A5039623361- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Pregnancy-related medical research
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Tendon Structure and Treatment
- Spinal Dysraphism and Malformations
- Urological Disorders and Treatments
- Hypothalamic control of reproductive hormones
- Advanced Proteomics Techniques and Applications
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Multiple Sclerosis Research Studies
- Ovarian function and disorders
- Metabolomics and Mass Spectrometry Studies
- Reproductive System and Pregnancy
- Microbial Metabolic Engineering and Bioproduction
Autonomous University of Aguascalientes
2012-2024
Peripheral nerve injuries, such as sciatic transection (SNT), are associated with significant sensory and motor deficits. Growth hormone (GH) gonadotropin-releasing (GnRH) have been shown to exert neurotrophic effects that can promote regeneration functional reinnervation. However, the combined impact of these hormones on peripheral repair remains poorly understood. This study aimed analyze individual GH GnRH in a rat model SNT, using orchiectomized male rats prevent steroid-mediated...
Gonadotropin-releasing hormone (GnRH) and its synthetic analog leuprolide acetate, a GnRH agonist, have neurotrophic properties. This study was designed to determine whether administration of acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology the amount microglia in lesion epicenter after injury rats. Rats with compression were administered or saline solution for 5 weeks. At 5th week, acetate-treated rats showed activity recovery by 38%, had improvement...
The potential for novel applications of classical hormones, such as gonadotropin-releasing hormone (GnRH) and growth (GH), to counteract neural harm is based on their demonstrated neurotrophic effects in both vitro vivo experimental models a growing number clinical trials. This study aimed investigate the chronic administration GnRH and/or GH expression several proinflammatory glial activity markers damaged tissues, well sensory recovery, animals submitted thoracic spinal cord injury (SCI)....
It has been reported that gonadotropin‑releasing hormone (GnRH), and its analogue leuprolide acetate (LA), have neurotrophic properties; particularly in the regeneration of injured spinal cord animal models case a patient with injury (SCI). The aim this study was to establish whether treatment LA improves sensitivity, motor activity independence patients chronic SCI. Patients were treated once month for six months. They evaluated at beginning end treatment; using sensitivity impairment...
Background: The hippocampus is highly vulnerable to damage in the brain ischemia-reperfusion injury model. Leuprolide acetate has been shown promote neurological recovery after various regions of central nervous system. Objective: objective this study was assess histology and expression neuronal markers, specifically 200 kDa neurofilaments myelin basic protein, rats with treated leuprolide acetate. Methods: were divided into three groups: Sham, saline solution, Coronal slices obtained...
The spinal cord is the major conduct through which sensory and motor signals pass between brain body. Spinal injury (SCI) results in a disruption of these pathways dramatic functional losses. There are different experimental approaches to counteracting effects SCI, such as use neurotrophic factors. It has been demonstrated that GnRH its agonist leuprolide acetate (LA) have properties SCI model animals. Here, we report our findings from patient suffering chronic who had undergone treatment...
ABSTRACT Introduction One of the main causes a neurogenic bladder is spinal cord injury (SCI),(SCI), which induces little or no reflex activity. Because this alteration, there an increased risk developing urinary tract infections and kidney damage. Gonadotropin‐releasing hormone (GnRH) treatment has been shown to improve micturition in rat model SCI. Aim The present study was aimed at determining whether GnRH administration capable reduce damage rats with Methods Ovariectomized female Wistar...
Thoracic spinal cord injury (SCI) profoundly impairs motor and sensory functions, significantly reducing life quality without currently available effective treatments for neuroprotection or full functional regeneration. This study investigated the neurotrophic synaptic recovery potential of gonadotropin-releasing hormone (GnRH) growth (GH) in ovariectomized rats subjected to thoracic SCI. Employing a multidisciplinary approach, we evaluated effects these hormones upon gene expression...
The spinal cord is the major conduct through which sensory and motor signals pass between brain body. Spinal injury (SCI) results in a disruption of these pathways dramatic functional losses. There are different experimental approaches to counteracting effects SCI, such as use neurotrophic factors. It has been demonstrated that GnRH its agonist leuprolide acetate (LA) have properties SCI model animals. Here, we report our findings from patient suffering chronic who had undergone treatment...