A5015904772- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Pregnancy and preeclampsia studies
- Cancer Treatment and Pharmacology
- Maternal Mental Health During Pregnancy and Postpartum
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Preterm Birth and Chorioamnionitis
- Colorectal and Anal Carcinomas
- COVID-19 and healthcare impacts
- Fatty Acid Research and Health
- Emergency and Acute Care Studies
- Genetic factors in colorectal cancer
- Antibiotics Pharmacokinetics and Efficacy
- Child and Adolescent Health
- Cutaneous Melanoma Detection and Management
- Ethics and Legal Issues in Pediatric Healthcare
- Respiratory Support and Mechanisms
- Family and Patient Care in Intensive Care Units
- Reproductive System and Pregnancy
Kaiser Permanente
1990-2024
Colorado Permanente Medical Group
2023
Kaiser Foundation Hospital
2015-2022
Panorama Research (United States)
2021
Kaiser Permanente Fontana Medical Center
2020
Medizinische Hochschule Hannover
2019
University of Miami
2018
Riemser Pharma (Germany)
2005
Woodland Hills Medical Center
1990-2000
Johns Hopkins Hospital
1991
<h3>Importance</h3> There are few population-based studies addressing trends in neonatal intensive care unit (NICU) admission and NICU patient-days, especially the subpopulation that, by gestational age (GA) birth weight (BW), might otherwise be able to stay room with their mothers. <h3>Objective</h3> To describe admissions, readmissions, mortality population of a large integrated health system. <h3>Design, Setting, Participants</h3> This cohort study was conducted using data extracted from...
Most neonates admitted to a neonatal intensive care unit (NICU) are born at gestational age (GA) of 34 weeks or more. The degree uniformity admission criteria for these infants is unclear, particularly the low-acuity end range conditions warranting admission.To describe variation in NICU rates GA more and examine whether such associated with high illness acuity designated facility level care.Cross-sectional study 35 921 inborn admissions during calendar year 2015, using population database...
Objective The coronavirus disease 2019 (COVID-19) pandemic has created a need for data regarding the prevalence of severe acute respiratory syndrome 2 (SARS-CoV-2) infection in pregnant women. After implementing universal screening COVID-19 women admitted delivery, we sought to describe characteristics this large cohort Study Design An observational study labor and delivery units Kaiser Permanente Southern California (KPSC) hospitals between April 6 May 11, 2020 who were universally offered...
The use of intrapartum antibiotics to prevent early-onset group B streptococcal (EOGBS) infection has left pediatricians in a quandary about the appropriate evaluation and treatment infants at risk for this infection. aim study was determine whether antibiotic prophylaxis changed constellation timing onset clinical signs (GBS) term infants.We conducted retrospective chart review who had EOGBS were born Southern California Kaiser Permanente Hospitals from 1988 through 1996. Objective criteria...
<b>Objective</b> The risk of infection in infants mothers with chorioamnionitis (CAM) may be lower than previously reported. This study's objective was to determine the incidence intrapartum fever (IPF) and culture-positive early-onset bacterial neonatal (CPEOI) late preterm term or without CAM assess interhospital variation management. <b>Study Design</b> retrospective cohort study included newborns delivered at ≥35 weeks gestation Kaiser Permanente Southern California Hospitals 2010...
Although neonatal intensive unit (NICU) care is envisioned as the of very immature infants, more than 95% births and 80% NICU admissions are mature newborns—infants born at 34 or weeks' gestation. In spite size this population there important gaps in understanding their needs optimal management reflected by remarkably large unexplained variation care. The goal article to describe what known about mature, higher birth weight newborn population's use highlight knowledge obstacles research....
Seventy-seven previously untreated patients with measurable metastatic colorectal carcinoma were treated a combination of methyl-CCNU, 5-fluorouracil (5-FU), vincristine and streptozotocin (MOF-Strep). The treatment schedule consisted 30 mg/m2 for 5 consecutive days q 10 weeks; 5-FU, 300 IV five vincristine, 1 mg streptozotocin, 500 weekly. Two (3%) achieved complete remission (CR); 22 (29%) patients, partial (PR); 13 (18%) minor (MR). median duration was eight months (range, 4–25+months)...
Bronchopulmonary dysplasia (BPD) rates in the United States remain high and have changed little last decade.To develop a consistent BPD prevention bundle systematic approach to decrease BPD.This quality improvement study included 484 infants with birth weights from 501 1500 g admitted level 3 neonatal intensive care unit Kaiser Permanente Southern California system 2009 through 2019. The period was divided into periods: 1, baseline (2009); 2, initial changes based on ongoing cycles of...
Sixty-seven patients with measurable colorectal carcinoma were randomized to receive two different schedules of Methyl CCNU, 5-FU and Vincristine (MOF). The treatment schedule consisted CCNU 150 mg/m2 po q 70 days, 300 iv for 5 consecutive days 35 1 IV days. same total dose was used in each arm; MOF A, the given on day 1, while B, divided over In there a 10% partial response rate minor rate. 12% 21%. This difference is not statistically significant, but B experienced less gastrointestinal...
A prospective randomized trial evaluated semustine (Methyl CCNU) 5-Fluorouracil (5-FU) and vincristine (MOF) versus MOF plus streptozotocin (MOF-Strep) in 75 patients with advanced, measurable colorectal carcinoma. The complete partial remission rate MOF-Strep was significantly better, 34 5% (P = 0.003). Gastrointestinal toxicity increased the addition of streptozotocin. Initial patient characteristics such as age, sex, performance status, time from diagnosis to metastatic disease, site most...
BACKGROUND: The Antimicrobial Use (AU) Option of the Centers for Disease Control and Prevention’s National Healthcare Safety Network (NHSN) is a surveillance resource that can provide actionable data antibiotic stewardship programs. Such are used to enable measurements AU across hospitals before, during, after interventions. METHODS: We monthly annual facility survey submitted NHSN describe neonatal patient care locations reporting in 2017, examine frequencies most commonly reported agents,...
Objective This study aimed to examine whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy is associated with increased odds of perinatal complications and viral transmission the infant. Study Design A retrospective cohort women who delivered at Kaiser Permanente Southern California hospitals (April 6, 2020–February 28, 2021) was performed using data extracted from electronic health records (EHRs). During this time polymerize chain reaction...
Normothermia (36.5°C-37. 5°C) at the time of admission to neonatal intensive care unit (NICU) in extremely low birthweight (ELBW) infants (birth weight <1000 g) is associated with decreased morbidity and mortality, length stay hospital costs. We designed a thermoregulation bundle decrease hypothermia (<36.5°C) ELBW multidisciplinary perinatal quality improvement initiative that included following key interventions: dedicated delivery room (DR)/operating (OR) for all preterm deliveries...
Abstract HLA typing of amniotic fluid cells has been used for the prenatal diagnosis linked diseases congenital adrenal hyperplasia (21‐OH‐deficiency (21‐OH‐def) type) and complement C4 deficiency it also de termination paternity. There are, however, technical difficulties in this test associated with weak expression some B locus antigens on cells, theoretical related to associations between particular 21‐OH‐def allele. Since certain HLA‐B are found significantly increased frequencies among...
The HLA genotypes of members 104 families patients with acute myelogeneous leukemia (AML), 89 lymphocytic (ALL), and 40 control were analyzed. results indicate that the genotype both ALL AML leukemic is found more frequently than expected 25% among their siblings; increase for statistically significant. This suggests an HLA-linked factor(s) conferring susceptibility to may also be associated increased gametic survival. chance finding HLA-matched sibling bone marrow transplantation increased.
The microbiologic etiologies, clinical manifestations, and antimicrobial treatment of neonatal infections differ substantially from in adult pediatric patient populations. In 2019, the Centers for Disease Control Prevention developed neonatal-specific (Standardized Antimicrobial Administration Ratios SAARs), a set risk-adjusted use metrics that hospitals participating National Healthcare Safety Network's (NHSN's) surveillance can their antibiotic stewardship programs (ASPs).The Prevention,...
<h3>Importance</h3> Birth at hospitals with an appropriate level of neonatal intensive care units is associated better outcomes. The primary sources for information about hospital unit levels prospective parents, referring physicians, and the public are websites, but accuracy capacity unclear. <h3>Objective</h3> To determine if websites accurately report capabilities intermediate (ie, II) units, which intended newborns low to moderate illness or stabilization prior transfer. <h3>Design,...
To study the association between discontinuing predischarge car seat tolerance screening (CSTS) with 30-day postdischarge adverse outcomes in infants born preterm.Retrospective cohort involving all preterm from 2010 through 2021 who survived to discharge home a 14-hospital integrated health care system. The exposure was discontinuation of CSTS. primary outcome composite rate death, 911 call-triggered transports, or readmissions associated diagnostic codes respiratory disorders, apnea,...