A5027928063- Forensic Toxicology and Drug Analysis
- Pharmacological Effects and Toxicity Studies
- Electroconvulsive Therapy Studies
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Cannabis and Cannabinoid Research
- Cancer Treatment and Pharmacology
- Opioid Use Disorder Treatment
- Neurological and metabolic disorders
- Metabolism and Genetic Disorders
- Substance Abuse Treatment and Outcomes
- Pharmaceutical studies and practices
- Treatment of Major Depression
- Diet and metabolism studies
- Psychedelics and Drug Studies
- Alcohol Consumption and Health Effects
- Drug-Induced Ocular Toxicity
- Attention Deficit Hyperactivity Disorder
- Pain Management and Opioid Use
- Parkinson's Disease and Spinal Disorders
- Analytical Chemistry and Chromatography
- Neurotransmitter Receptor Influence on Behavior
- Poisoning and overdose treatments
- Analytical Methods in Pharmaceuticals
- Alcoholism and Thiamine Deficiency
King's College London
2015-2024
Hanover College
2023
Humboldt State University
2023
Bournemouth University
2017
University of Cambridge
2013
Semmelweis University
2011-2012
Technical University of Darmstadt
2012
Riley Hospital for Children
2010
Indiana University – Purdue University Indianapolis
2010
Indiana University School of Medicine
2010
The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals.In double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling seed-based resting state functional connectivity (RSFC) were used produce spatial maps displaying changes cerebral blood flow (CBF) RSFC after administration. Participants underwent two arterial...
Dusting for prints: Antibody–magnetic-particle conjugates comprise protein-coated magnetic particles labeled with dye-tagged fragments (see picture). These bind to drugs and drug metabolites such as methadone benzoylecgonine that are deposited within a latent fingerprint. The provide means image the fingerprint enable identification of an individual whilst simultaneously providing evidence usage. Detailed facts importance specialist readers published "Supporting Information". Such documents...
Latent fingerprints provide a potential route to the secure, high throughput and non-invasive detection of drugs abuse.
Harm reduction has become the focus of public health initiatives and therapeutic intervention in management dependent drug use over last 20 years. The decade seen such approaches being extended to recreational use. Most harm have aimed inform users about risks ways minimizing risk. concept providing illicit with quality assessment their chosen is one possible that until recently received little attention. In response well-publicized 'ecstasy'-related deaths organizations some European...
Aims There is some evidence that monitoring methadone plasma concentration may be of benefit in dosage adjustment during maintenance therapy for heroin (opiate) dependence. However, the kinetics oral are incompletely characterized. We attempted to describe latter using a population approach combining intensive 57 h sampling data from healthy subjects with less sparse 24 opiate users. Methods Single doses rac ‐methadone were given 13 drug‐naive (7 men and 6 women) 17 users beginning (13 4...
Despite the common use of MDMA (ecstasy) in UK, mechanism underlying associated potentially fatal cerebral oedema is unclear. We used a new experimental approach working directly with clubbers to perform study on 30 (17 male) experienced (mean 6.6 years clubbing). Pre and post-clubbing measurements were performed compare plasma levels pituitary hormones (vasopressin, oxytocin), urine osmolality, urinary pH, sodium urea. Ecstasy consumption was con.rmed by using drug screening preand...
We have developed a sensitive HPLC method for measuring methadone in plasma and used it to establish that there is linear relationship between concentration dose over the range of 3-100 mg per day group 31 addicts. found good correlation (r = 0.89), with increasing by 0.263 mg/L every milligram consumed kilogram body weight. Five patients had unexpected high or low concentrations; this finding discussed.
Introduction Little is known about the extent and patterns of cannabis use in people with multiple sclerosis (MS). Methods MS patients attending neurology outpatient clinics at two hospitals London one Kent, UK completed a questionnaire. Results Questionnaires were by 254/337 (75%) patients. Forty-three per cent had used some stage (ever users). Of these, 68% (75/110) to alleviate symptoms (MS-related use). Forty-six (18%) last month (current users), whom 12% (31/254) it for symptom relief....
Aims Although methadone is widely used to treat opiate dependence, guidelines for its dosage are poorly defined. There increasing evidence suggest that a strategy based on plasma drug monitoring may be useful detect non‐compliance. Therefore, we have developed population‐based pharmacokinetic (POP‐PK) model characterises adaptive changes in kinetics. Methods Sparse rac‐methadone concentrations measured 35 opiate‐users were assessed using the P‐Pharm software. The final structural comprised...
Route of administration has a profound, but often overlooked, influence on the actual experience drug use itself, risk resulting development dependence, and nature harms to which users are exposing themselves. These three areas reviewed. The route effect is considered first with regard overall effectiveness absorption, also speed onset effect. implications for dependence cover animal human laboratory studies reinforcement schedules, epidemiological studies, attitudes themselves different...
OBJECTIVE: To examine the composition of illicitly manufactured "ecstasy" tablets sold on UK drugs market. METHODS: Analysis by gas chromatography 25 illicit ecstasy handed in under amnesty to Leeds Addiction Unit. RESULTS: Illicitly contain a range ingredients, widely differing concentrations, and even with same brand name have variable concentrations active ingredients. Concentrations 3,4-methylenedioxymethamphetamine (MDMA) more popularly known as ecstasy, varied 70-fold between tablets....
To evaluate the impact of excessive alcohol consumption on health-related quality life patients receiving methadone treatment for opioid dependence.A cross-sectional survey.One hundred and ninety-two attending out-patient clinics in south-east England, United Kingdom.Quality (QoL) was assessed using Medical Outcomes Study: General Health Survey, Short Form (SF-12). Alcohol Use Disorders Identification Test (AUDIT).Approximately one-third sample (57/192) were AUDIT-positive (score > or = 8)...
Abstract Aim. To evaluate the association between coping self‐efficacy and persistent use of heroin by patients enrolled in a methadone treatment program. Design Methods. Cross‐sectional survey. One hundred ninety‐one attending outpatient clinics South‐East England, United Kingdom. Validated questionnaires were used to assess drug (Maudsley Addiction Profile), alcohol (Alcohol Use Disorders Identification Test), mental health (Hospital Anxiety Depression Scale) (brief 8‐item Drug Taking...
There is evidence that plasma methadone measurements may be of benefit in dosage adjustment during maintenance treatment for opiate dependence. However, to date the kinetics oral rac-methadone have been poorly characterized. We describe concentration-time data collected from 35 addicts.Oral doses were given 24 male and 11 female addicts attending a community-based drug centre.Plasma concentrations measured by liquid chromatography (HPLC).Plasma patients prescribed order complex incorporating...
In this study we investigate the association of cytochrome P450 enzyme CYP2D6, catechol- O-methyl transferase (COMT, Val158Met) and serotonin transporter promoter ( 5-HTTLPR) genotypes on change in cortisol concentration following 3, 4-methylenedioxy-methamphetamine (MDMA, ‘ecstasy’) consumption. Forty-eight subjects (30 males, mean age 23 years), self-nominating regular clubbers provided ‘in field’ pre- post-clubbing biological samples associated information. Of 39 who a urine sample, 21...