A5066872816- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Mycobacterium research and diagnosis
- Pathogenesis and Treatment of Hiccups
- Plant-based Medicinal Research
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Helicobacter pylori-related gastroenterology studies
- Ginger and Zingiberaceae research
- Pharmacy and Medical Practices
- Phytochemistry and biological activity of medicinal plants
- Influenza Virus Research Studies
- Medical Research and Treatments
- Pharmacology and Obesity Treatment
- Hepatitis C virus research
- Complementary and Alternative Medicine Studies
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Hormonal Regulation and Hypertension
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Neurological Disease Mechanisms and Treatments
- Respiratory viral infections research
Universitat de Barcelona
2023
Gunma University
2002-2006
Tohoku Medical and Pharmaceutical University
1999-2003
University of Toyama
2001
Suwa Red Cross Hospital
1995
Abstract It has been previously reported that green‐tea extract (GTE) inhibits the growth of influenza virus by preventing its adsorption. In this study, we further investigated whether GTE exerts an additional inhibitory effect on acidification intracellular compartments such as endosomes and lysosomes (referred to ELS) thereby A B viruses in Madin‐Darby canine kidney cells. The vital fluorescence microscopic study showed inhibited ELS a concentration‐dependent manner. Moreover, was equally...
We investigated the effect of ferulic acid (FA) and isoferulic (IFA), which are main active components rhizoma Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on production macrophage inflammatory protein-2 (MIR-2) a murine cell line, RAW264.7, response to respiratory syncytial virus (RSV) infection. Following exposure cells RSV for 20h, MIP-2 level condition medium was increased about 20 ng/ml, although this mock-infected...
ABSTRACT We investigated the effect of anti-macrophage inflammatory protein 2 immunoglobulin G (aMIP-2 IgG) on progression influenza virus-induced pneumonia in mice. When mice were infected with a mouse lung-adapted strain A/PR/8/34 virus by intranasal inoculation, neutrophil counts bronchoalveolar lavage fluid (BALF) increased parallel kinetics MIP-2 production, which peaked days after infection. After intracutaneous injection dose 10 or 100 μg aMIP-2 IgG once day 0 and 1, BALF reduced to...
Abstract Intravascular lymphomatosis (IVL) is a rare systemic disease characterized by proliferation of lymphoid cells within the lumina small arteries, veins, and capillaries. Diagnosis requires skin, liver, lung, bone marrow, renal, meningeal, or brain vessel biopsy but often made only when illness has progressed post mortem because early involvement organs was not evident. We report case IVL presenting as fever unknown origin (FUO). In this case, gallium scintigraphy computed tomography...
We investigated whether (+)-catechin, a building block of tannins contained in the extract Ephedrae herba (EHext), exerts an inhibitory effect on acidification intracellular compartments such as endosomes and lysosomes (referred to ELS), thereby inhibits growth influenza A PR/8/34 (PR8) virus (H1N1 subtype) Madin-Darby canine kidney cells. The vital fluorescence microscopic study with acridine orange showed that 1-h treatment (+)-catechin inhibited ELS concentration-dependent manner (1.0 -...
We have investigated the effect of Juzen-taiho-to (TJ-48) on inducible NO synthase (iNOS) expression and nitric oxide (NO) production in RAW264.7 cells, a murine macrophage cell line. TJ-48-lipopolysaccharide (LPS) combination induced iNOS mRNA earlier, stronger remained longer that paralleled but with higher compared to LPS stimulation. TJ-48 itself showed no either or expression. This phenomenon could be considered contribute, at least part, beneficial effects through iNOS-mediated...
Abstract Kampo medicines have been used to treat patients with psychogenic disorders from ancient times. In the present report cases are described of four panic disorder successfully treated medicines. These fulfilled Diagnostic and Statistical Manual Mental Disorders (DSM) criteria for agoraphobia. The medicine Kami‐shoyo‐san (TJ‐24) relieved attacks, anticipatory anxiety agoraphobia in two patients, Hange‐koboku‐to (TJ‐16) these symptoms other patients. whom was effective were older...
The inhibitory effect of Zingiber officinale Rosc (ZOR), an Oriental traditional herbal medicine, on the growth influenza A/Aichi/2/68 (Aichi) virus was investigated in Madin-Darby canine kidney (MDCK) cells. Direct addition ZOR (0.1 ~ 100 μ g/ml ) to infected cells did not have any effect. However, ZOR-induced conditioned medium (ZOR-CM) RAW cells, a murine macrophage (Mφ) cell line, exhibited apparent MDCK without cytotoxicity. In accordance with time-dependent ZOR-CM, it has been...
甘草による偽アルドステロン症の頻度については十分にわかっていない。われわれは甘草の1日量と偽アルドステロン症の頻度の関係について,過去の臨床研究を調査した。甘草を1日1g 使用した患者での偽アルドステロン症の頻度は1.0%(平均)であった。1日2g,4g,6g での頻度はそれぞれ1.7%(平均),3.3%,11.1%(平均)であった。過去の文献において,偽アルドステロン症発症頻度の用量依存的な傾向が示唆された。
ABSTRACT We performed lymphocyte transformation tests (LTTs) for toki (angelicae radix) and ogon (scutellariae on first-visit patients who had never taken Kampo medicines. LTTs both herbs were positive in 12 of 14 patients, suggesting that these are unreliable the diagnosis medicine-induced liver injury.
Abstract Background and Aim Changes in treatment protocols for patients with diabetes mellitus (DM) may influence the functions of digestive tract. This study examined possible clinical factors associated symptoms constipation DM. Methods was a multicenter study. Participants were consecutive Japanese undergoing type 1 or 2 Constipation evaluated using gastrointestinal symptom rating scale. Diabetic neuropathy by presence absence peripheral lower limbs. Results Of 419 participants, 258 men...
We have investigated the effect of Zingiber offifinale Rosc. (ZOR) on macrophage-inducible nitric oxide (NO) synthase (macNOS) mRNA expression and NO production in RAW264.7 cells, a murine macrophage cell line; 100 μg/ml ZOR can induce macNOS expression, but induction effects at dose below 10 were weak or negligible. Kinetic studies showed that be detected from 4 hours to 24 after dosing, with peak 8 hours. In accordance concentrations increased 3.4 μM 2 almost 150 hours, reflecting longer...
In vitro mutagenic effects have been reported for ingredients contained in rhubarb. Therefore, rhubarb (Rhei Rhizoma) as an anthranoid laxative could be associated with a risk of developing gastric cancer well colorectal cancer. We are not aware any reports that examined the relationship between use and development During period 1979 1999, we treated 14,616 patients using various Kampo medicines, which sometimes present study, determined whether patients, diagnosed during had administered...
In vitro mitogenic activity of 16 herbs and 3 Kampo (herbal medicine) formulae have been reported in experimental studies. It is not known how many total activity. Lymphocyte transformation test (LTT) generally utilized to diagnose drug-induced liver injury. LTT, assessed by measuring 3H-thymidine incorporation. The objective the present study was determine which caused false-positivity on LTT. We examined 2496 summaries all admission records from 1979 1999 our department. selected patients...
Background : Isoferulic acid (IFA) is a main active ingredient of the rhizoma Cimicifuga heracleifolia , which used frequently in Japanese traditional medicine as an anti‐inflammatory drug. It has been revealed that IFA inhibits production macrophage inflammatory protein‐2 (MIP‐2), murine counterpart chemokine family may contribute to pathogenesis diseases through chemotactic activity for and immune effector cells. Aim study In this study, we investigated therapeutic effect on progression...
Interleukin (IL)-15 has emerged as a key regulator of both natural killer (NK) cell differentiation and activation. The aim the present study was to investigate expansion population cells expressing killer-cell immunoglobulin-like receptors (CD158a CD158b) in human peripheral lymphocytes by treatment with IL-15. One million were cultured RPMI1640 medium alone or containing IL-2 at 100 U/ml IL-15 0.1, 1.0, 10.0 ng/ml for 48 h. After each incubation, we assessed killing activity...
The purpose of this study was to determine if the adverse effects interferon (IFN) in hepatitis C patients could be reduced by treatment with Japanese Oriental (Kampo) medicine. Twelve chronic were treated a combination IFN-β and either Mao-to or Dai-seiryu-to (groups A B), 16 alone (group C). administered eight four groups B, respectively. Adverse evaluated clinical laboratory examinations. severity symptoms daily self-classified into categories (1: none, 2: very slight, 3: moderate, 4:...