A5040642354- Veterinary Oncology Research
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Infectious Diseases and Mycology
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- Oral and Maxillofacial Pathology
- S100 Proteins and Annexins
- Ear and Head Tumors
- Retinal Diseases and Treatments
- Blood groups and transfusion
- Microbial infections and disease research
- Nanoplatforms for cancer theranostics
- Veterinary Medicine and Surgery
- Advanced Fluorescence Microscopy Techniques
- Herpesvirus Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Cancer, Stress, Anesthesia, and Immune Response
- Genomics and Phylogenetic Studies
- Animal health and immunology
- Fungal Infections and Studies
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
Leipzig University
2016-2024
University of Veterinary Medicine Hannover, Foundation
2014-2024
RWTH Aachen University
2014-2017
University Medical Center Freiburg
2014
University of Veterinary Medicine
2014
Background The most common nasal cavity disease (ND) in dogs is the malignant tumor. Prognosis and survival after radiation therapy are reported to correlate with tumor size, therefore indirectly time diagnosis. Diagnosis of a requires imaging procedures under anesthesia. Thus, diagnostic serum markers urgently needed for early detection therapeutic monitoring. Materials methods This prospective, blinded study included discharge that completed comprehensive workup ND. Dogs were evaluated by...
Background . To evaluate the correlation between ERG, OCT, and microscopic findings in rd10 mouse. Methods C57BL/6J wild type mice were compared at age of 2, 3, 5, 7, 9, 12, 24, 48 weeks (each group<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>3</mml:mn></mml:math>) using full-field electroretinography (ERG), spectral domain Optical Coherence Tomography (sd-OCT), fluorescein angiography (FA), Hematoxylin & Eosin histology...
Abstract Background A multimodal approach for diagnostic tests under anesthesia is required to diagnose nasal cavity pathology (NP) reliably in dogs. Blood test results may provide clues the suspected NP. Methods This prospective blinded study assessed 72 dogs with chronic discharge due NPs, and 10 healthy as control group (CG). NPs were diagnosed using whole-body computed tomography (CT), upper airway endoscopy, examination of mucosal swabs by bacterial fungal culture, histopathological...
Purpose: To characterize the course of retinal degeneration in pink-eyed RCS rat vivo and vitro.Methods: Retinal function rats at age 2 to 100 weeks was determined using full-field electroretinography (ERG). morphology evaluated spectral domain Optical Coherence Tomography (sd-OCT) Fluorescence angiography (FA) as well postmortem immunohistochemistry (IH). As a control, non-dystrophic Wistar were analyzed.Results: showed an extinction ERG beginning with 4 weeks. In OCT, outer part retina...
Purpose.: To characterize the effects of intravitreal injections N-methyl-N-nitrosourea (MNU) in comparison to its systemic application as a measure inducing unilateral photoreceptor degeneration. Methods.: Eight-week-old male C57BL/6J mice received either intraperitoneal (three animals) or (24 MNU different concentrations and were observed over period 2 weeks using full-field electroretinography (ERG), spectral-domain optical coherence tomography (SD-OCT), immunohistochemistry. Results.:...
Retinal prostheses that are currently used to restore vision in patients suffering from retinal degeneration not adjusted the changes occurring during remodeling process of retina. Recent studies revealed abnormal rhythmic activity retina genetic mouse models retinitis pigmentosa. Here we describe this also a pharmacologically-induced (MNU) model degeneration. To investigate how affects excitability ganglion cells, recorded electrical whole mounted retinas rd10 mice and MNU-treated using...
Background Brachycephalic dog breeds have multiple skull malformations which may lead to anatomical changes in the external auditory canal. It is our frequent observation that otoscopic examination of ear these we are unable visualise tympanic membrane as a consequence extreme narrowing proximal Additionally brachycephalic dogs reportedly predisposed otitis externa (OE) and media. Objectives To characterizse transition cartilaginous canal bony meatus acusticus externus using computed...
Background Malignant (intra-) nasal tumors (NTs) are the most common cause of chronic discharge in dogs. Besides radiation therapy, palliative therapy is necessary some Therefore, studies on receptor expression have supported utility tyrosine kinase inhibitors (TKI) dogs with carcinomas. However, sarcomas lacking. Materials and methods This study evaluated vascular endothelial growth factor receptor-2 (VEGFR-2), epidermal (EGFR), cyclooxigenase-2 (COX-2), Ki-67, survivin E-cadherin...
Laryngeal paralysis (LP) is the inability to abduct arytenoid cartilages during inspiration, resulting in a partial complete airway obstruction and consequent respiratory distress. Different forms of LP with varying age onset exist dogs. Hereditary early were reported several dog breeds. In most breeds, hereditary associated other neurologic pathologies. Using genome-wide association study haplotype analyses, we mapped major genetic risk factor for an Miniature Bull Terriers ~1.3 Mb interval...
Retrospective evaluation of the diagnostic value bacterial culture nasal mucosal swabs and histopathologic assessment biopsies in dogs with discharge.Medical records predominant clinical sign discharge that were referred to ENT Unit Small Animal Department between January 2015 December 2016 reviewed.Data 85 evaluated. On basis results computed tomography (CT), rhinoscopy, a swab examination biopsies, assigned one six groups primary diseases: neoplasia (24/85, 28 %), oronasal defect (22/85,...
Urothelial carcinoma (UC) is the most common neoplasm of canine lower urinary tract, affecting approximately 2% dogs. Elderly female patients certain breeds are predisposed, and clinical signs UC can easily be confused with tract infection or urolithiasis. Diagnosis treatment challenging given lack disease-specific markers treatments. The S100A8/A9 complex S100A12 protein Ca2+-binding proteins expressed by cells innate immune system have shown promise as screening for UC....
Hintergrund Das Immunsuppressivum Cyclosporin A (CsA) wird bei der Katze zur Behandlung von immunvermittelten Krankheiten, wie hämolytischen Anämie, eingesetzt. Es sind tägliche Dosierungen 5–20 mg/kg beschrieben. Nach Applikation liegen interindividuelle Schwankungen im CsA Blutspiegel vor. ist nicht bekannt, wann "Steady-state"-Bedingungen erreicht werden. Ziel dieser Studie war es deshalb, die Entwicklung CsA-Blutspiegel während eines hochdosierten Therapieschemas zu bewerten, und...
Zusammenfassung Eine 2-jährige Norwegische Waldkatze wurde aufgrund von bilateralem, eitrigem Nasenausfluss und Stertor vorgestellt. Computertomografie (CT) des Kopfes zeigte eine intranasale Masse der linken Nasenhöhle, die sich bis hinter Tubenöffnungen erstreckte den Nasenrachen vollständig verlegte. Die Rhinoskopie bestätigte rosafarbene, speckige Masse. In CT zeigten beide Kompartimente rechten Mittelohres mit weichteilisodensem Material gefüllt. knöcherne Umrandung war nicht verändert....
In this prospective blinded study, canine C-reactive protein (c-CRP), haptoglobin (HPT), and 25-hydroxyvitamin-D (25(OH)D) were investigated for their diagnostic value in 55 dogs with nasal cavity disease (ND). After comprehensive diagnostics including a culture-dependent microbiological examination (ME) of swabs, 17 excluded due to additionally detected systemic diseases or steroid pre-treatment. Included 25 malignant ND (13 carcinomas 12 sarcomas) 30 benign (7 tumors, 13 idiopathic...
Background Cyclosporine A (CsA) is used as a steroid-sparing or alternative immunosuppressing agent in cats with various immune-mediated diseases such hemolytic anemia. Daily treatment dosages of 5–20 mg/kg have been described. Interindividual variations CsA blood levels are known to occur. To determine when steady-state conditions reached and thus the earliest advisable time for monitoring during course treatment, prospective experimental study was conducted six healthy adult Domestic...
Den harmlosen Schnupfen oder eine primäre bakterielle Rhinitis gibt es beim Hund als Grund für chronischen Nasenausfluss nicht. Eine blinde antibiotische symptomatische Therapie ist daher nicht sinnvoll und führt nur zu Zeitverlust einer Verschlechterung der ursächlichen Erkrankung. Stattdessen wird zügige Diagnostik in Narkose, möglichst mittels CT Endoskopie empfohlen.
<b>Hintergrund:</b> Antibiotikaresistente Erreger werden weltweit ein immer größeres Problem. Das Paradebeispiel ist der Methicillin-resistente Staphylococcus aureus, MRSA. Welche Rolle spielt er tatsächlich auf einer viszeralchirurgischen Intensivstation? <b>Patienten/Material und Methoden:</b> In einem 7-Jahres-Zeitraum wurden 20-Betten-, rein chirurgischen Intensiv-/Intermediate-Care-Station insgesamt 14 976 Patienten behandelt. Nur 98 MRSA-positive identifiziert, davon waren 56 (57 %)...
Prostatakarzinome (PCA) sind maligne Tumorerkrankungen, die beim Hund schwierig zu diagnostizieren sind, da verlässliche Screening-Tests fehlen. S100/Calgranuline (calprotectin, S100A12) der angeborenen Immunität haben vielversprechendes Potenzial zur Abgrenzung benigner vs. maligner Prozesse im Urogenitaltrakt des Hundes, gleich wie Neutrophil-to-lymphocyte ratio (NLR) Blut.
Odontogenic cysts may be of developmental or inflammatory origin. They are frequently observed in brachycephalic dogs. Due to their expansive growth, the maxilla extend into nasal cavity, obstruct airway and cause discharge. Epithelial lead a comparable clinical picture. A new endonasal endoscopic intervention for removal these is described.Four dogs (Boxer, Chihuahua, French bulldog, Pug) with unilateral obstructing cavity were included study. The animals underwent examination, computed...
Hunde sind obligate Nasenatmer. Zusätzlich zu ihren klassischen respiratorischen und olfaktorischen Funktionen hat die Hundenase zentrale Aufgaben in der kaninen Thermoregulation. Als eine Folge des arttypischen Schnüffelns ist Nasenschleimhaut Kontakt mit vielen potentiellen Krankheitserregern. Dennoch primäre bakterielle Rhinitis beim Hund bisher nicht beschrieben worden. Bakterielle Rhinitiden Regel Folgeerkrankungen, z.B. von oro-nasalen Defekten oder Tumoren Nase.