A5060304511- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Food Industry and Aquatic Biology
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Birth, Development, and Health
- Renin-Angiotensin System Studies
- Child and Animal Learning Development
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Identity, Memory, and Therapy
- Circadian rhythm and melatonin
- Ion channel regulation and function
University of Washington
2015-2025
Ewha Womans University
2023-2024
Seattle University
2019-2021
Korea University
2015
We report how the brain codes predatory threat information to guide and shape foraging behaviors in rats.
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (~65%) unconditioned (US)...
Dopamine is broadly implicated in reinforcement learning, but how patterns of dopamine activity are generated poorly resolved. Here, we demonstrate that two ion channels, Kv4.3 and BKCa1.1, regulate the pattern neuron firing release on different time scales to influence separate phases reinforced behavior mice. Inactivation VTA neurons increases ex vivo pacemaker excitability associated with increased rate ramping dynamics before lever press a learned instrumental paradigm. Loss enhances...
Animals seeking survival needs must be able to assess different locations of threats in their habitat. However, the neural integration spatial and risk information essential for guiding goal-directed behavior remains poorly understood. Thus, we investigated simultaneous activities fear-responsive basal amygdala (BA) place-responsive dorsal hippocampus (dHPC) neurons as rats left safe nest search food an exposed space encountered a simulated 'predator.' In this realistic situation, BA cells...
Pavlovian fear conditioning research suggests that the interaction between dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in formation of associative memories. However, their roles responding to naturalistic predatory threats, characterized by less explicit cues absence reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings rats during an 'approach food-avoid predator' task,...
Trace fear conditioning is characterized by a stimulus-free trace interval (TI) between the conditioned stimulus (CS) and unconditioned (US), which requires an array of brain structures to support formation storage associative memory.The entorhinal cortex (EC) has been proposed provide essential neural code for resolving temporal discontinuity in conjunction with hippocampus.However, how CS TI are encoded at neuronal level EC not clear.In Exp. 1, we tested effect bilateral pre-training...
Surviving in nature requires that animals be able to assess varying locations of danger their environment. However, the neural integration spatial-risk information remains unknown. We investigated simultaneous activities fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons as rats left nest search for food an open space encountered a looming robot ‘predator.’ In this ecological setting, BA cell spiking increased predatory threat, dHPC place field...
Pavlovian fear conditioning research suggests that the interaction between dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in formation of associative memories. However, their roles responding to naturalistic predatory threats, characterized by less explicit cues absence reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings rats during an ‘approach food-avoid predator’ task,...
A positive mental state has been shown to modulate fear-related emotions associated with the recall of fear memories. These, and other observations suggest presence central brain mechanisms for affective states interact. The neurotransmitter dopamine is important both Reward- processes, but it unclear whether contributes such interactions. Here, we show that precisely timed Reward-induced activation neurons in mice potently modifies memories enhances their extinction. This Reward-based...
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (~65%) unconditioned (US)...
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (∼65%) unconditioned (US)...
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (∼65%) unconditioned (US)...
Pavlovian fear conditioning research suggests that the interaction between dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in formation of associative memories. However, their roles responding to naturalistic predatory threats, characterized by less explicit cues absence reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings rats during an ‘approach food-avoid predator’ task,...
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) positive (reward) affective behaviors. CeA been proposed to encode information in the form of valence (whether stimulus is good or bad) salience (how significant stimulus), but extent which these two types representation occur not known. Here, we used single cell calcium imaging mice during appetitive aversive conditioning found that majority neurons (~65%) unconditioned (US)...