A5101596356- Neurogenesis and neuroplasticity mechanisms
- Vascular Anomalies and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Nerve injury and regeneration
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Vagus Nerve Stimulation Research
- Algal biology and biofuel production
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Vascular Malformations and Hemangiomas
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Healthcare and Venom Research
- Human Health and Disease
- Biofield Effects and Biophysics
- Menstrual Health and Disorders
- Neuroscience and Neuropharmacology Research
- Radiation Dose and Imaging
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
University of California, San Francisco
2022-2025
Namazi Hospital
2025
Shiraz University of Medical Sciences
2021-2025
Tabriz University of Medical Sciences
2020-2023
Ahvaz Jundishapur University of Medical Sciences
2022
Islamic Azad University of Tabriz
2021
Islamic Azad University of Gachsaran
2020
Shahid Sadoughi University of Medical Sciences and Health Services
2019
Amirkabir University of Technology
2016-2019
University of Isfahan
2016
Hereditary Hemorrhagic Telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare and inherited vascular disorder characterized by the development of arteriovenous malformations (AVMs) in various organs telangiectasia (small AVM) mucocutaneous. The majority HHT patients have haploinsufficiency genes involved transforming growth factor-beta (TGF-β) signaling pathway, including endoglin (ENG), activin receptor-like kinase 1 (ALK1, ACVRL1), or SMAD4. Active angiogenesis required...
Ischemic stroke is characterized by extensive neuronal loss, glial scar formation, neural tissue degeneration that leading to profound changes in the extracellular matrix, circuitry, and long-lasting functional disabilities. Although transplanted stem cells (NSCs) can recover some of deficit after stroke, retrieval not complete repair lost negligible. Therefore, current challenge use combination NSCs with suitably enriched biomaterials retain these within infarct cavity accelerate formation...
As the name implies, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus and member of corona family, primarily affecting upper system lungs. Like many other viruses, SARS-CoV-2 can spread to organ systems. Apart from causing diarrhea, another most common but debilitating complication caused by neurological symptoms cognitive difficulties, which occur in up two thirds hospitalized covid patients ranging shortness concentration, overall declined speed...
Background: The increase in the collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow pressure changes. Activated microglia enhance inflammation-induced fibrosis. Hypotheses: COL I/COL human mouse brain arteriovenous malformations (bAVMs) is associated with bAVM hemorrhage, depletion of decreases hemorrhage. Method: I, III, hemorrhages were analyzed 12 bAVMs 6 control brains, induced three lines activin receptor-like kinase 1 (n = 7)...
Abstract: Hypertension, a condition characterized by elevated blood pressure, poses significant medical risk, particularly in relation to the development of cardiovascular disease. The pathogenesis hypertension can be influenced combination genetic and environmental factors. Recent scientific studies have shed light on involvement long-non-coding RNAs (lncRNAs) various diseases, including pulmonary arterial essential hypertension. These lncRNAs been found play crucial roles at...
Hereditary Hemorrhagic Telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare and inherited vascular disorder, characterized by the development of arteriovenous malformations (AVMs) in various organs telangiectasia (small AVM) mucocutaneous. The majority HHT patients have haploinsufficiency genes involved transforming growth factor-beta (TGFβ) signaling pathway, including endoglin (ENG), activin receptor-like kinase 1 (ALK1, ACVRL1), or SMAD4. Active angiogenesis required...
Introduction: It is generally accepted that cutaneous leishmaniasis considered as an important health problem all over the world which caused by protozoan. This disease also known a in some regions of Iran including Bushehr province. The present study investigated geographical dispersion and epidemiological characteristics subjects with this province from 2011 to 2015. Method: In cross-sectional analytical study, epidemiologic data age, gender, residential area, counties was analyzed...
In the present study paclitaxel (taxol) was labeled with [99m Tc(CO)3 (H2 O)3 ]+ core. Labeling optimized, and radiochemical analysis determined by thin layer chromatography high performance liquid chromatography. Radiocomplex evaluated verified further as a tumor characterization agent in B16-F10 melanoma tumor-bearing mice. The -paclitaxel complex specific activity (0.77 GBq/μmol) labeling yield (96.8 ± 1.3) obtained. No decrease observed up to 6 hours, stability of radiocomplex found...
<title>Abstract</title> Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with hereditary hemorrhagic telangiectasis (HHT). All available managements have limitations. We showed that intravenous delivery soluble FMS-related tyrosine kinase 1 using an adeno-associated viral vector (AAV9-sFLT1) reduced bAVM severity <italic>endoglin</italic> deficient mice. However, minor liver inflammation growth arrest in...
Endoglin (ENG) mutation causes type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have arteriovenous malformations (AVMs) in multiple organs, including the brain. In mice, Eng deletion induced by R26RCreER or SM22αCre leads to AVM development brain and other organs. We hypothesized that an increase Eng- negative ECs will enhance severity. To EC deletion, we used a codon-improved cre (icre), which is more potent recombination of floxed alleles than wild-type (WT) cre....
Background: Increase of collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow pressure changes. We hypothesized that COL I/COL is increased in the brain arteriovenous malformations (bAVMs), which associated with bAVM hemorrhage. Method: Surgically resected human samples mouse bAVMs induced three transgenic lines activin receptor-like kinase 1 or endoglin deletion endothelial cells focally. Colony-stimulating factor receptor inhibitor...
Electromagnetic fields (EMFs) could induce oxidative stress (OS) in human tissues. Lipid peroxidation (LPO) is the main hallmark of OS that harms neural cell components, primarily lipids myelin sheaths and membranes. Vitamin E a lipophilic antioxidant protects cells from OS-related damages inhibits LPO process. In this study, male rats were assigned into three groups Control, EMF, EMF+ E. The EMF producer equipment produced an alternate current 50 Hz, 3 Mili Tesla (mT). At end experiment,...