A5047122641- Growth Hormone and Insulin-like Growth Factors
- Kruppel-like factors research
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Hypothalamic control of reproductive hormones
- Genetic Syndromes and Imprinting
- Spinal Dysraphism and Malformations
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Pregnancy-related medical research
- Reproductive System and Pregnancy
- Regulation of Appetite and Obesity
- Birth, Development, and Health
Universidad Nacional Autónoma de México
2017-2024
The Krüppel-like factors (KLFs) have emerged as important transcriptional regulators of various cellular processes, including neural development. Some them been described intrinsic involved in axon regeneration the central nervous system (CNS) vertebrates. Zebrafish are known for their ability to regenerate several tissues adulthood, CNS, a capability lost during vertebrate evolution and absent adult mammals. role that KLFs could play this differential remains unknown. Therefore, study, we...
The potential for novel applications of classical hormones, such as gonadotropin-releasing hormone (GnRH) and growth (GH), to counteract neural harm is based on their demonstrated neurotrophic effects in both vitro vivo experimental models a growing number clinical trials. This study aimed investigate the chronic administration GnRH and/or GH expression several proinflammatory glial activity markers damaged tissues, well sensory recovery, animals submitted thoracic spinal cord injury (SCI)....
Growth hormone (GH) is a pituitary protein that exerts pleiotropic roles in vertebrates. The mechanisms regulating GH synthesis and secretion are finely controlled by hypothalamic neuropeptides other factors. These processes have been considerably studied mammals but still poorly understood groups. To better understand the regulation during vertebrate phylogeny, we compared effects of incubating several peptides on cultures ex-vivo fragments obtained from representative specimens reptiles...
The Krüppel-like factor 13 (KLF13) has emerged as an important transcription involved in essential processes of the central nervous system (CNS). It predominantly functions a transcriptional repressor, impacting activity several signaling pathways with roles CNS, including JAK/STAT pathway, which is canonical mediator growth hormone (GH) signaling. now recognized that GH actions neurotrophic factor. Therefore, we analyzed effects KLF13 on pathway hippocampus-derived cell line HT22. Results...
Thoracic spinal cord injury (SCI) profoundly impairs motor and sensory functions, significantly reducing life quality without currently available effective treatments for neuroprotection or full functional regeneration. This study investigated the neurotrophic synaptic recovery potential of gonadotropin-releasing hormone (GnRH) growth (GH) in ovariectomized rats subjected to thoracic SCI. Employing a multidisciplinary approach, we evaluated effects these hormones upon gene expression...