A5103070263- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune cells in cancer
- Diabetes and associated disorders
- Spinal Cord Injury Research
- Nuclear Receptors and Signaling
- melanin and skin pigmentation
- Diabetes Treatment and Management
Universitat de Barcelona
2024
Institut d'Investigació Biomédica de Bellvitge
2024
University of Campania "Luigi Vanvitelli"
2024
University of Cambridge
2020-2023
Managing postprandial blood glucose levels in children and adolescents with type 1 diabetes remains challenging, particularly high-carbohydrate meals. This study analyzed glycemic responses to Margherita pizza a ham sandwich similar macronutrient content using two different automated insulin delivery (AID) systems: MiniMed™ 780G Tandem t:slim X2™ Control-IQ. Thirty-four participants consumed both meals on separate occasions while maintaining standard boluses. Results showed no significant...
Traumatic spinal cord injuries (SCI) are a group of highly debilitating pathologies affecting thousands annually, and adversely quality life. Currently, no fully restorative therapies exist, SCI still results in significant personal, societal financial burdens. Inflammation plays major role the evolution SCI, with myeloid cells, including bone marrow derived macrophages (BMDMs) microglia (MG) being primary drivers both early secondary pathogenesis delayed wound healing events.The precise...
To investigate fear of hypoglycemia (FoH) in parents children with type 1 diabetes (T1D) before and after undergoing training to learn intranasal (IN) glucagon administration.
Abstract Innate immune responses following spinal cord injury (SCI) participate in early secondary pathogenesis and wound healing events. Here, we used time-resolved scRNAseq to map transcriptional profiles of SC tissue-resident infiltrating myeloid cells post-SCI. Our work identifies a novel subpopulation Fabp5 + inflammatory cells, comprising both resident displaying delayed cytotoxic profile at the lesion epicentre, which may serve as target for future therapeutics.
Abstract Parkinson’s disease (PD) is a progressive and yet incurable neurodegenerative condition characterized by loss of neuromelanin-containing dopamine neurons in the substantia nigra midbrain. The contribution non-neuronal cells to neuron degeneration PD receiving increasing attention. Here, we generated functional microglia-like from induced pluripotent stem (iPSC) patients with associated LRRK2 mutations, most common cause genetic PD, along their gene-corrected isogenic controls iPSC...
Hybrid closed loop systems (HCL) improve the management of type 1 diabetes (T1DM). T1DM adolescent patients represent a risk category also if they are in an automated insulin infusion delivery therapy.We describe series four cases which have adopted incorrect behaviours managing HCL systems, challenging algorithm skills. Two performed fabricated sensor calibrations. The other two did not perform pre-prandial boluses correctly. Despite these behaviours, corrected glucose values three out...