A5013055764- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Venomous Animal Envenomation and Studies
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Organometallic Complex Synthesis and Catalysis
- Nicotinic Acetylcholine Receptors Study
- Molecular spectroscopy and chirality
- Proteoglycans and glycosaminoglycans research
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Supramolecular Chemistry and Complexes
- Advanced NMR Techniques and Applications
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Catalytic Cross-Coupling Reactions
- RNA Research and Splicing
- Metal complexes synthesis and properties
- Fluorine in Organic Chemistry
- Phytochemical compounds biological activities
- Synthesis and characterization of novel inorganic/organometallic compounds
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Chemical Reaction Mechanisms
Universidad Nacional Autónoma de México
2015-2024
University of California, Irvine
2011
Harvard University
1999-2007
University of Sheffield
1997
University of Cambridge
1994
Bridge University
1994
Eukaryotic initiation factor (eIF) 1 is a small protein (12 kDa) governing fidelity in translation initiation. It recruited to the 40 S subunit multifactor complex with Met-tRNA(i)(Met), eIF2, eIF3, and eIF5 binds near P-site. eIF1 release response start codon recognition an important signal produce 80 complex. Although ribosome-binding face of was identified, interfaces other preinitiation components their relevance function have not been determined. Exploiting solution structure yeast...
Animal venoms are rich sources of ligands for studying ion channels and other pharmacological targets. Proteomic analyses the soluble venom from Mexican scorpion Vaejovis mexicanus smithi showed that it contains more than 200 different components. Among them, a 36-residue peptide with molecular mass 3864 Da (named Vm24) was shown to be potent blocker Kv1.3 human lymphocytes (Kd ∼ 3 pM). The three-dimensional solution structure Vm24 determined by nuclear magnetic resonance, showing folds into...
Late embryogenesis abundant (LEA) proteins are part of a large protein family that protect other from aggregation due to desiccation or osmotic stresses. Recently, the Amarantus cruentus seed proteome was characterized by 2D-PAGE and one highly accumulated spot identified as Embryogenesis Abundant named AcLEA. In this work, AcLEA cDNA cloned into an expression vector recombinant purified characterized. encodes 172 amino acid polypeptide with predicted molecular mass 18.34 kDa estimated pI...
An oligosaccharide fraction isolated from the mycelium of Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure GLOS consists a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)-1-]n (n=3,4). In addition, this study undertaken to determine possible anticonvulsant and neuroprotective effects (10-80 mg/kg) on kainic acid (KA)-induced seizures. behavioral alterations histopathology hippocampal neurons were...
Abstract Long‐range 13 C,H NMR coupling constants were measured in strychnine at 400 MHz by a method that employs selective excitation of individual C sites under decoupled conditions followed polarization transfer to protons. The sensitivity was improved performing eight simultaneous soft‐pulse experiments coded (±) according Hadamard matrix and later separated reference the same matrix. antiphase splittings J ‐doubling performed frequency domain.
Wheat germ agglutinin (WGA) demonstrates potential as an oral delivery agent owing to its selective binding carbohydrates and capacity traverse biological membranes. In this study, we employed differential scanning calorimetry molecular dynamics simulations comprehensively characterize the thermal unfolding process of both complete lectin four isolated domains. Furthermore, present nuclear magnetic resonance structures three domains that were previously lacking experimental in their forms....
A new malbrancheamide analogue, isomalbrancheamide B (3), along with three known compounds, (1), (2), and premalbrancheamide (4), were isolated in higher yields from the alkaloid fraction of fungus Malbranchea aurantiaca. The interaction alkaloids 1–4 calmodulin (CaM) was analyzed using different enzymatic, fluorescence, spectroscopic, nuclear magnetic resonance (NMR), molecular modelling techniques. On basis enzymatic fluorescence experiments, malbrancheamides 1–3 are classical CaM...
The reactions of [M(PEt3)3] (M = Pt (1), Pd (2), Ni (3)) with 3-chlorothiophene, 2-chlorothiophene, 3-nitrothiophene, 2-nitrothiophene, 2-methoxythiophene, 3-methoxythiophene, 2-acetylthiophene, and 3-acetylthiophene afforded thiaplatinacycles the type [(Et3P)2M(C,S-C4H3RS)], (for M Pt, R Cl (4 5), NO2 (6 7), MeO (8 9), Ac (10 11); for Pd, (12 13), (14), (15 16), (17 18), Ni, (19)). When 3 2-chlorothiophene were reacted, another compound resulting from oxidative addition C−Cl bond could be...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Studies on Mexican Plants Used in Traditional Medicine, XVIII. New Secondary Metabolites from Dodonaea viscosaRachel Mata, José Luis Contreras, Daniel Crisanto, Rogelio Pereda-Miranda, Perla Castañeda, and Federico Del RioCite this: J. Nat. Prod. 1991, 54, 3, 913–917Publication Date (Print):May 1, 1991Publication History Published online1 July 2004Published inissue 1 May...
Reaction of the thiaplatinacyle [(Et3P)2Pt(C12H8S-C,S)] (3; derived from reaction [Pt(Et3P)3] and dibenzothiophene (DBT)) with HCl gives largely 2-phenylthiophenol a small amount DBT. The thiaplatinacycle [(Et3P)2Pt(C8H6S-C,S)] (2; benzothiophene (BT)) undergoes to give 2,3-dihydrobenzothiophene (22%), 2-vinylthiophenol, BT, while [(Et3P)2Pt(C4H4S-C,S)] (1; thiophene) regenerates thiophene HCl; in each case metal is found as [(Et3P)2PtCl2]. In contrast all thiaplatinacycles react very...
The reaction products of 1-trifluoromethanesulfonylpyridinium trifluoromethanesulfonate (TPT) with secondary amines have been thoroughly examined by spectroscopic and X-ray diffraction methods. include the normal ones expected for a ring-opening (1-azahexatriene cyanine) in addition to "unexpected"formation 4-substituted 1, 4-dihydropyridine. Tandem reactions -ring-opening, nucleophilic addition- on pyridinium ring seems be most probable pathway 4-dihydropyridine compounds. Preliminary tests...
(1)H NMR scalar coupling constants are a rich source of information on molecular structure, but their extraction from spectra can be less than straightforward. Previous approaches to J include methods proposed by Hoye, Golotvin, and the 'modified J-doubling' method. Here we describe ACCA method, currently implemented in package MestReC, which allows high degree automation patterns even case complex multiplets with sublinewidth splitting. The new approach is illustrated application...
Peptide-based therapy against cancer is a field of great interest for biomedical developments. Since it was shown that SK3 channels promote cell migration and metastatic development, we started using these as targets the development antimetastatic drugs. Particularly, tamapin (a peptide found in venom scorpion Mesobuthus tamulus) most specific toxin SK2 channel currently known. Considering this fact, designed diverse mutants based on three different hypotheses to discover new potent molecule...
Development of C-N coupling methodologies based on Earth-abundant metals is a promising strategy in homogeneous catalysis for sustainable processes. However, such systems suffer from deactivation and low catalytic activity. We here report that encapsulation Cu(I) within the phenanthroyl-containing calix[8]arene derivative 1,5-(2,9-dimethyl-1,10-phenanthroyl)-2,3,4,6,7,8-hexamethyl-p-tert-butylcalix[8]arene (C8PhenMe6 ) significantly enhances activity up to 92 % yield reaction aryl halides...