High doses of anabolic-androgenic steroids (AAS) are used by some athletes to increase muscle mass, that is often associated with male infertility. The aim this study was investigate the possible cause/s infertility using a rat model analysing sperm quality, including its protamine content and DNA integrity, as well pregnancy rate. Five groups Wistar rats were treated for 10 weeks follows: nandrolone decanoate (10 mg kg(-1) per week) (ND); running exercise (50 min day, 5 days (EX);...

Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease. The present study performed to assess the therapeutic role cannabidiol (CBD) against gentamicin-induced renal damage.Forty two male Wistar rats were randomly allocated into 6 groups (n=7), including: (1) Control, (2) Vehicle, (3) Gentamicin-treated group (100 mg/kg/day) for 10 days (GM), (4-6) 3 Gentamicin-CBD-treated (2.5, 5, and (GM+CBD2.5, GM+CBD5, GM+CBD10). Serum levels BUN Cr, histology well...

The aim of this study was to investigate the early changes cardiac uncoupling protein-2 (UCP2) expression following myocardial ischemia reperfusion in rats chronically treated with ramiprilat and losartan.Male Wistar were assigned into seven groups (six each): intact (control); sham-operated; nontreated subjected (IR); ramiprilat-treated (Ram+IR) without (Ram); losartan (Los+IR) (Los). Quantitative evaluation UCP2 mRNA carried out using real-time reverse transcription-polymerase chain...

This study investigated the effect of a selective A(1)-adenosine receptor (A(1)-AR) antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), on renal dysfunction and histological damage induced by ischaemia/reperfusion at an early stage.Pentobarbital anaesthetised rats were prepared for measuring functional variables. Ischaemia was bilateral artery clamping 30 min followed 4 h reperfusion period. In DPCPX-treated rats, it infused (i.v.) 10 microg/kg per before after ischaemia. Both kidneys...

Farnesoid-X-activated receptors (FXR) are key modulators of liver regeneration. Milk thistle and Chicory known as potent protective remedies in several disorders. The objective this work was to examine the role FXR hepato-healing properties milk (MTE) chicory extracts (CE) a rat model acetaminophen-induced hepatotoxicity.Male Wistar rats were randomly divided into seven groups including control, vehicle, acetaminophen (500 mg/kg/day, oral), plus oral MTE 200 400 CE 500 1000 /kg/day for 28...

Hypothesis/introduction: Our aim was to investigate whether a non-hypotensive dose of ramiprilat and losartan has myocardial protective effects during ischemia/reperfusion in vivo. Materials methods: Three groups rats were given 10 mg/kg per day for one (L-1W), four (L-4W) or (L-10W) weeks. Another three 50 µg/kg (R-1W), (R-4W) (R-10W) The animals underwent 30 min left anterior descending artery occlusion subsequent reperfusion 120 min. Results: Myocardial infarct size (IS) reduced R-1W...

Abstract Objectives In the present study, we aimed to determine whether intraperitoneal injection of platelet‐rich plasma (PRP) could have a neuroprotective effect on learning, memory, and synaptic plasticity impairment as well hippocampal apoptosis in rats with hepatic encephalopathy induced by bile duct ligated (BDL). Methods The were divided into four groups: control, sham, BDL+ V (vehicle), PRP. BDL treated PRP immediately after surgery, was done every 3 days for 30 days. passive...

Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs' effectiveness. This study was aimed compare antihypertensive vascular modifying activities of liposomal non-liposomal forms ascorbic acid.Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypertensive (HTN), (HTN-Veh), two Ascorbic acid-treated at 50 or 100 mg/kg/day (LVC-50 LVC-100), (VC-50 VC-100). Systolic blood pressure (SBP)...

ATP-sensitive potassium channels are supposed to have a substantial role in improvement of cardiac performance. This study was performed evaluate whether nandrolone decanoate (ND) and (or) exercise training could affect the expression K(ATP) channel subunits. Thirty-five male albino Wistar rats were randomly divided into 5 groups, including sedentary control (SC), vehicle (SV), ND (SND), (EC), (E+ND). Exercise on treadmill times per week. injected (10 mg/kg/week, i.m.) SND E+ND groups....

Prevalence of Acute Intoxication in Children Visiting Shahid Bahonar Hospital Karaj, Iran, 2014-2015

This study aimed to evaluate the relationship between Farnesoid-X-activated receptors (FXR) as nuclear regulators of antioxidant defense system well cardiac mitochondrial carrier proteins UCP2 and UCP3 in damage induced by cirrhosis.Twenty-two male Wistar rats (200-250 g) were randomly divided into 3 experimental groups, including a control group (n=6), sham-operated (n=8), bile duct ligated (BDL) (n=8). Four weeks after surgical intervention, biochemical assessment (AST, ALT, GGT, LDH,...

Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic patients. Studies have confirmed the protective effects of silymarin different types injury. This study aimed to examine effectiveness and molecular mechanism against myocardial hypertrophy rat model cirrhosis.The experiment was performed at Alborz University Medical Sciences (Karaj, Iran) during 2020-2021. Thirty-two male Wistar rats were randomly divided into four groups Sham-operated (control group for surgical...

Abstract Purpose The purpose is to determine the most effective machine learning method for identifying pathological grades of pancreatic neuroendocrine tumors (PNETs). This will be achieved by analyzing contrast-enhanced computed tomography scans both arterial and portal phases. investigation aims provide clinicians with an efficient reliable tool accurately PNETs grades. Materials Methods An was conducted on a cohort 100 patients diagnosed tumors. Definitive diagnoses grading results were...

Valproic acid (VA) is a broad-spectrum anticonvulsant agent that acts through several molecular mechanisms to control different types of seizures. The main concern the drug its liver toxicity. Considering regulatory roles Farnesoid nuclear receptors and transcription factor Nrf2 in modifying neutralizing harmful effects oxidative damage, present study was designed evaluate role FXR-Nrf2 some downstream target gene alterations hepatotoxicity induced by VA. Thirty-five eight-week-old male...

Alzheimer's disease is a neurodegenerative characterized by the accumulation of two different proteins, β-amyloid and tau. The present study aimed to scrutinize effects bilateral administration cannabinoid receptor antagonist (AM251) in hippocampus on spatial memory tau gene expression an model. toxin was injected bilaterally into Wistar male rats induce disease, were then categorized control group (receiving distilled water as solvent), lesion toxin), + DMSO (as solvent AM251), AM251...