A5046190581- melanin and skin pigmentation
- Epilepsy research and treatment
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects and Toxicity Studies
- Medicinal Plants and Neuroprotection
- Dermatologic Treatments and Research
- Phytochemistry and Biological Activities
- Wound Healing and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Biochemical Analysis and Sensing Techniques
- Skin Diseases and Diabetes
- Skin Protection and Aging
- Metabolomics and Mass Spectrometry Studies
- Leaf Properties and Growth Measurement
- Probiotics and Fermented Foods
- Andrographolide Research and Applications
- Agricultural Practices and Plant Genetics
- Concrete Properties and Behavior
- Phytochemistry and Bioactivity Studies
- Olfactory and Sensory Function Studies
- Allelopathy and phytotoxic interactions
- Plant tissue culture and regeneration
- Phytochemistry and biological activity of medicinal plants
- Bioactive Natural Diterpenoids Research
Cairo University
2016-2025
Tanta University
2023-2025
National University of Malaysia
2018-2024
Ain Shams University
2019-2023
University Kebangsaan Malaysia Medical Centre
2013
Atomic Energy Commission of Syria
2006
Universidad de Cantabria
1998
Tel Aviv Sourasky Medical Center
1998
University of Pavia
1998
Istanbul University
1998
New treatment modalities for vitiligo acting by changing certain cytokines and metalloproteinases are newly emerging. The aim of this work is to To assess the efficacy trichloroacetic acid (TCA) chemical peel, dermapen, fractional CO2 laser in stable non-segmental detect their effects on IL-17 MMP-9 levels. Thirty patients with were recruited a randomized controlled study. They randomly categorized into three equal groups. Group 1: TCA 2: dermapen machine, 3: Fractional laser. Skin biopsies...
Abstract Background Vitiligo is a pigmentary disorder associated with considerable psychological imbalance. Partial response to therapy and long duration for repigmentation are common. Meanwhile, camouflage may help through concealing vitiligo lesions improving patient confidence self‐esteem. Aim To assess the Dermatology Life Quality Index (DLQI) in patients, determine patients’ acceptance willingness utilize regularly impact of using as an adjuvant modality. Patients/Methods The study was...
Abstract Ulcerative colitis (UC) is an inflammatory condition of the intestine, resulting from increase in oxidative stress and pro-inflammatory mediators. In this study, extract endophytic bacterium Rhizobium aegyptiacum was prepared for first time using liquid chromatography-mass spectrometry (LC-MS). addition, also time, protective potential R. revealed vivo rat model UC. The animals were grouped into four categories: normal control (group I), II), acetic acid (AA)-induced UC III),...
Abstract One of the complication diabetes mellitus is chronic wounds. The healing wounds in diabetic patients retarded by elevation pro-inflammatory cytokines secretion and free radicles accumulation. Wound management requires preventing bacterial biofilm development. Due to wound activity chitosan (CS), lecithin (Le) melatonin (M), present study aimed load on CS/Le NPs examine their effect infected with Staphylococcus aureus . Melatonin loaded chitosan/lecithin nanoparticles (M-CS/Le NPs)...
Autoimmune and metabolic disturbances have been reported in association with vitiligo, highlighting possible systemic associations that should be considered.To assess the of syndrome (MetS) as well insulin resistance (IR) vitiligo different age groups.This case-control study included 142 patients aging ≥ 6 years age- sex-matched controls. Participants were assessed for MetS using International Diabetes Federation (IDF) criteria addition to IR via homeostasis model assessment (HOMA-IR). The...
Melasma is a hard-to-manage disorder with considerable relapsing behavior. Dermoscopy emerged to help in comprehensive evaluation of pigmentary disorders and melasma. The aim the study was evaluate potential role dermoscopy assessing melasma monitoring efficacy 1064-nm low-fluence Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) laser. A total 31 patients facial were included. five laser sessions performed 2-week intervals. Patients evaluated at baseline 2 weeks after last session...
Owing to the spread of resistance between pathogenic bacteria, searching for novel compounds with antibacterial activity is essential. Here, we investigated potential Greek clover or Trigonella foenum-graecum herb extract on Salmonella typhimurium clinical isolates. The chemical profile was initially determined using LC-ESI-MS/MS, which explored 36 different compounds. Interestingly, fenugreek possessed action in vitro minimum inhibitory concentrations 64 512 µg/mL. mechanism studied by...
Distinguishing vitiligo activity/stability status is pivotal in the management of patients with vitiligo. CXCL10 a chemokine released tissues and sera an indicator disease activity.This study aimed to assess role dermoscopy detecting active stable by comparing dermoscopic signs Vitiligo Disease Activity Score (VIDA), clinical activity, activity.Ninety-seven were enrolled this cross-sectional study. was assessed using VIDA scores, examination, dermoscopy, serum levels measured enzyme-linked...
Jasmonic acid (JA) and its derivative, methyl JA (MeJA) are hormonal cues released by plants that signal defense response to curb damages from biotic abiotic stresses. To study such response, a tropical herbal plant, Persicaria minor, which possesses pungent smell various bioactivities including antimicrobial anticancer, was treated with MeJA. Such elicitation has been performed in hairy root cultures as Arabidopsis rice, yet how MeJA influenced the proteome of an species like P. minor is...
Abstract Background Sugars and triglycerides are common carbon sources for microorganisms. Nonetheless, a systematic comparative interpretation of metabolic changes upon vegetable oil or glucose as sole source is still lacking. Selected fungi that can grow in acidic mineral salt media (MSM) with had been identified recently. Hence, this study aimed to investigate the overall metabolite an omnipotent fungus reveal at central metabolism corresponding both sources. Results Targeted non-targeted...
Kamalrul Azlan Azizana*, Sarah Ibrahima, Nurul Haizun Abdul Ghanib & Mohammad Firdaus Nawawiba Metabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia; b National Science Centre (PSN), Kuala Lumpur,
Abstract Background Among alopecia areata (AA) treatments, contact irritants (anthralin) and topical immunotherapies (diphenylcyclopropenone) have been successfully used. Chemoexfoliation can potentially be utilized, acting as consecutively immunomodulators. Peels via therapeutic wounding provoke growth factors cytokines that may induce hair regrowth. Aim To evaluate compare trichloroacetic acid (TCA) 35% phenol 88% peels effectiveness tolerability in patchy AA. Patients/Methods This...
The inflammatory reaction is induced by several factors like stimulation of different enzymes, oxidative stress, and production various proinflammatory mediators. Here, we elucidated the phytochemical profile Euphorbia milii ethanol extract (EMEE) then, studied its anti-inflammatory potential using a carrageenan-induced paw edema model in rats. It was found that average edoema weight substantially declined (p < 0.05) treatment with EMEE (100 mg/kg 200 mg/kg). Also, it noticed immunostaining...
Proteomics is often hindered by the lack of protein sequence database particularly for non-model species such as Persicaria minor herbs. An integrative approach called proteomics informed transcriptomics possible [1], in which translated transcriptome used database. In this current study, proteome profile were profiled using SWATH-MS technology complemented with documented profiling [2], first report tropical herb. The plant was also elicited a phytohormone, methyl jasmonate (MeJA) and...
In spite of multiple therapeutic regimens for vitiligo, disease relapse remains a challenge. Most guidelines consider systemic treatments only in rapidly progressive with wider surface areas. This delay halting the immune attack, may give chance further progression as well establishment resident memory T-cell population predisposing to future relapses. To assess ability early therapy localized (<2% BSA), recent onset (<6 months) vitiligo control activity and minimize possibility recurrence....
Serum leptin, an adipocytokine of interleukin-6 family, has been linked to vitiligo-associated metabolic derangements. Additionally, it proposed as inflammatory mediator with possible influence on vitiligo pathogenesis. This study aimed at assessing serum leptin in patients compared controls and whether different characteristics have levels.In this hospital-based, cross-sectional case-control study, 70 (35 segmental (SV) 35 Non-segmental (NSV)) age- sex-matched were assessed for...
Background: Phyllanthus amarus exhibited immunosuppressive and anti-inflammatory effects in several vitro vivo studies. However, there is no report on the inhibitory of its secondary metabolites pro-inflammatory cytokines secretion from human THP-1-derived macrophages. background: Objective: The objective this study was to correlate polyphenols (ellagic acid (EA), gallic (GA), geraniin (GER), corilagin (COR)) lignans ((phyllanthin (PHY), hypophyllanthin (HYPO), niranthin (NIR), phyltetralin...