A5078776291- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Gut microbiota and health
- Toxoplasma gondii Research Studies
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Microbial Metabolic Engineering and Bioproduction
- Nanoparticles: synthesis and applications
- Electrohydrodynamics and Fluid Dynamics
- Medicinal Plants and Neuroprotection
- Neurological Disorders and Treatments
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Plant responses to water stress
- Plant-Microbe Interactions and Immunity
- Phosphodiesterase function and regulation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neurological Disease Mechanisms and Treatments
- Plant Pathogenic Bacteria Studies
Tanta University
2020-2025
University of Mississippi
2020-2021
We aimed to synthesize zinc oxide nanoparticles (ZnO NPs) using the endophytic fungal extract of Aspergillus niger. The prepared ZnO NPs were characterized, and their in vitro vivo antibacterial activity was investigated. Isolated fungus identification carried out 18S rRNA. A. niger employed for green synthesis NPs. elucidated against Staphylococcus aureus broth microdilution method quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, a systemic infection model mice....
Abstract Ulcerative colitis (UC) is an inflammatory condition of the intestine, resulting from increase in oxidative stress and pro-inflammatory mediators. In this study, extract endophytic bacterium Rhizobium aegyptiacum was prepared for first time using liquid chromatography-mass spectrometry (LC-MS). addition, also time, protective potential R. revealed vivo rat model UC. The animals were grouped into four categories: normal control (group I), II), acetic acid (AA)-induced UC III),...
Respiratory tract infections are a common cause of morbidity and mortality globally. The current paper aims to treat this respiratory disorder. Therefore, we elucidated the phytochemical profile Euphorbia milii flowers isolated chlorogenic acid (CGA) for first time. electrospraying technique was utilized prepare CGA nanoparticles in polyvinyl alcohol (PVA)/PLGA polymeric matrix. Complete vitro characterizations were performed determine particle size, polydispersity index (PDI), zeta...
Various factors contribute to the development of acute inflammation process, like pro-inflammatory cytokines, certain enzymes as well oxidative stress mediators. The anti-inflammatory potential endophytic fungus Penicillium brefeldianum was explored in carrageenan-induced rats. After isolation from Acalypha hispida leaves, it identified by 18S rRNA gene sequencing. Then, its phytochemical profile elucidated using LC-ESI-MS/MS technique. There a remarkable decrease edema weight fungi-treated...
Emergent records propose that Aspergillus niger endophytic fungus is a vital source for various bioactive molecules possessing many biological properties. The current study was designed to inspect the antibacterial and anti-Toxoplasma potentials of Ficus retusa-derived fungi. After isolation identification (using 18S rRNA gene sequencing) A. fungus, LC/MS utilized authentication chemical profile endophyte extract. Then, fungal extract assessed its antibiofilm activities against Klebsiella...
Natural nitrogen heterocycles biotransformation has been extensively used to prepare synthetic drugs and explore the fate of therapeutic agents inside body. Herein, ability filamentous fungi biotransform boldine berberine was investigated. Docking simulation studies boldine, their metabolites on target enzymes: telomerase (TERT) human protein tyrosine phosphatase 1B (PTP-1B) were also performed investigate anticancer antidiabetic potentials compounds in silico. The with Cunninghamella...
The inflammatory reaction is induced by several factors like stimulation of different enzymes, oxidative stress, and production various proinflammatory mediators. Here, we elucidated the phytochemical profile Euphorbia milii ethanol extract (EMEE) then, studied its anti-inflammatory potential using a carrageenan-induced paw edema model in rats. It was found that average edoema weight substantially declined (p < 0.05) treatment with EMEE (100 mg/kg 200 mg/kg). Also, it noticed immunostaining...
Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites bioactive drugs used systemically. In this investigation, biotransformation natural alkaloid papaverine via filamentous fungi was explored. Molecular docking simulations, using protein tyrosine phosphatase 1B (PTP1B), α-glucosidase pancreatic lipase (PL) as target enzymes, were performed investigate antidiabetic potential its in silico. The isolated...