A5020515686- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- Ear and Head Tumors
- Tumors and Oncological Cases
- Head and Neck Cancer Studies
- Oral and gingival health research
- Oral health in cancer treatment
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders
- Cancer, Hypoxia, and Metabolism
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Salivary Gland Disorders and Functions
- Cancer Cells and Metastasis
- Head and Neck Surgical Oncology
- Oral and Craniofacial Lesions
- Teratomas and Epidermoid Cysts
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- HIV/AIDS oral health manifestations
- Vascular Tumors and Angiosarcomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
Universidade Estadual de Campinas (UNICAMP)
2019-2025
University of Michigan–Ann Arbor
2024
Tata Memorial Hospital
2022
University of California, San Francisco
2022
New York University
2022
Methodist University of Piracicaba
2019-2020
Hospital de Clínicas da Unicamp
2019
Forest Science and Research Institute
2019
Abstract Background 6‐Nitrodopamine (6‐ND) released from rat vas deferens acts an endogenous modulator of contractility. Objectives To investigate whether isolated seminal vesicles (RISV) releases 6‐ND, the mechanisms involved in release, and modulatory role 6‐ND on tissue Methods Rat were removed placed Krebs–Henseleit's solution at 37°C for 30 min, aliquot was used to analyze concentrations dopamine, noradrenaline, adrenaline by liquid chromatography with tandem mass spectrometry...
Establishing the risk of malignant transformation (MT) in oral leukoplakia is usually based on grading epithelial dysplasia (OED) biopsy tissue, for which two systems are proposed: a 3-tier and binary system. Only very few actuarial studies have tested accuracy such methods predicting MT, especially This study aimed to assess MT cohort (OL) from Brazil, with follow-up data.The sample comprised 878 individuals diagnosed OL 2005 2018. Follow-up data were obtained both locally regional cancer...
Abstract Objective This study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent (RPA), residual PA, and carcinoma ex (CXPA). Materials Methods We analyzed 13 4 RPA, 29 CXPA, 14 PA using Nexus Copy Number Discovery software. The miRNAs affected by CNAs were evaluated based on their expression patterns subjected pathway enrichment analysis. Results Across the groups, we found 216 affecting 2261...
To analyze the gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, adipophilin in normal salivary gland (NSG), pleomorphic adenoma (PA), carcinoma ex (CXPA) samples.The was investigated by real-time PCR (qRT-PCR) method 9 samples frozen tissues gland, 13 PA, 10 CXPA. We validated reactions immunohistochemistry on 20 from NSG, 85 44 CXPA.Our results showed that there no statistically significant difference HIF-1α among studied while FASN increased along carcinogenesis PA. GLUT-1...
The difficulty in risk assessing oral leukoplakia (OL) for malignant transformation has recently been reduced as novel strategies based on DNA content measurements have providing consistent and reproducible predictive values, with a major advantage of using archived material. Regrettably, most such approaches are costly equipment human resources that not widely available, especially populations limited access to dedicated technology. aim this study was investigate marker adapting image-based...
To analyze the proteomic profile of salivary pleomorphic adenoma (PA) and carcinoma ex (CXPA) samples correlate them with malignant transformation PA.
The mechanisms involved with the pathogenesis of carcinoma ex pleomorphic adenoma (CXPA) seem to be associated accumulation molecular alterations in (PA). In this sense, using array-based comparative genomic hybridization (aCGH) a rare series 27 cases CXPA and 14 residual PA (rPA) adjacent transformation area, we investigated profile copy number (CNAs) comparing benign transformed areas. main findings were correlated histopathological classification by histologic subtype degree invasion....
Adenoid cystic carcinoma (ACC) is a rare neoplasm known for its indolent clinical course, risk of perineural invasion, and late onset distant metastasis. Due to the scarcity samples tumor’s rarity, progress in developing effective treatments has been historically limited. To tackle this issue, high-throughput screening epigenetic drugs was conducted identify compounds capable disrupting invasive properties tumor cancer stem cells (CSCs). ACC were screened changes viability, chromatin...
Fatty acid synthase (FASN) expression is closely related to cancer progression, in particular, tumor aggressiveness and poor prognosis. This study aimed analyse the of FASN carcinomas salivary glands correlate it with Ki-67 expression. We analysed by immunohistochemistry Ki‐67 on tissue sections from 7 cases adenocarcinoma, not otherwise specified (AdNOS), 6 polymorphous adenocarcinoma (PAC), 16 acinic cell carcinoma (AcCC), 19 adenoid cystic (AdCC), 15 epithelial-myoepithelial (EMC); 10...