A5002164739- Essential Oils and Antimicrobial Activity
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Phytochemicals and Medicinal Plants
- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pharmacological Effects of Medicinal Plants
- Pharmacological Effects of Natural Compounds
- Coconut Research and Applications
- Medicinal Plants and Neuroprotection
- Phytochemical Studies and Bioactivities
- Wound Healing and Treatments
- Antibiotic Use and Resistance
- Biological Activity of Diterpenoids and Biflavonoids
- Natural Antidiabetic Agents Studies
- Nuclear Receptors and Signaling
- Chemotherapy-induced organ toxicity mitigation
- Planarian Biology and Electrostimulation
- Pharmacogenetics and Drug Metabolism
- PARP inhibition in cancer therapy
- Vitamin C and Antioxidants Research
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
Tanta University
2020-2025
Tanta University Hospital
2022
The acute inflammation process is explained by numerous hypotheses, including oxidative stress, enzyme stimulation, and the generation of pro-inflammatory cytokines. anti-inflammatory activity Yucca gigantea methanol extract (YGME) against carrageenan-induced possible underlying mechanisms was investigated. phytochemical profile, cytotoxic, antimicrobial activities were also explored. LC-MS/MS utilized to investigate chemical composition YGME, 29 compounds tentatively identified. In...
Owing to the disseminating resistance among pathogenic bacteria, especially Klebsiella pneumoniae, there is a high need for alternate compounds with antibacterial activity. Herein, lycopene was isolated from Lycopersicon esculentum L. Molecular docking approach employed explore binding affinity selected vital proteins of K. pneumoniae mechanisms being investigated. This proposed promising activity lycopene. However, pharmacological use hampered by its poor solubility and limited oral...
Monterey cypress (Cupressus macrocarpa) is a decorative plant; however, it possesses various pharmacological activities. Therefore, we explored the phytochemical profile of C. macrocarpa root methanol extract (CRME) for first time. Moreover, investigated its antidiarrheal (in vivo), antibacterial, and antibiofilm vitro) activities against Salmonella enterica clinical isolates. The LC-ESI-MS/MS analysis CRME detected presence 39 compounds, besides isolation 2,3,2″,3″-tetrahydro-4'-O-methyl...
Lung diseases such as asthma, chronic obstructive pulmonary diseases, and pneumonia are causing many global health problems. The COVID-19 pandemic has directed the scientific community's attention toward performing more research to explore novel therapeutic drugs for diseases. Herein, gas chromatography coupled with mass spectrometry tentatively identified 44 compounds in frankincense ethanol extract (FEE). We investigated antibacterial antibiofilm effects of FEE against Pseudomonas...
Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that causes various infections. The increasing resistance of MRSA to different antibiotics widely spreading; therefore, plant extracts may be novel therapeutic alternatives. phytochemical profiling Cupressus macrocarpa Hartw. ex Gordon leaves in vitro, and vivo, antimicrobial potential its against clinical isolates were explored. A tentative identification 49 compounds was performed the using LC-ESI-MS/MS;...
The rising prevalence of non-alcoholic fatty liver disease NAFLD has strained the healthcare system. Natural products could solve this problem, so current study focused on impact G. thunbergia Thunb. against ailment. LC-ESI-MS/MS revealed phytochemical profile methanol extract from Gardenia leaves (GME). Forty-eight compounds were tentatively identified, and stigmasterol, fucosterol, ursolic acid, rutin isolated. separation last three plant had not before been achieved. anti-NAFLD effect...
Abstract The world’s concern about smoking hazards, chronic obstructive pulmonary disease (COPD) and lung cancer was the motivation to investigate plants as a source of new drugs with protective effect. phytochemical profile Vitis vinifera L. var. King Ruby leaves methanol extract (VLME) tentatively recognized by liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS). Fifty-two forty-seven compounds were identified negative positive ESI modes, respectively....
Drug-induced liver injury (DILI) is the main cause of damage mediated by excretion toxic active drug metabolites. Omega-3 fatty acids and vitamin C have potent antioxidant, anti-inflammatory, antiapoptotic effects that could offer protection against oxidative stress damage. This study evaluated hepatoprotective effect omega-3 alone as well in a combined form methotrexate- (MTX-) induced acute mice. Male ICR mice seven groups (7 per group) were used. Groups 1 (control 2 (MTX) received 0.9%...
Owing to the spread of resistance between pathogenic bacteria, searching for novel compounds with antibacterial activity is essential. Here, we investigated potential Greek clover or Trigonella foenum-graecum herb extract on Salmonella typhimurium clinical isolates. The chemical profile was initially determined using LC-ESI-MS/MS, which explored 36 different compounds. Interestingly, fenugreek possessed action in vitro minimum inhibitory concentrations 64 512 µg/mL. mechanism studied by...
Neuroinflammation is a serious immunomodulatory complex disorder that causes neurological and somatic ailments. The treatment of brain inflammation with new drugs derived from natural sources significant therapeutic goal. Utilizing LC-ESI-MS/MS analysis, the active constituents Salvadora persica extract (SPE) were identified tentatively as exerting antioxidant anti-inflammatory effects in medicine. Herein, we determined antiviral potential SPE against herpes simplex virus type 2 (HSV-2)...
Context: It has been reported that Cupressus macrocarpa Hartw. ex Gordon (Cupressaceae) and Dioon edule Lindl. (Zamiaceae) contain compounds with antioxidant anti-inflammatory effects; therefore, they may exert a nephroprotective effect. Aims: To explore the renoprotective effect of C. D. underlying molecular mechanisms. Methods: Ten male Wister rats were used for each group control (1% CMC in saline), gentamicin (GM, 40 mg/kg), leaves methanol extract (DLM), combined petroleum ether (CLEM)...
Context: It was found that flavonoids and frankincense exert anti-cancer effect through their antioxidant anti-inflammatory activities. Aims: To evaluate the cytotoxic against MCF-7 cells of isolated from Physalis pubescens L., ethanol extract combined therapy with epirubicin to reduce resistance side effects. Methods: MTT assay carried out for rutin, quercitrin, myricitrin frankincense. The compound or best tested WI-38 cells. 50% inhibitory concentration (IC50) different treatments...
The increasing rates of morbidity and mortality owing to bacterial infections, particularly
Abstract Context: flavonoids have a pivotal cytotoxic effect against hepatocellular carcinoma (HCC). Aims To reveal which flavonoid isolated from Physalis pubescens L. leaves exerts the most HepG2 liver cancer cells and if it could ameliorate epirubicin efficacy safety through regulating apoptosis autophagy. Methods Baicalein trimethyl ether (BTE), rutin, quercitrin myricitrin were Pubescens leaves. treated with as well combination of BTE epirubicin. Cell viability was assessed by MTT assay...