), prostate (LNCaP normal human adult dermal fibroblast (HDF) cells. Among them, the compounds (7c), (7d), (7 g), (7j), (7k),...
Alzheimer's disease (AD), is among the most growing neurodegenerative diseases, which mainly caused by acetylcholine neurotransmitter loss in hippocampus and cortex. Emerging of dual Acetylcholinesterase (AChE)/Butyrylcholinesterase (BuChE) inhibitors has increased for treating Alzheimer disease. In this study, we would like to report design synthesis a new sequence 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) assessed as BuChE AChE inhibitors. Ellman's...
Imaging of inflammation has an important role in dissolving problems diagnosis and therapy patients with inflammatory disorders. In this study meloxican as a nonsteroidal anti-inflammatory drug (NSAID) been labeled thechnetium-99m-tricarbonyl core ([(99m) Tc (CO)3 (H2 O)3 ](+) ) order to evaluate its feasibility imaging agent for vivo use. (99m) Tc-tricabonyl labeling meloxicam was performed by incubation prepared precursor heating boiling water bath 30 min while various range pH (1-9)...
Purpose: To investigate the correlation between vestibular hydrops (VH), cochlearhydrops (CH), aqueduct non-visibility (VANV), and visually increased perilymphatic enhancement (VIPE) with findings of pure-tone audiometry (PTA) in Meniere's disease (MD) patients. Methods: In this cross-sectional study, 53 ears belonging to 48 patients were divided into two groups evaluated. group "MD patients," there 24 19 diagnosed definite MD (14 unilateral 5 withbilateral involvements). The "control group"...
In the present study paclitaxel (taxol) was labeled with [99m Tc(CO)3 (H2 O)3 ]+ core. Labeling optimized, and radiochemical analysis determined by thin layer chromatography high performance liquid chromatography. Radiocomplex evaluated verified further as a tumor characterization agent in B16-F10 melanoma tumor-bearing mice. The -paclitaxel complex specific activity (0.77 GBq/μmol) labeling yield (96.8 ± 1.3) obtained. No decrease observed up to 6 hours, stability of radiocomplex found...