A5078970144- Medical Imaging Techniques and Applications
- Computational Drug Discovery Methods
- Cardiac Imaging and Diagnostics
- Fluorine in Organic Chemistry
- Inorganic and Organometallic Chemistry
- Toxic Organic Pollutants Impact
- Advanced Polymer Synthesis and Characterization
- Synthesis and Reactions of Organic Compounds
- Radiopharmaceutical Chemistry and Applications
- Photopolymerization techniques and applications
- Insect and Pesticide Research
- Microbial Natural Products and Biosynthesis
- Muscle activation and electromyography studies
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Coordination Chemistry and Organometallics
- Eicosanoids and Hypertension Pharmacology
- Radical Photochemical Reactions
- Various Chemistry Research Topics
- Medical Imaging and Pathology Studies
- Machine Learning in Materials Science
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
National Institute for Materials Science
2020-2023
University of Tsukuba
2015-2023
Kitasato University
2019-2021
Kyoto University
1993-2020
Kyoto University Institute for Chemical Research
2015-2020
Kyoto Bunkyo University
2018-2020
Instituto de Investigaciones Químicas
2018
Institute for Advanced Medical Research
2016-2017
Keio University
2017
Tokyo Institute of Technology
1988-2005
An uncommon oxygen absorption/desorption behavior is reported for the cation-stoichiometric cobalt oxide, YBaCo4O7, structurally composed of two kinds layers corner-sharing CoO4 tetrahedra. We have found that YBaCo4O7+δ absorbs and desorbs up to δ ≈ 1.5 in a narrow temperature range below 400 °C. The uptake/release process highly reversible, being controlled by both partial pressure. Such large low-temperature oxygen-content tunability great promise regard applications related to, example,...
The binding properties of activated C3 to immune complexes were studied by using solubilization phenomenon as a model system. IgG or F(ab')2 precipitates solubilized the six isolated alternative pathway proteins, and analyzed SDS-PAGE. As result solubilization, we observed some high m.w. bands. Under reducing conditions, bands with 150,000 115,000 appeared in case complexes, respectively. Two-dimensional SDS-PAGE revealed that hydroxylamine treatment resulted dissociation 150,000-m.w....
The development of malignant hypertension was studied in stroke-prone spontaneously hypertensive rats (SHR) kept on 1% NaCl as drinking water. Along with salt-loading, blood pressure gradually increased and reached a severe level (greater than 230 mmHg), which followed by increases urinary protein 100 (mg/250 g body wt)/day) plasma renin concentration (PRC, from 18.9 +/- 0.1 to 51.2 19.4 (ng/ml)/h, mean SD). At this stage, renal small arteries arterioles showed sclerosis fibrinoid necrosis....
Recycling of epoxy resin and its composites is extremely difficult due to thermoset nature. In this study, we proposed the environmentally-friendly recycling system with dynamic covalent bonding in assistance cysteine-containing tripeptide, so-called glutathione. The glutathione attached on resulted cleavage disulfide bonds through thiol-disulfide exchange reaction between thiol group resin, followed by scission networks. Therefore, degraded residue was dissolved into chloroform. Finally,...
Three new groups of peptaibols, trichodecenins, trichorovins and trichocellins, have been isolated from conidia the fungus, Trichoderma viride. The structures trichodecenins-I -II were established by positive-ion fast-atom bombardment, collision-induced dissociation mass spectrometry two-dimensional NMR spectroscopy. Trichodecenins-I a (Z)-4-decenoyl group, six amino acid residues leucinol moiety in molecules. Trichodecenin-II was synthesized solution-phase method.
Oridonin, a new diterpenoid from Isodon japonicus and trichocarpus, has been shown to be ent-7β,20-epoxy-1β,6α,7α,l4α-tetrahydroxy-l6-kauren-15-one (I) on the basis of chemical spectroscopic evidence.
Epoxy resins incorporating aromatic disulfide bonds demonstrated improved adhesive properties with increasing temperature below their glass transition points.
Recently, artificial intelligence (AI)-enabled de novo molecular generators (DNMGs) have automated design based on data-driven or simulation-based property estimates. In some domains like the game of Go where AI surpassed human intelligence, humans are trying to learn from about best strategy game. To understand DNMG's molecule optimization, we propose an algorithm called characteristic functional group monitoring (CFGM). Given a time series generated molecules, CFGM monitors statistically...
The binding affinities of 16 7-substituted 2,3-dichlorodibenzo-p-dioxins for the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cytosolic receptor protein from male Wistar rats have been determined. EC50 value each compound was estimated by competitive displacement [3H]TCDD and data illustrated that differences between ligands were dependent on substituent (X) group. 7-trifluoromethyl-2,3-dichlorodibenzo-p-dioxin 1.95 X 10(-8) M greater than 1000-fold more active...
In the present study, visible light and sunlight-induced cationic polymerization of vinyl cyclic ethers using organotellurium compounds is demonstrated.
Trichorovins (TV)-I-XIV are new antibiotic peptides obtained from conidia of the fungus Trichoderma viride. The peptide mixture TVs was repeatedly fractionated by preparative HPLC until individual showed a single peak on their analytical chromatograms. Nevertheless, FAB-MS or NMR indicated that each TVs-I-XIV composed at least two components. We attempted to elucidate structures within fractions electrospray ionization (ESI)-MS, FAB-MS, FAB-MS/MS and NMR. generally have molecular weights...
We demonstrated that the introduction of disulfide bonds into epoxy adhesive could be used as a facile chromophoric indicator to predict strength.
Lewis acid (MgBr2)-catalyzed radical polymerization of acrylimides bearing chiral oxazolidinones gave highly isotactic polyacrylimides with up to >99% meso tetrad (mmm) selectivity. Polymerization in the absence atactic polymers 80% racemo diad (r) selectivity; selectivity was deliberately tuned from r mmm by varying conditions. The polyacrylimide quantitatively converted corresponding polyacrylates while preserving stereoregularity, thus providing a general method for synthesis polyacrylates.
Density functional theory (DFT) is a significant computational tool that has substantially influenced chemistry, physics, and materials science. DFT necessitates parametrized approximation for determining an expected value. Hence, to predict the properties of given molecule using DFT, appropriate parameters should be set each molecule. Herein, we optimize range-separated functionals (LC-BLYP CAM-B3LYP) via Bayesian optimization (BO) satisfy Koopmans' theorem. Our results demonstrate...