A5103025883- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Stochastic Gradient Optimization Techniques
- Machine Learning and Algorithms
- Quantum Computing Algorithms and Architecture
- Liver physiology and pathology
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Liver Diseases and Immunity
- DNA and Nucleic Acid Chemistry
- Liver Disease and Transplantation
- Cryptography and Data Security
- Adenosine and Purinergic Signaling
- Diet, Metabolism, and Disease
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Neurofibromatosis and Schwannoma Cases
- Platelet Disorders and Treatments
- Streptococcal Infections and Treatments
- Nanoparticle-Based Drug Delivery
- Autoimmune Bullous Skin Diseases
- Neuroblastoma Research and Treatments
AstraZeneca (Sweden)
2025
Syngene International (India)
2017-2023
Biocon (India)
2017-2023
Bristol-Myers Squibb (India)
2017-2023
Ferring Pharmaceuticals (Denmark)
2023
Indraprastha Institute of Information Technology Delhi
2023
Bristol-Myers Squibb (United States)
2017-2022
KU Leuven
2013-2021
Uppsala University
2021
Vrije Universiteit Brussel
2021
Inside-out–oriented membrane vesicles are useful tools to investigate whether a compound can be an inhibitor of efflux transporters such as multidrug resistance–associated protein 2 (MRP2). However, because technical limitations substrate diffusion and low dynamic uptake windows for interacting drugs used in the clinic, estradiol-17<i>β</i>-glucuronide (E17<i>β</i>G) remains probe that is frequently MRP2 inhibition assays. Here we recapitulated sigmoidal kinetics MRP2-mediated transport...
Expression and functional changes in the organic anion transporting polypeptide (OATP)-multidrug resistance-associated protein (MRP) axis of transporters are well reported patients with nonalcoholic steatohepatitis (NASH). These can impact plasma tissue disposition endo- exogenous compounds. The transporter alterations often assessed by administration a xenobiotic or proteomic analysis from liver biopsies. Using gene expression, proteomics, endogenous biomarkers, we show that expression...
Drug-induced cholestasis (DIC) is a major cause of clinical failure drug candidates. Numerous patients worldwide are affected when exposed to marketed drugs exhibiting DIC signature. Prospective identification during early compound development remains challenging. Here we describe the optimized in vitro procedure for assessment and prediction an increased risk. Our method based on three principles:•Exposure primary human hepatocyte cultures test compounds absence presence physiologically...
Previously we reported that coproporphyrin-I (CP-I) is an optimal probe substrate for multidrug resistance-associated protein 2 (MRP2), and stimulation of MRP2-mediated transport substrate-dependent. In the present investigation, assessed if in vitro physiologically relevant. Similar to human MRP2 transport, CP-I was transported by rat Mrp2 a typical Michaelis-Menten kinetics with apparent Km Vmax values 15 ± 6 µM 161 20 pmol/min/mg protein, respectively. vivo functions were monitored...
Farnesoid X receptor (FXR) is a nuclear known to markedly alter expression of major transporters and enzymes in the liver. However, its effects toward organic anion transporting polypeptides (OATP) 1B1 1B3 remain poorly characterized. Therefore, present study was aimed at determining chenodeoxycholic acid (CDCA), naturally occurring FXR agonist, on OATP1B cynomolgus monkeys. Multiple administrations 50 100 mg/kg CDCA were first shown significantly repress mRNA <i>SLCO1B1/3</i> approximately...
Bosentan, a well–known cholestatic agent, was not identified as at concentrations up to 200 µM based on the drug-induced cholestasis (DIC) index value, determined in sandwich-cultured human hepatocyte (SCHH)–based DIC assay. To obtain further quantitative insights into effects of bosentan cellular bile salt handling by hepatocytes, present study effect 2.5–25 endogenous levels and disposition 10 chenodeoxycholic acid (CDCA) added medium SCHHs. Bosentan reduced intracellular well...
Coproporphyrins I and III (CP-I CP-III) are established as substrates of hepatic sinusoidal organic anion transporting polypeptides (Oatps), multidrug resistance-associated protein 3 (Mrp3), canalicular transporter Mrp2. We aimed to evaluate the potential plasma CP-I CP-III concentrations indicate functional changes in transporters nonalcoholic stea-tohepatitis (NASH) rodent models using modeling simulation approach. Mechanistic copro-porphyrins rats mice were constructed based on...
Aspirin (acetyl salicylic acid) is widely used co-medication in patients with cardiovascular and cerebrovascular diseases. Given the prevalence of acetyl acid’s use as a conflicting reports literature on it being substrate P-glycoprotein (P-gp). There potential risk for its interaction compounds P-gp liability, therefore, we have conducted detailed investigation to determine acid towards P-gp. We observed significantly lower cellular uptake MDR1 transfected LLC-PK1 cells compared wild-type...
Abstract Background: Neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (PN) can cause substantial morbidity by disfigurement and compression of vital structures. Real-world data on the burden cost disease among pediatric patients with NF1 PN is limited. The objectives this study were to describe characteristics, treatment patterns, healthcare resource use (HCRU), costs these patients. Results: A total 383 included in retrospective analysis aged ≤18 at least ICD-10-CM diagnosis...
Abstract Boosting is an ensemble learning method that converts a weak learner into strong in the PAC framework. The AdaBoost algorithm well-known classical boosting for learners with binary hypotheses. Recently, Arunachalam and Maity presented first quantum by quantizing AdaBoost. Their algorithm, which we refer to as QAdaBoost hereafter, adaptation of only works hypothesis case. quadratically faster than terms VC dimension class learner. However, polynomially worse bias In this work,...
In this work, we propose a novel architecture (and several variants thereof) based on quantum cryptographic primitives with provable privacy and security guarantees regarding membership inference attacks generative models. Our can be used top of any existing classical or We argue that the use gates associated unitary operators provides inherent advantages compared to standard Differential Privacy techniques for establishing guaranteed from all polynomial-time adversaries.