A5038181152- Botanical Research and Chemistry
- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Nicotinic Acetylcholine Receptors Study
Universidad Nacional Autónoma de México
2020-2024
Wheat germ agglutinin (WGA) demonstrates potential as an oral delivery agent owing to its selective binding carbohydrates and capacity traverse biological membranes. In this study, we employed differential scanning calorimetry molecular dynamics simulations comprehensively characterize the thermal unfolding process of both complete lectin four isolated domains. Furthermore, present nuclear magnetic resonance structures three domains that were previously lacking experimental in their forms....
Peptide-based therapy against cancer is a field of great interest for biomedical developments. Since it was shown that SK3 channels promote cell migration and metastatic development, we started using these as targets the development antimetastatic drugs. Particularly, tamapin (a peptide found in venom scorpion Mesobuthus tamulus) most specific toxin SK2 channel currently known. Considering this fact, designed diverse mutants based on three different hypotheses to discover new potent molecule...