Background HTLV-1 is a retrovirus that causes lymphoproliferative disorders and inflammatory degenerative diseases of the central nervous system in humans. The prevalence this infection high parts Brazil there general lack public health care programs. As consequence, official data on transmission routes virus are scarce. Objective To demonstrate familial aggregation HTLV infections metropolitan region Belém, Pará, Brazil. Method A cross-sectional study involving 85 carriers treated at an...

No presente estudo, foram avaliados comparativamente os níveis atuais de exposição ao mercúrio e as manifestações neurológicas em ribeirinhos residentes comunidades situadas no Estado do Pará, Brasil. Participaram estudo 78 Barreiras (bacia rio Tapajós), 30 São Luiz Tapajós Tapajós) 49 Furo Maracujá Tocantins). As concentrações total quantificadas, cabelo, pela espectrofotometria absorção atômica, a avaliação neurológica foi realizada por meio testes rotina. nas maiores que Tocantins (p <...

The spread of the HTLV infection in families living metropolitan area Belém, Pará, Brazil, and lack studies general population requires to better understand its prevalence region.An anti-HTLV-1/HTLV-2 antibodies test was carried out on random adults public places Belém between November 2014 2015. A proviral DNA detected if person infected, then a clinical evaluation an intrafamilial investigation were out.Of 1059 individuals being investigated, 21 (2.0%) had seroreagent samples, 15 (1.4%)...

INTRODUCTION: Viral hepatitis is a major public health concern in Brazil. There are few past studies on this issue, especially among riparian communities. This study aims at determining the seroprevalence of viral B and C community Pacuí Island, within Cametá municipality Pará State, Moreover, to investigate principal risk factors that exposed to. METHODS: The current has accessed blood samples from 181 volunteers who have answered an epidemiological questionnaire. Analyses serological...

The purpose of this work was to evaluate the somatosensory system methylmercury-exposed inhabitants living in communities Tapajós river basin by using psychophysical tests and compare with measurements performed Tocantins basin. We studied 108 subjects from Barreiras São Luiz do Tapajós, two basin, State Pará, Amazon, Brazil, aged 13–53 years old. Mercury analysis head hair samples weighting 0.1–0.2 g atomic absorption spectrometry. Three were performed: tactile sensation threshold,...

Human T lymphotropic virus 1 (HTLV-1) is a retrovirus associated with inflammatory diseases, including HTLV-1-associated myelopathy (HAM), and host genetic factors may be involved in disease evolution. The forkhead Box P3 (FOXP3) transcription factor linked to homeostasis of the immune system, presence polymorphisms promoter region FOXP3 gene should reflect its expression levels consequent activation regulatory cells, which contribute severe disorders, such as HAM. This study evaluated...

Introduction This study investigated the occurrence of Strongyloides stercoralis infestation and coinfection with HTLV-1/2 in Belém, Brazil. Methods S. was stool samples obtained from individuals infected their uninfected relatives. Results The frequency 9% (9/100), including six patients HTLV-1 (14.3%), two HTLV-2 (11.1%), one relative. Two cases hyperinfestation by were characterized as HTLV-1. Conclusions These results support need for routine investigation HTLV-1, an attempt to prevent...

Los virus linfotrópicos humanos de células T (HTLV) pertenecen a la familia Retroviridae, subfamilia Orthoretrovirinae y al género Deltaretrovirus.Evidencias epidemiológicas consistentes señalan HTLV-1 como agente asociado enfermedades como: Leucemia/ Linfoma Células del Adulto conocida LLTA o ATL, Paraparesia Espástica Tropical/ Mielopatía Asociada PET/MAH 1,2,3 TSP/HAM, uveítis dermatitis infectiva .Con relación HTLV-2, raramente se lo ha esas 4 .Y apenas entre 1% 4% los individuos...

Human T-lymphotropic virus type 1 (HTLV-1) deregulates the immune system and cell cycle, resulting in loss of tolerance disease, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three prime repair exonuclease (TREX1) maintains innate host host-cell permissiveness to retroviral infections. TREX1 polymorphisms may influence course infection autoimmune manifestations. The 531C/T polymorphism was investigated HTLV-1 development symptoms among 151 persons infected...

Os linfomas e outras doencas linfoproliferativas representam uma importante parcela dentre as causas de mortalidade populacional por neoplasias malignas no Brasil mundo. Este estudo descreveu o perfil epidemiologico dos portadores atendidos em um centro alta complexidade oncologia (CACON) Belem, Estado do Para. Foi realizada analise prontuarios pacientes CACON entre 2005 2011, maiores 15 anos idade, ambos os sexos com diagnostico linfoproliferativas, como linfoma Hodking (LH), nao (LNH)...

Abstract Background Human T-lymphotropic virus 1 (HTLV-1) is etiologically associated with the chronic inflammatory neurodegenerative disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) Annexin A1 (AnxA1) an anti-inflammatory protein proposed neuroprotective and anti-neuroinflammatory functions. We hypothesized that ANXA1 gene expression may be dysregulated in HTLV-1-infected HAM/TSP patients. Methods This study involved 37 individuals infected HTLV-1, including 21...

Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 were originally described as sporadic entities, family aggregations have reported. Viral, genetic, immunological behavioral factors used to explain clusters, until now clear explanation uncertain. In the present study we report, for first time, cluster of diseased persons presenting across three generations FAS -670A/G polymorphism.

SAMHD1, a host dNTPase, acts as retroviral restriction factor by degrading the pool of nucleotides available for initial reverse transcription retroviruses, including HTLV-1. Polymorphisms in SAMDH1 gene may alter enzymatic expression and influence course infection virus. The present study investigated effect polymorphisms on HTLV-1 susceptibility progression to disease 108 individuals infected (47 symptomatic 61 asymptomatic) 100 control group. SAMHD1 rs6029941 (G/A) genotyping proviral...

The hepatitis C virus has been recognized as the leading cause of chronic liver disease in world. Host genetic factors have implicated persistence infection. Single nucleotide polymorphisms at positions -607 C/A (rs1946518) and -137 G/C (rs187238) IL-18 gene promoter suggested to be associated with delayed clearance disease.Identify these a population infected from Brazilian Amazon region.In cross-sectional analytical study conducted Belém, Pará, Brazil, 304 patients were divided into two...

The human T-lymphotropic virus type 1 (HTLV-1) affects 2–5 million people worldwide, and is associated with a number of degenerative infectious diseases. Envelope glycoproteins (gp) are highly conserved among the different HTLV-1 isolates, although nucleotide substitutions in region that codifies these proteins may influence both infectivity replication virus. gp46 gene has functional domains which have been inhibition formation syncytium, cell-cell transmission, production antibodies....

<b><i>Introduction:</i></b> HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy associated with an inflammation of the central nervous system (CNS), being characterized by perivascular infiltration inflammatory cells. HTLV-1-infected cells have capacity to migrate through endothelial layers enhancing adhesion receptor expression and corresponding ligands. T interact extracellular matrix via integrin receptors these...

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence HCV genotypes and investigate influence these on disease progression. Methods: Blood samples biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, genotyping histopathological evaluation. Results: Hepatitis virus-ribonucleic acid (HCV-RNA) was detected in 107 (90.6% with genotype 1 9.4% 3)....

The human T-lymphotropic virus type 1 (HTLV-1), isolated in 1980, causes T-cell leukemia/lymphoma adulthood, a of lymphoproliferative disease, and chronic HTLV-1-associated myelopathy, disease that paralysis the lower limbs, which occur about 5% cases this viral infection. This study aimed to establish hematological profile patients with HTLV-1 infection Belém do Pará, describing parameters under study, estimating frequency lymphocytic atypical, associating diseases symptoms. Hematologic...

In this study, we aimed investigated the differential gene expression profiles of samples from uninfected individuals (control group) and study groups asymptomatic human T-lymphotropic virus 1 (HTLV-1) carriers patients with HTLV-1-associated myelopathy (HAM) by exploratory RNA sequencing (RNA-Seq) analysis. The in group were represented 3 genes, most associated cell cycle regulation. HAM 12 majority which are immune response. HLA-A non-coding LINC02470 upregulated groups. HLA-DQB1 HLA-C...

Introduction TLR7 detects the presence of single-stranded RNA (ssRNA) viruses, including human T-lymphotropic virus 1 (HTLV-1), and triggers antiviral inflammatory responses that are responsible for infection control. Genetic variations in gene may alter cytokine production influence course HTLV-1 infection. In present study, associations polymorphisms with HTLV-1-related symptoms, receptor expression levels, IFN-α TNF-α levels proviral load were investigated. Methods Blood samples from 159...

Genetic variations in components of the immune response seem to be an important factor that contributes manifestation symptoms some diseases related HTLV-1 infection. Nerve growth (NGF) and p75 neurotrophin receptor (p75NTR) are maintenance neurons activation response. In this study, we evaluated association NGF -198C/T, Ala35Val, p75NTR Ser205Leu polymorphisms with infection plasma cytokine levels 166 samples from individuals infected (59 symptomatic 107 asymptomatic). The genotyping...

OBJETIVOS: Descrever os resultados da investigação epidemiológica infecção pelo vírus linfotrópico-T humano (HTLV) e enfatizar a importância das ações de extensão universitária na prevenção dessa doenças associadas em Belém, estado do Pará, Brasil.

Abstract Introduction Individuals infected with the human T‐cell lymphotropic virus type 1 ( HTLV ‐1) commonly present skin lesions, which may be a warning sign for diagnosis of infection. This study describes most prevalent manifestations in carriers attended at clinic Núcleo de Medicina Tropical NMT ) Universidade Federal do Pará UFPA Belém, Pará, Brazil. Methods is series cases patients types and 2 ‐1/2) treated between 1999 2016. A descriptive analysis data was applied. Results Among 788...