A5048632398- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Medicinal Plant Extracts Effects
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Alkaloids: synthesis and pharmacology
- Morinda citrifolia extract uses
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemical Studies and Bioactivities
- Traditional Chinese Medicine Analysis
- Tryptophan and brain disorders
- Plant chemical constituents analysis
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Fungal Biology and Applications
- Cholinesterase and Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Chemical synthesis and alkaloids
- Hormonal Regulation and Hypertension
- Rheumatoid Arthritis Research and Therapies
Mexican Social Security Institute
2014-2024
Hospital Médica Sur
2021
Instituto Politécnico Nacional
2020
Instituto de Física del Sur
2019
Centro Científico Tecnológico Mar del Plata
2014
Universidad Autónoma del Estado de Morelos
2006-2008
Universidad Autónoma Metropolitana
2008
Istituto di Farmacologia Traslazionale
1998-2007
Universidad Nacional Autónoma de México
1997
Alzheimer's disease (AD) is a neuropathology strongly associated with the activation of inflammatory pathways. Accordingly, inflammation resulting from obesity exacerbates learning and memory deficits in humans animal models AD. Consequently, long-term use non-steroidal anti-inflammatory agents diminishes risk for developing AD, but side effects produced by these drugs limit their prophylactic use. Thus, plants natural products have become an excellent option modern therapeutics. Malva...
The anti-inflammatory activity of hexane (TlH) and acetone (TlAc) extracts from the aerial parts Tagetes lucida were evaluated in a mice model 12-Ο-Tetradecanoylphorbol 13-Acetate (TPA)-induced auricular oedema. Also, five coumarin compounds TlH extract identified, characterized evaluated: 7-isoprenyloxycoumarin (1), herniarin (2), 6-methoxy-7-isoprenyloxycoumarin (3), 6,7,8-trimethoxycoumarin (4) scoparone (5). Compounds 1 3 had not been previously identified T. lucida. Compound showed...
There are two major global morbidity and mortality problems in the health sector: inflammation, which is physiological process that, acute chronic conditions, gradually causes loss of body’s functionality, leading to severe damage health; microbial diseases, caused by pathogenic microorganisms such as bacteria. In present study, anti-inflammatory effects three extracts mesquite (Prosopis laevigata)—n-hexane (PH), dichloromethane (PD), methanol (PM)—were assessed a mouse model...
The metabolic syndrome (MS) is a condition consisting of various abnormalities that are risk factors for developing kidney failure, cardiovascular, vascular and cerebrovascular diseases, among others. prevalence this shows marked increase. aim study was to investigate the pharmacological effect Smilax aristolochiifolia root on some components MS obtain active principle using chromatographic techniques. compound isolated N-trans-feruloyl tyramine NTF (1), its structure determined by...
Species of the agave genus, such as Agave tequilana, angustifolia and americana are used in Mexican traditional medicine to treat inflammation-associated conditions. These plants’ leaves contain saponin compounds which show anti-inflammatory properties different models. The goal this investigation was evaluate capacity these plants, identify is most active, isolate active compound by a bio-directed fractionation using ear edema induced mice with 12-O-tetradecanoylphorbol-13-acetate (TPA)...
Recent studies of <i>Hibiscus sabdariffa</i> Linn. have demonstrated that it presents diuretic, natriuretic, and potassium sparing effects. However, the mechanism induces these effects has not yet been elucidated. The aim this study was to explore possible action for diuretic effect extract its fractions. aqueous from plant fractions obtained with solvents different polarities were administered adrenalectomized rats, measured in presence deoxycorticosterone acetate (aldosterone analog). on...
The aim of this study was to identify an anti-inflammatory compound from D. viscosa leaves. structure bioactive substance elucidated by IR and NMR studies, which indicated that natural product corresponds hautriwaic acid (HA). This diterpene exhibited good activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models applications at doses 0.25, 0.5 1.0 mg/ear (60.2, 70.2 87.1% inhibition, respectively); additionally Dodonaea dichloro-methane extract (DvDE) displays a 97.8%...
Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. The purpose of this work evaluate the antihypertensive effect hydroalcoholic extract obtained from roots plant, including its fractions subfractions, on different hypertension models induced with angiotensin II (AG II). was tested an vitro study isolated aorta rings denuded endothelial cells, using AG agonist; assay proved vasorelaxant extract. Vagotomized rats...
A series of nine nitro group-containing chalcones were synthesized to investigate their anti-inflammatory and vasorelaxant activities via in vivo, ex silico studies. The effects the compounds evaluated a TPA-induced mouse ear edema model, an isolated organ model addition molecular docking with highest activity 2 (71.17 ± 1.66%), 5 (80.77 2.82%), 9 (61.08 2.06%), where group is located at ortho position both rings, as confirmed by COX-1 COX-2. 1 (81.16 7.55%), lacking group, 7 (81.94 2.50%),...
In Mexico Agave angustifolia has traditionally been used to treat inflammation. The aim of this study was measure the anti-inflammatory effect extract A. angustifolia, isolation and identification active compounds. From acetone two fractions were obtained, (AsF13 AaF16). For characterization pharmacological activity, acute inflammatory model mouse ear edema induced with TPA used. tissue exposed treatments subjected analysis, cytokine quantification (IL-1β, IL-6, IL-10 TNF-α)...
An oligosaccharide fraction isolated from the mycelium of Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure GLOS consists a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)-1-]n (n=3,4). In addition, this study undertaken to determine possible anticonvulsant and neuroprotective effects (10-80 mg/kg) on kainic acid (KA)-induced seizures. behavioral alterations histopathology hippocampal neurons were...
Hypertension is a disease of high prevalence and morbidity where vascular inflammation associated oxidative stress (endothelial dysfunction) the underlying cause this pathology. We are reporting antihypertensive activity extracts fractions Malva parviflora in mice with chronic acute hypertension. Also, treatments plant were able to counteract kidney stress. The hypertension model consisted administration angiotensin II (AGII) during 12 weeks, causing sustained increase systolic (SBP) or...
<i>Sphaeralcea angustifolia</i>, an endangered plant species in Mexico, is employed to treat inflammatory processes and as a wound healing remedy. Scopoletin (1) was reported one of the main bioactive compounds this plant. Here, we isolated identified with anti-inflammatory properties from suspension-cultured cells <i>S. angustifolia</i>. The CH<sub>2</sub>Cl<sub>2</sub> : CH<sub>3</sub>OH extract exhibited acute inflammation models. Two were isolated, 5-hydroxy-6,7-dimethoxycoumarin, named...