A5035521142- T-cell and Retrovirus Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- HIV Research and Treatment
- Hepatitis C virus research
- Vector-Borne Animal Diseases
- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Inflammasome and immune disorders
- interferon and immune responses
- Hepatitis B Virus Studies
- Syphilis Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- Complement system in diseases
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Sex work and related issues
Universidade Federal do Pará
2016-2025
Universidade Federal de Uberlândia
2020
The duration and severity of COVID-19 are related to age, comorbidities, cytokine synthesis. This study evaluated the impact these factors on patients with clinical presentations in a Brazilian cohort. A total 317 diagnosed were included; cases distributed according status as severe (n=91), moderate (n=56) mild (n=170). Of patients, 92 had acute at sample collection, 90 already recovered from without sequelae, 135 sequelae (long COVID syndrome). In group, form higher IL-6 levels (p=0.0260)....
Abstract The cGAS-STING pathway appears to contribute dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related long COVID are still being investigated. In the present study, we evaluated association of cGAS and STING gene expression levels plasma IFN-α, TNF-α IL-6 with COVID-19 severity in acute infection COVID, based on analysis blood samples from 148 individuals, 87 61 post-COVID-19 period. Quantification was performed by real-time PCR,...
Studies have shown that the human T-lymphotropic virus 2 (HTLV-2) is endemic in several indigenous populations of Brazilian Amazon and molecular analyses exclusive presence HTLV-2 subtype 2c among groups this geographical region. The present study characterizes prevalence infection three new villages Xikrin tribe, Kayapo group, according to their distribution by sex age. included 263 samples from individuals Kateté, Djujeko Oodjã villages. Plasma were tested for anti-HTLV-1/2 antibodies...
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic severe coronavirus disease 2019 (COVID-19). In this study, we investigated influence polymorphisms FAS FASL genes, gene expression, plasma cytokine levels on COVID-19 severity long COVID occurrence. A total 116 individuals with 254 non-severe form were evaluated. post-COVID-19 period, samples from 196 67 people who did not have included. Genotyping...
Introduction Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, may influence synthesis inflammatory cytokines. This study investigated association MBL2 gene polymorphisms with plasma levels MBL cytokines COVID-19. Methods Blood samples from 385 individuals (208 acute COVID-19 117 post-COVID-19) were subjected real-time PCR genotyping. Plasma measurements performed by enzyme-linked...
Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, evaluation influence polymorphisms key genes IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, rs7730934) at IL6. IL6R IL6ST genes, respectively, 227 patients (132 hospitalized 95 non-hospitalized). Genotype frequencies...
Abstract The description of the first human retrovirus, T-lymphotropic virus 1 (HTLV-1), was soon associated with an aggressive lymphoma and a chronic inflammatory neurodegenerative disease. Later, other clinical manifestations were described, affecting diverse target organs in body showing enormous burden carried by diseases. epidemiology HTLV-1 HTLV-2 showed that they largely distributed around world, although it is possible to locate geographical areas pockets low very high prevalence...
Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed 199 COVID (LC) patients cohort 79 COVID-19 whose follow-up by over six months did not reveal any evidence (NLC) were investigated detect genetic susceptibility COVID. Ten located thrombophilia-related genes genotyped real time PCR. In terms clinical outcomes, LC presented higher prevalence heart disease as...
A persistent state of inflammation has been reported during the COVID-19 pandemic. This study aimed to assess short-term heart rate variability (HRV), peripheral body temperature, and serum cytokine levels in patients with long COVID. We evaluated 202 COVID symptoms categorized them according duration their (≤120 days, n = 81; >120 121), addition 95 healthy individuals selected as controls. All HRV variables differed significantly between control group ≤120 days (p < 0.05), participants had...
Abstract Background In this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological characteristics, severity. Methods The study recruited 200 aged 18 years or older both sexes diagnosed COVID-19. Of initially selected, 135 individuals who underwent serological testing for...
Some genetic variations in cytokine genes can alter their expression and influence the evolution of Mycobacterium tuberculosis (Mtb) infection. This study aimed to investigate association polymorphisms variability plasma levels cytokines with development (TB) latent infection (LTBI). Blood samples from 245 patients TB, 80 LTBI, healthy controls (n = 100) were included. Genotyping IFNG +874A/T, IL6 -174G/C, IL4 -590C/T, IL10 -1082A/G was performed by real-time PCR, determined flow cytometry....
Bacillus Calmette-Guérin (BCG) injected during the COVID-19 convalescence period was safe and enhanced recovery from anosmia dysgeusia in acute phase.
Contact with HCV triggers the activation of innate mechanisms responsible for initial infection control. Host cells expressed extra- or intracellularly molecules that promote recognition pathogen-associated molecular patterns (PAMPs). Toll-like receptor 4 (TLR4), mannose-binding lectin (MBL) and C-reactive protein (CRP) are available PAMP recognition. The present study evaluated TLR4, MBL CRP gene expression in hepatic tissue chronic carriers (n = 22) association pathogenesis as well...
The present study evaluated the frequency of seropositivity for anti-SARS-CoV-2 (S1 and S2) total antibodies (receptor binding domain-RBD-S1) neutralizing in individuals vaccinated with immunizing agent Coronavac. This was a cross-sectional involving 358 divided into two groups. Group 1 consisted 205 volunteers who were tested antibodies; group 2 153 presence antibodies. Seropositivity greater than 70% both groups, although 17.6% 20.9% showed no or antibody reactivity, respectively....
HTLV-1 infections are persistent and frequently latent; however, productive trigger different types of immunological responses that utilize cytokines to control infection. The present study investigated the role IFNG +874A/T polymorphisms among 153 HTLV-1-infected individuals (33 clinically diagnosed with TSP/HAM, 22 rheumatologic manifestations, 2 dermatitis, 1 uveitis, 95 asymptomatic patients) 300 healthy individuals. Genotyping proviral load assessment were performed using real-time PCR...
Atherosclerosis is a progressive disease characterized by chronic inflammation of the arterial walls, associated with genetic and infectious factors. The present study investigated involvement Chlamydia trachomatis C. pneumoniae infections immunological markers (C-reactive protein, CRP, TNF-α, IL-6, IL-8, IL-10) in process atherosclerosis. evaluation included 159 patients for surgical revascularization (CAD) 71 heart valve (HVD) at three hospitals Belém, Brazil. control group (CG) comprised...
The present study evaluated the
Introduction Human T-lymphotropic virus 2 (HTLV-2) has been described for more than 30 years as an endemic infection in Brazilian indigenous populations, with its occurrence varying by age and sex, maintained mainly sexual intercourse mother-to-child transmission, favoring intrafamilial aggregation. Methods The epidemiological scenario of HTLV-2 among communities the Amazon region Brazil (ARB), number retrospective positive blood samples increasing 50 years. Results Five publications were...