A5021900830- Science and Education Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Women's cancer prevention and management
- Cell death mechanisms and regulation
- Reproductive tract infections research
- Immune Response and Inflammation
- HIV/AIDS Research and Interventions
- Whipple's Disease and Interleukins
- Indigenous Health and Education
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Tuberculosis
- Health and Wellbeing Research
- Rural and Ethnic Education
Universidade Federal do Pará
2016-2023
Some genetic variations in cytokine genes can alter their expression and influence the evolution of Mycobacterium tuberculosis (Mtb) infection. This study aimed to investigate association polymorphisms variability plasma levels cytokines with development (TB) latent infection (LTBI). Blood samples from 245 patients TB, 80 LTBI, healthy controls (n = 100) were included. Genotyping IFNG +874A/T, IL6 -174G/C, IL4 -590C/T, IL10 -1082A/G was performed by real-time PCR, determined flow cytometry....
OBJETIVOS: Descrever a prevalência e os fatores associados à infecção endocervical por Chlamydia trachomatis em estudantes de uma universidade da capital três seus campi do interior estado Pará, Amazônia, Brasil.
TNF-α is a Th1 cytokine profile active in the control of Mycobacterium tuberculosis infection, IL-10 associated with persistence bacterial infection. The aim study was to investigate association TNFA -308G/A and IL10 -819C/T polymorphisms gene expression levels pulmonary extrapulmonary (n = 200) 200). individuals were submitted genotyping quantification performed by real-time quantitative polymerase chain reaction (qPCR). No observed between frequencies evaluated tuberculosis. frequency...
Several factors are associated with the development of different clinical forms tuberculosis (TB). The present study evaluated epidemiological variables and cytokine levels in samples from 89 patients TB (75 pulmonary 14 extrapulmonary TB) 45 controls. Cytokines were measured by flow cytometry (Human Th1/Th2/Th17 Cytometric Bead Array kit). group had a higher frequency individuals who 39 years age or older, married, primary education illiterate lower family income (p < 0.05). All reported...
Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an important immune mechanism against infection. This study investigated the association (TB) with presence polymorphisms FAS -670A/G and FASL -124A/G, levels sFas sFasL, gene expression cytokines. Samples 200 individuals diagnosed TB healthy controls were evaluated. Real-time PCR (genotyping expression) ELISA (dosages sFas, IFN-γ, IL-10) tests performed. There was no -124A/G TB. The group exhibited high plasma...
O sistema Fas-FasL de membrana celular é um importante mediador apoptose células infectadas. A macrófagos infectados pelo Mycobacterium tuberculosis uma estratégia imunológica proteção contra a tuberculose (TB). Objetivo: Investigar influência dos níveis expressão genes FAS e FASL no estabelecimento da TB em 20 amostras pacientes diagnosticados com 22 controle. Foram coletadas sangue, as quais foram submetidas à extração mRNA transcrição reversa, para obtenção cDNA, utilizado quantificação...
Os principais desafios enfrentados pelos serviços de saúde para o enfrentamento das infecções sexualmente transmissíveis, estão relacionados a oferecer garantia acesso aos direitos cidadania, melhor qualidade vida, ao tratamento e aconselhamento. No que concerne região norte, em especial metrópole Belém, processo urbanização deflagrou contradições diversas ordens conforme cidade cresceu. locais mais afastados foram ocupados pelas populações menor renda, refletiu diretamente situações...