Chronic inflammatory enteropathy (CIE) in dogs, a spontaneous model of human bowel disease (IBD), is associated with high rate cobalamin deficiency. The etiology hypocobalaminemia IBD and canine CIE remains unknown, compromised intestinal uptake resulting from ileal receptor deficiency has been proposed as possible cause. Here, we evaluated the expression subunits, amnionless (AMN) cubilin (CUBN), basolateral efflux transporter multi-drug resistance protein 1 (MRP1) 22 dogs comparison to...

Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases affected hosts. A new genotype feline morbillivirus, tentatively named morbillivirus 2 (FeMV-GT2), was isolated from urine cats with urinary tract diseases. Whole genome sequencing showed about 78% nucleotide homology known morbilliviruses. The virus permanent cell lines and simian origin. To investigate the tropism FeMV-GT2 primary epithelial cells kidney, bladder lung, peripheral blood...

Diagnosis of feline chronic inflammatory enteropathies (CIE) and the differentiation from small cell intestinal lymphoma (SCL) can be challenging. Intestinally expressed calprotectin (S100A8/A9 protein complex) appears to part complex pathogenesis (FCE). Fecal is a non-invasive biomarker for inflammation in humans dogs but has not yet been evaluated cats. We hypothesized that fecal (fCal) concentrations are increased FCE, correlate with clinical and/or histologic disease severity,...

Bacterial endometritis is one of the major problems in equine reproduction and usually treated with antimicrobial drugs. The study aimed to compare effects intrauterine ozone application systemic antibiotic treatment (trimethoprim-sulfadimethoxine) on bacterial growth possible side endometrium a clinical setting. Mares (n = 30) signs (positive uterine culture cytological findings) were assigned randomly different treatments: insufflation an ozone-air-mix (240 ml, 80 μg ozone/ml) twice at 48...

The family of paramyxoviruses has received growing attention as several new species have been identified recently, notably two different clusters in domestic cats, designated feline morbillivirus (FeMV) and paramyxovirus (FPaV). Their phylogenetic origin whether wild felids also harbor these viruses are currently unknown. Kidney samples from 35 guignas (Leopardus guigna), a felid Chile, were investigated for using consensus-RT-PCR. In addition, thirteen serum screened the presence...

Diagnosing chronic inflammatory enteropathies (CIE) in cats and differentiation from intestinal lymphoma (IL) using currently available diagnostics is challenging. Intestinally expressed S100/calgranulins, measured fecal samples, appear to be useful non-invasive biomarkers for canine CIE but have not been evaluated cats. We hypothesized S100/calgranulins play a role the pathogenesis of feline (FCE) correlate with clinical and/or histologic disease severity. This retrospective case-control...

The aims of this study were to evaluate histopathologic changes during the transition period, describe histopathological features metabotypes identified in Part I (Schären et al., 2021b), and investigate effects a metaphylactic treatment with butaphosphan cyanocobalamin (BCC) on liver parenchyma. Eighty German Holstein cows (mean 305-d production: 10,957 kg, range: 6,480-15,193 kg; mean lactation number: 3.9, 2-9) from commercial dairy farm Saxony, Germany, enrolled randomized, prospective,...

Streptococcus (S.) equi subspecies (subsp.) zooepidemicus is an important facultative pathogen in horses and can cause severe infections other species including humans. Facing the post-antibiotic era, novel antimicrobials are needed for fighting bacterial infections. Bacteriophages (phages) natural predators of bacteria discussed as a promising antimicrobial treatment option. The objective this study was to isolate characterize S. subsp. zooepidemicus- specific phages first time evaluate...

A melanoma of the upper eyelid was resected in a gray warmblood gelding. full functional could be obtained by completion sliding skin graft with free labial mucocutaneous transplantation to restore junction and decrease risk postoperative trichiasis.

Objective To describe the presentation, presurgical diagnostic findings, treatment, and outcome of horses with histologically confirmed, unilateral thyroid neoplasia. The complications, particularly laryngeal hemiplegia, were investigated. Study Design Retrospective case series. Animals Client‐owned (n=14). Methods Medical records presenting a mass due to neoplasia from 2003–2015 reviewed. Horses must have undergone preoperative clinical evaluations that included ultrasound examination upper...

Abstract Background Recumbent cows are a diagnostic challenge because of wide range differential diagnoses, which include trauma, neurological and metabolic disorders, malnutrition mineral deficiencies. This case report describes recumbent suckler that presented as herd problem. In addition to weakness due inanition, Cu Se deficiencies were considered possible aetiologies the recumbency. Furthermore, Trypanosoma (T.) theileri , blood parasite unknown importance in Germany, was detected some...

Prostatic carcinoma (PCA) is a rare but severe condition in dogs that similar to the androgen-independent form of PCA men. In contrast humans, difficult diagnose as reliable biomarkers, available for screening human medicine, are currently lacking small animal oncology. Calprotectin (S100A8/A9) and S100A12 Ca2+-binding proteins innate immune system with promising potential distinguish malignant from benign urogenital tract conditions, blood neutrophil-to-lymphocyte-ratio (NLR). However, both...

The mosquito-borne flavivirus Usutu virus (USUV) is responsible for countless deaths in both resident populations and birds kept outdoor aviaries. Since 2001, USUV outbreaks have attracted increased attention due to the rapid geographical spread of its close relationship West Nile (WNV), an emerging pathogen humans animals. Similar WNV, enzootic transmission cycle predominantly involves Culex spp. as vectors, whereas serve amplifying reservoir hosts. In Europe, USUV-associated disease are...

Contents The deep anoestrous phase in winter is part of the anovulatory season mares and bordered by autumn spring transitional periods ( ATP / STP ). To define an annual time span for effective prognostic biopsy sampling, aim this study was to provide a morphofunctional characterization endometrium during . outline both periods, endometrial specimens were taken September, October November n = 76) as well February, March April 184) with requirement detailed clinical documentation. Tissue...

Equine endometrial diseases are a frequent cause of subfertility causing financial loss.Degenerative and inflammatory often associated with alterations the innate immunity beta-defensin has been identified within equine endometrium.The aim this study was to further characterize expression protein in endometrium by immunohistochemistry.For situ investigations, samples were collected from 26 mares once at different stages oestrus cycle 3 repeatedly during same (days 0, 5, 10, 13, 16, 19 21;...

Contents To investigate the equine endometrium as close to in vivo situation possible, we established a coculture system for epithelial and stromal cells ( EC s/ SC s). s were isolated from nine endometrial tissue specimens. obtained glandular formations cultivated on one side of semipermeable membrane Millicell ® insert. After 2 days, (2 × 10 4 cells/membrane) seeded onto other same membrane. During cocultivation, low serum containing culture medium (Theuß et al., 2010) was supplemented...

Feline morbillivirus (FeMV) is a recently discovered virus belonging to the genus Morbillivirus of family Paramyxoviridae. Often, has been detected in urine cats with history urinary disease and worldwide distribution. Currently, it unclear which receptor uses enter target cells. Furthermore, many aspects FeMV biology vivo, including tissue tropism, pathogenesis, excretion natural host remain unclear. In this study we analyzed replication various cell lines. Secondly, tested if presence...

Urothelial carcinoma (UC) is the most common neoplasm of canine lower urinary tract, affecting approximately 2% dogs. Elderly female patients certain breeds are predisposed, and clinical signs UC can easily be confused with tract infection or urolithiasis. Diagnosis treatment challenging given lack disease-specific markers treatments. The S100A8/A9 complex S100A12 protein Ca2+-binding proteins expressed by cells innate immune system have shown promise as screening for UC....