A5025717652- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Species Distribution and Climate Change
- Phytochemicals and Antioxidant Activities
- Optical Imaging and Spectroscopy Techniques
- Mycorrhizal Fungi and Plant Interactions
- Per- and polyfluoroalkyl substances research
- Microbial Metabolism and Applications
- AI in cancer detection
- Antimicrobial Peptides and Activities
- Genomics and Phylogenetic Studies
- Ultrasound Imaging and Elastography
- Microbial Community Ecology and Physiology
- Fluorine in Organic Chemistry
- Pharmacogenetics and Drug Metabolism
- Plant Diversity and Evolution
- Cardiovascular Health and Disease Prevention
- Chemical Synthesis and Analysis
- Vascular Procedures and Complications
- Bacterial biofilms and quorum sensing
- Plant Pathogenic Bacteria Studies
Tianjin University
2018-2024
Tianjin University of Science and Technology
2021-2024
Concordia University
2021
University College London
2005-2018
Tripler Army Medical Center
2018
Hospital of the University of Pennsylvania
2017
University of Hawaii at Hilo
2012-2015
University College Dublin
2008-2013
Scripps Institution of Oceanography
2008-2011
University of California, San Diego
2010-2011
In all probability, natural selection began as ancient marine microorganisms were required to compete for limited resources. These pressures resulted in the evolution of diverse genetically encoded small molecules with a variety ecological and metabolic roles. Remarkably, many these same biologically active have potential utility modern medicine biomedical research. The most promising products often derive from organisms richly populated by associated (e.g., sponges ascidians), there is...
As part of a continuing program to identify novel treatments for neglected parasitic diseases, the Panama International Cooperative Biodiversity Group (ICBG) has been investigating antimalarial potential secondary metabolites from Panamanian marine cyanobacteria. From over 60 strains cyanobacteria evaluated in our biological screens, organic extract Schizothrix species tropical reef near Piedras Gallinas (Caribbean coast Panama) showed potent initial activity against W2 chloroquine-resistant...
An easily accessible taxonomic knowledge base is critically important for all biodiversity-related sciences. At present, information organized and regulated by a system of rules conventions that date back to the introduction binomial nomenclature Linnaeus. The taxonomy any particular group organisms comprises sum in literature, supported designated type specimens major collections. In this article, way modern means disseminating will change practice taxonomy, Internet, explored. Basic...
Bacteria of the genus Frankia are mycelium-forming actinomycetes that found as nitrogen-fixing facultative symbionts actinorhizal plants. Although soil-dwelling well-known producers bioactive compounds, has largely gone uninvestigated for this potential. Bioinformatic analysis genome sequences strains ACN14a, CcI3, and EAN1pec revealed an unexpected number secondary metabolic biosynthesis gene clusters. Our led to identification at least 65 biosynthetic clusters, vast majority which appear...
Detailed chemical analysis of the solid phase fermentation an Australian Penicillium citrinum isolate has returned known compounds citrinin (1), phenol A acid (6), dihydrocitrinone (7) and dihydrocitrinin (8), together with a novel cytotoxic dimer, dicitrinin (5). Dicitrinin (5) was determined to be dimerised artefact major co-metabolite citrinin, its structure solved by spectroscopic modification. Analysis products encountered during controlled decomposition led discovery additional dimers...
A Papua New Guinea field collection of the marine cyanobacterium Blennothrix cantharidosmum was investigated for its cytotoxic constituents. Bioassay-guided isolation defined components as known compounds lyngbyastatins 1 and 3. However, six new acyl proline derivatives, tumonoic acids D-I, plus acid were also isolated. Their planar structures from NMR MS data, while their stereostructures followed a series chiral chromatographies, degradation sequences, synthetic approaches. The tested in...
The association of high amplitude echoes returned from the liver and cirrhosis is well recognized. There have been no reports in literature as to overall incidence this finding clinical situation. We report our experience a series 67 patients with proven who had biopsy an ultrasound examination within three months one another. In 43 was suggested by recognition bright echo pattern. 23 pattern normal, although additional relevant information shown half group. detailed pathology has analysed...
Research Article| November 01 1964 Determination of Succinic Acid by an Enzymic Method B. Clark; Clark Search for other works this author on: This Site PubMed Google Scholar J. W. Porteous Biochem J (1964) 93 (2): 21C–22C. https://doi.org/10.1042/bj0930021C Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn MailTo Cite Get Permissions Citation Clark, Porteous; Method. 1 1964; doi: Download citation file: Ris (Zotero)...
An Australian isolate of the soil ascomycete Gymnoascus reessii yielded a series cytotoxic metabolites, including known polyenylpyrroles rumbrin (1) and auxarconjugatin A (2), new stereoisomer 12E-isorumbrin (3), as well an unprecedented class polyenylfurans exemplified by gymnoconjugatins (4) B (5). Structures were assigned with detailed spectroscopic analysis.
Three new aromatic butenolides, gymnoascolides A−C (1−3), have been isolated from the Australian soil ascomycete Gymnoascus reessii and assigned structures on basis of detailed spectroscopic analysis. The absolute configurations B (2) C (3) at C-5 were solved using a combination chemical derivatization quantum simulations.
The Internet has the potential to provide wider access biological taxonomy, knowledge base of which is currently fragmented across a large number ink-on-paper publications dating from middle eighteenth century. A system (the CATE project) proposed in consensus or consolidated taxonomies are presented form Web-based revisions. workflow designed allow community offer, online, additions and taxonomic changes ('proposals') (e.g. new species synonymies). means quality control online peer review...
Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity A is dependent on D-tyrosine residue and presence fluorotyrosine may result in an improvement biological properties this lipopeptide. might also be used as a probe for studying its interaction membranes.
The new isoprenylated diketopiperazine roquefortine E (6) has been isolated from an Australian soil isolate of the ascomycete Gymnoascus reessii. known fungal metabolite C (1) was also recovered as major antibacterial principle, and all structures were assigned by detailed spectroscopic analysis.
Elastic scattering spectroscopy (ESS) may be used to detect high-grade dysplasia (HGD) or cancer in Barrett's esophagus (BE). When spectra are measured vivo by a hand-held optical probe, variability among replicated from the same site can hinder development of diagnostic model for risk. An experiment was carried out on excised tissue investigate how two potential sources this variability, pressure and angle, influence spectral results were compared with variations observed collected patients...
Synthesis of a recently discovered S-methylated quinolone natural product (1) was carried out, in addition to the production range 2-substituted 4-quinolone derivatives (2–11). Two approaches were used: (i) base-catalyzed cyclization N-(ketoaryl)amides; (ii) attachment substituent core via Suzuki–Miyaura cross-coupling. Also produced small suite related 2(1H)-quinolones (12–19). The synthesized compounds assessed for their antimicrobial properties. alkene-substituted 8 significantly...
Chemical analysis of a solid phase fermentation an Australian Penicillium citrinum strain has returned all known examples rare class N-methyl quinolone lactams, quinolactacins A2 (1), B2 (2), C2 (3) and A1 (4), together with the new B1 (5), C1 (6), D1 (7) D2 (8), novel derivatives quinolonimide (9) quinolonic acid (10). Complete stereostructures were assigned to these compounds by detailed spectroscopic chemical interconversion. Carefully controlled monitored decomposition studies have...
A novel method for rapidly detecting metastatic breast cancer within excised sentinel lymph node(s) of the axilla is presented. Elastic scattering spectroscopy (ESS) a point-contact technique that collects broadband optical spectra sensitive to absorption and tissue. statistical discrimination algorithm was generated from training set nearly 3000 clinical used test collected an independent nodes. Freshly nodes were bivalved mounted under fiber-optic plate. Stepper motors raster-scanned probe...