A5029281804- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Tea Polyphenols and Effects
- Genomics, phytochemicals, and oxidative stress
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Enzyme Catalysis and Immobilization
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Histone Deacetylase Inhibitors Research
- Adipokines, Inflammation, and Metabolic Diseases
- Garlic and Onion Studies
- Metabolism, Diabetes, and Cancer
- Antioxidant Activity and Oxidative Stress
- Connexins and lens biology
- Ginger and Zingiberaceae research
- Natural Antidiabetic Agents Studies
- Alcohol Consumption and Health Effects
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and biosynthesis
- Bee Products Chemical Analysis
- Tryptophan and brain disorders
- Phytoestrogen effects and research
- Biochemical effects in animals
Food & Nutrition
2023-2024
Korea Food Research Institute
2014-2023
Seoul National University
2013-2017
Queen's Medical Centre
2017
Seonam University
2017
Government of the Republic of Korea
2017
Korea University of Science and Technology
2016
Advanced Institute of Convergence Technology
2014
Purdue University West Lafayette
2014
University of Connecticut
2008-2014
Scope Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis lipid accumulation in vitro, elucidate the anti‐obesity effect of gingerenone A (GA) diet‐induced (DIO), investigate whether GA affects adipose tissue inflammation (ATI). Methods results Oil red O staining showed had most potent inhibitory 3T3‐L1 cells among ginger components tested at a single concentration (40 μM). Consistent with vitro...
GH has a significant impact on body composition due to distinct anabolic and catabolic effects lean fat mass, respectively. Several studies have assessed in mice expressing transgene. Whereas all report enhanced growth of transgenic as compared with littermate controls, there are inconsistencies terms the relative proportion mass these animals. The purpose this study was characterize accumulation adipose age according gender bovine (b) mouse line. Weight measurements were male female bGH...
Abstract Background Whey protein is a potential source of bioactive peptides. Based on findings from in vitro experiments indicating novel whey derived peptide (NOP-47) increased endothelial nitric oxide synthesis, we tested its effects vascular function humans. Methods A randomized, placebo-controlled, crossover study design was used. Healthy men (n = 10) and women (25 ± 5 y, BMI 24.3 2.3 kg/m 2 ) participated two testing days each preceded by wk supplementation with single dose g/day...
Green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by decreasing hepatic steatosis and nuclear factor kappa B (NFκB) activation. We hypothesized that hypolipidemic anti-inflammatory activities of GTE would protect NASH reducing cyclooxygenase-2 (COX-2), an NFκB-dependent enzyme, prostaglandin E2 (PGE2) in a dietary fat-induced obese model. Male Wistar rats were fed low-fat diet containing no or high-fat (HF) at 0%, 1%, 2% for 8 weeks. Insulin resistance total fatty...
Abstract Dynamic alteration of DNA methylation leads to various human diseases, including nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been reported be associated with NAFLD, its exact underlying mechanism remains unclear. Here, we aimed elucidate this in NAFLD vitro and vivo. We first identified alterations the status Cmip intron 1 region mouse tissues high-fat high-sucrose diet-induced NAFLD. Knockdown methyltransferase ( Dnmt ) significantly...
We examined the potential of tannic acid (TA) as a novel histone acetyltransferase inhibitor (HATi) and demonstrated that TA prevents non-alcoholic fatty liver disease (NAFLD) by inhibiting HAT activity. The anti-HAT activity was using assays. An in vitro NAFLD model generated treating HepG2 cells with oleic palmitic acids. Male C57BL/6J mice were fed control diet (CD) or Western (WD) without supplementation either 1% 3% (w/w) for 12 weeks. Finally, possibility interacting p300 simulated....
Phyllanthus emblica is widely used in Ayurvedic preparations against multiple disorders and contains various bioactive components. This study aimed to determine the preventive effect of P. on obesity by evaluating inhibition adipogenesis related regulatory epigenetic mechanisms during 3T3-L1 differentiation. The ethyl acetate fraction (EFPE) effectively inhibited lipid accumulation triglyceride (TG) production adipocytes. It also histone acetyltransferase (HAT) activity regulated...
In the present study, we aimed to investigate antiobesity effect of CAPE in vivo, and mechanism by which regulates body weight vitro. To confirm mice were fed with a high fat diet (HFD) different concentrations for 5 weeks. significantly reduced gain epididymal mass obese HFD. accordance vivo results, Oil red O staining results showed that suppressed MDI-induced adipogenesis 3T3-L1 preadipocytes. FACS analysis delayed MDI-stimulated cell cycle progression, thereby contributing inhibit...
Abstract Cell metastasis is a major cause of death from cancer and can arise excessive levels oxidative stress. The objective this study was to investigate whether the natural flavonoid quercetin inhibit matrix metalloproteinase (MMP)‐2 ‐9 activities through attenuation reactive oxygen species (ROS) formation, an event expected lead inhibition cell motility. To induce sustained ROS cells were treated with phenazine methosulfate (PMS; 1 μM). Noncytotoxic concentrations inhibited PMS‐induced...
Scope Daidzein is one of the major soy isoflavones. Following ingestion, daidzein readily metabolized in liver and converted into hydroxylated metabolites. One such metabolite 6,7,4′‐trihydroxyisoflavone (6,7,4′‐ THIF ), which has been focus recent studies due to its various health benefits, however, anti‐adipogenic activity not investigated. Our objective was determine effects 6,7,4′‐ on adipogenesis 3 T 3‐ L 1 preadipocytes elucidate mechanisms action involved. Methods results Adipogenesis...
Statins mediate the transactivation of PCSK9, which in turn limits their cholesterol-lowering effects <italic>via</italic> LDL receptor (LDLR) degradation.
Few studies have examined the relationship of protein intake by food source with metabolic syndrome in Korean adults, even though animal has increased. This study association between plant and among middle-aged adults. A total 13,485 subjects aged 30–64 years were selected from 2013–2018 Korea National Health Nutrition Examination Survey. Protein was assessed using 24-h dietary recall data divided into quintiles. Men had a higher percentage energy (7.4%) than (6.9%). highest quintile group...
l-α-Glycerylphosphorylcholine (l-α-GPC) is a biosynthetic precursor for the neurotransmitter acetylcholine in humans, making it useful as cognitive enhancer treating patients with stroke and dementia, including Alzheimer's disease. The aim of this study was to prepare l-α-GPC via Novozym 435 (an immobilized Candida antarctica lipase B)-catalyzed hydrolysis soy phosphatidylcholine or fractionated lecithin, from which triacylglycerols were completely removed, followed by food-grade solvent...