A5033281278- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Leptospirosis research and findings
- Education during COVID-19 pandemic
- Zoonotic diseases and public health
- Indigenous Health and Education
- Syphilis Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Polyomavirus and related diseases
- Phagocytosis and Immune Regulation
- Mosquito-borne diseases and control
- Dialysis and Renal Disease Management
- COVID-19 Impact on Reproduction
- Public Health in Brazil
- Healthcare Regulation
- Obesity, Physical Activity, Diet
- Full-Duplex Wireless Communications
- HIV Research and Treatment
- Global Public Health Policies and Epidemiology
Universidade Federal do Pará
2016-2025
Abstract The cGAS-STING pathway appears to contribute dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related long COVID are still being investigated. In the present study, we evaluated association of cGAS and STING gene expression levels plasma IFN-α, TNF-α IL-6 with COVID-19 severity in acute infection COVID, based on analysis blood samples from 148 individuals, 87 61 post-COVID-19 period. Quantification was performed by real-time PCR,...
Studies have shown that the human T-lymphotropic virus 2 (HTLV-2) is endemic in several indigenous populations of Brazilian Amazon and molecular analyses exclusive presence HTLV-2 subtype 2c among groups this geographical region. The present study characterizes prevalence infection three new villages Xikrin tribe, Kayapo group, according to their distribution by sex age. included 263 samples from individuals Kateté, Djujeko Oodjã villages. Plasma were tested for anti-HTLV-1/2 antibodies...
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic severe coronavirus disease 2019 (COVID-19). In this study, we investigated influence polymorphisms FAS FASL genes, gene expression, plasma cytokine levels on COVID-19 severity long COVID occurrence. A total 116 individuals with 254 non-severe form were evaluated. post-COVID-19 period, samples from 196 67 people who did not have included. Genotyping...
Background/Objectives: The evaluation of the efficacy COVID-19 vaccination in immunocompromised individuals, such as people living with HIV/AIDS (PLWH), still is great global importance. present study aimed to describe presence anti-SARS-CoV-2 IgG antibodies PLWH vaccinated and unvaccinated against city Belém, northern Brazil. Methods: A cross-sectional involving 510 was conducted from December 2021 May 2022. Participants answered a sociodemographic questionnaire subsequently underwent an...
A pandemia de COVID-19, causada pelo SARS-CoV-2, destacou-se pela transmissão eficiente através secreções contaminadas e capacidade infecção assintomática. doença afeta principalmente os pulmões, mas também pode causar complicações sistêmicas persistentes, incluindo o sistema neurológico, como na síndrome pós-COVID-19. Até 2023, Brasil registrou mais 33 milhões casos, com significativa incidência no Estado do Pará Região Metropolitana Belém (RMB), destacando-se um dos principais focos da...
HTLV-1/2 infection is endemic in Indigenous peoples of the Americas. Its origin attributed to migratory flow Amerindian ancestral peoples. The present study aimed investigate seroprevalence Brazilian Amazon. A total 3350 people belonging 15 communities were investigated. investigation was performed using serological (ELISA), molecular (qPCR) and confirmatory (Western blot and/or Inno-Lia) tests detect differentiate infection. 8.3% for infection, with 0.1% individuals seropositive HTLV-1 8.1%...
Metabolic syndrome (MS) plays a key role in the origin of cardiovascular diseases. Studies on MS Brazil are recent, and its epidemiology more isolated regions such as Amazon is still unknown. The study aimed to estimate prevalence associated factors adults Brazilian Amazon. This was conducted 2012–2013. It cross-sectional population-based study, involving 787 randomly selected from urban area four cities state Pará, Eastern participants underwent anthropometric measurements, laboratory...
Introduction Human T-lymphotropic virus 2 (HTLV-2) has been described for more than 30 years as an endemic infection in Brazilian indigenous populations, with its occurrence varying by age and sex, maintained mainly sexual intercourse mother-to-child transmission, favoring intrafamilial aggregation. Methods The epidemiological scenario of HTLV-2 among communities the Amazon region Brazil (ARB), number retrospective positive blood samples increasing 50 years. Results Five publications were...
This study aimed to describe the prevalence of HTLV-1/2 in quilombola communities state Pará and investigate possible sociodemographic risk factors associated with infection, as well trace occurrence familial transmission virus. A total 310 individuals living eight quilombos located (northern Brazil) were investigated for presence anti-HTLV-1/2 antibodies using an enzyme-linked immunosorbent assay (ELISA), positive samples confirmed Western blot and/or real-time quantitative polymerase chain...
Introduction TLR7 detects the presence of single-stranded RNA (ssRNA) viruses, including human T-lymphotropic virus 1 (HTLV-1), and triggers antiviral inflammatory responses that are responsible for infection control. Genetic variations in gene may alter cytokine production influence course HTLV-1 infection. In present study, associations polymorphisms with HTLV-1-related symptoms, receptor expression levels, IFN-α TNF-α levels proviral load were investigated. Methods Blood samples from 159...
To identify the prevalence of infection in urban area capital city Belém, Brazil, Laboratory Virology Federal University Pará implemented, as a public service, serological screening for human T-lymphotropic viruses 1 and 2 (HTLV-1/2) and, if necessary, counseling service referral to specialized medical care. The project is funded by National Council Science Technology, Ministry Health Brazil Pan American Organization.From January 2020 June 2021, 1,572 individuals both sexes were approached...
Antiretroviral therapy (ART) improves the quality of life people living with HIV-1 (PLHIV) and reduces mortality rate, but some individuals may develop metabolic abnormalities. This study evaluated changes in nutritional status biochemistry PLHIV on antiretroviral a cohort that had not previously received ART to follow up these for 24 months after starting treatment. The initial consisted 110 ended 42 people, assessed by physical examination. A biochemical assay was performed using...
Abstract Interleukin-6 have been recognized as a major role player in COVID-19 severity, being an important regulator of cytokine storm. Hence, the evaluation influence polymorphisms key genes IL-6 pathway, namely IL6, IL6R and IL6ST , may provide valuable prognostic/predictive biomarkers on COVID-19. The present cross-sectional study genotyped three Single Nucleotide Polymorphisms - SNPs (rs1800795, rs2228145 rs7730934) at genes, respectively, 227 patients (132 hospitalized 95...
Human T-lymphotropic viruses 1 and 2 (HTLV-1 HTLV-2) infection has been described in several Amazonian populations; however, there is still a lack of data on the prevalence virus riparian populations living rural areas state Pará. The present study aimed to evaluate HTLV-1/2 four riverine communities one area Pará describe possible risk factors for infection. A total 907 individuals responded an epidemiological survey gave blood samples collected anti-HTLV-1/2 antibodies by immunoenzymatic...
Brazil has registered more than 62,000 confirmed cases of leptospirosis between 2001 and 2017, with 2,000 in the State Pará. Despite a large number cases, no study been conducted to trace spatio-temporal profile disease.Confirmed from 2017 state Pará were basis for this space-time study. The database Department Informatics Ministry Health was used access data on leptospirosis. analysis performed SaTScan software detection clusters, maps generated QGIS software.The municipalities Belém...
Human T-limphotropic virus 1 infection has a global distribution, with high prevalence in some regions of Brazil and the world, while HTLV-2 is endemic mainly among indigenous people drug users. To analyze intrafamilial transmission HTLV-1/2 five Kayapó peoples (Gorotire, Kararaô, Kokraimoro, Kubenkokre, Xikrin do Bacajá), we investigated 1452 individuals who underwent serological molecular tests. Among 276 positive results, identified intrafamily 42.7% cases, representing 38 families. It...
Chlamydia trachomatis is one of the most prevalent sexually transmitted bacteria worldwide and may increase risk other infections (STIs) including human immunodeficiency virus (HIV). This study describes seroprevalence C. infection among antiretroviral-naïve patients who are newly diagnosed with HIV in city Belém, Pará, Amazon region Brazil. A cross-sectional was carried out between January 2018 2019 141 people living HIV/AIDS (PLHA) were followed up a specialized unit public health network...
The polyomaviruses that infect humans, JC virus (JCV) and BK (BKV), can establish persistent infections in the cells make up renal system, causing nephritis BKV-associated nephropathy to 10% of transplant patients, these, 90% lose graft return for hemodialysis. This study aimed determine prevalence (PyV) population with chronic kidney disease (CKD), classified into three groups (conservative, dialysis, transplanted) a control group. Urine samples were collected from 290 individuals,...
Objetivo: Analisar a tendência temporal física e financeira dos procedimentos de hemodiálise no Pará. Métodos: Estudo ecológico análise séries temporais realizados em residentes do Pará, entre 2008 2017. Os dados foram coletados Sistema Informações Ambulatorial. Para da foi realizada regressão linear simples. Resultados: Verificou-se elevado número aprovados custos associados aos período estudado, com crescimento ascendente sessões todas as regiões saúde, sendo maior nas que possuem...
December 2019 saw several cases of pneumonia unknown origin reported in Wuhan, China; the cause this disease was later identified as new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The purpose present study to evaluate epidemiological profile (COVID-19) North Region Brazil assess possible correlations between demographic, social and health factors well adherence safety protocols COVID-19. Information obtained via a socio survey carried out using Google Forms shared on...
Abstract Background: The HIV-1 epidemic is still considered a global public health problem, but great advances have been made in fighting it by antiretroviral therapy (ART). ART has considerable impact on viral replication and host immunity. production of type I interferon (IFN) key to the innate immune response infections. STING cGAS proteins proven roles antiviral cascade. present study aimed evaluate immunity, which was represented gene expression plasma IFN-α level. Methods: This cohort...