A5071332026- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Chemical synthesis and alkaloids
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Complementary and Alternative Medicine Studies
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Paranormal Experiences and Beliefs
- Traumatic Brain Injury and Neurovascular Disturbances
- Natural Compound Pharmacology Studies
- Neuroscience and Neuropharmacology Research
- Forensic Toxicology and Drug Analysis
- Cerebrospinal fluid and hydrocephalus
- Nicotinic Acetylcholine Receptors Study
- Mindfulness and Compassion Interventions
- Neuroscience and Music Perception
- Schizophrenia research and treatment
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Psychotherapy Techniques and Applications
- Religious Studies and Spiritual Practices
Beckley Foundation
2015-2024
Universidad de Zaragoza
2021
Centro de Investigación Biomédica en Red
2017
Hospital de Sant Pau
2017
Universitat Autònoma de Barcelona
2017
Centro de Investigación Biomédica en Red de Salud Mental
2017
Russian Academy of Sciences
2008-2009
Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for various conditions, including end-of-life anxiety, obsessive-compulsive disorder, and smoking alcohol dependence, with promising preliminary results. Here, we aimed to investigate feasibility, safety, efficacy patients unipolar treatment-resistant depression.In this open-label feasibility trial, 12 (six men, six women)...
Entropy is a dimensionless quantity that used for measuring uncertainty about the state of system but it can also imply physical qualities, where high entropy synonymous with disorder. applied here in context states consciousness and their associated neural dynamics, particular focus on psychedelic state. The considered an exemplar primitive or primary preceded development modern, adult, human, normal waking consciousness. Based neuroimaging data psilocybin, classic drug, argued defining...
Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest their therapeutic potential, we continue to know very little about how they work the brain. Here used psilocybin, classic psychedelic found magic mushrooms, and task-free functional MRI (fMRI) protocol designed capture transition from normal waking consciousness state. Arterial spin labeling perfusion blood-oxygen level-dependent (BOLD) fMRI were map cerebral blood flow changes venous oxygenation...
Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. Here, we report on safety and efficacy for up to 6 months an open-label trial of psilocybin treatment-resistant depression. Twenty patients (six females) (mostly) severe, unipolar, major depression received two oral doses (10 25 mg, 7 days apart) a supportive setting. Depressive symptoms were assessed from 1 week post-treatment, the self-rated QIDS-SR16 as primary...
Significance Lysergic acid diethylamide (LSD), the prototypical “psychedelic,” may be unique among psychoactive substances. In decades that followed its discovery, magnitude of effect on science, arts, and society was unprecedented. LSD produces profound, sometimes life-changing experiences in microgram doses, making it a particularly powerful scientific tool. Here we sought to examine effects brain activity, using cutting-edge complementary neuroimaging techniques first modern study LSD....
Community-based studies suggest that cannabis products are high in Δ 9 -tetrahydrocannabinol (THC) but low cannabidiol (CBD) particularly hazardous for mental health. Laboratory-based ideal clarifying this issue because THC and CBD can be administered pure form, under controlled conditions. In a between-subjects design, we tested the hypothesis pre-treatment with inhibited THC-elicited psychosis cognitive impairment. Healthy participants were randomised to receive oral 600mg ( n=22) or...
Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded healthy human participants with magnetoencephalography after intravenous infusion of psilocybin—prodrug nonselective serotonin 2A receptor agonist classic psychedelic psilocin. Psilocybin reduced spontaneous cortical power from 1 to 50 Hz posterior association cortices, 8 100 frontal cortices. Large...
Ego-disturbances have been a topic in schizophrenia research since the earliest clinical descriptions of disorder. Manifesting as feeling that one's "self," "ego," or "I" is disintegrating border between self and external world dissolving, "ego-disintegration" "dissolution" also an important feature psychedelic experience, such produced by psilocybin (a compound found "magic mushrooms"). Fifteen healthy subjects took part this placebo-controlled study. Twelve-minute functional MRI scans were...
Abstract Personality is known to be relatively stable throughout adulthood. Nevertheless, it has been shown that major life events with high personal significance, including experiences engendered by psychedelic drugs, can have an enduring impact on some core facets of personality. In the present, balanced‐order, placebo‐controlled study, we investigated biological predictors post‐lysergic acid diethylamide (LSD) changes in Nineteen healthy adults underwent resting state functional MRI scans...
Background Lysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in marked and novel way. This study sought to examine the acute mid-term psychological effects of LSD controlled study. Method A total 20 healthy volunteers participated this within-subjects Participants received (75 µ g, intravenously) on one occasion placebo (saline, another, balanced order, with at least 2 weeks separating sessions. Acute subjective were measured...
Psilocybin is a classic psychedelic and candidate drug model of psychosis. This study measured the effects psilocybin on resting-state network thalamocortical functional connectivity (FC) using magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions placebo in 2 task-free scans. Primary analyses focused changes FC between default-mode- (DMN) task-positive (TPN). Spontaneous activity DMN orthogonal to spontaneous TPN, it well known that these networks...
Perturbing a system and observing the consequences is classic scientific strategy for understanding phenomenon. Psychedelic drugs perturb consciousness in marked novel way thus are powerful tools studying its mechanisms. In present analysis, we measured changes resting-state functional connectivity (RSFC) between standard template of different independent components analysis (ICA)-derived resting state networks (RSNs) under influence two psychoactive drugs, stimulant/psychedelic hybrid,...
Psilocybin is a classic psychedelic drug that has history of use in psychotherapy. One the rationales for its was it aids emotional insight by lowering psychological defences.To test hypothesis psilocybin facilitates access to personal memories and emotions comparing subjective neural responses positive autobiographical under placebo.Ten healthy participants received two functional magnetic resonance imaging scans (2 mg intravenous v. saline), separated approximately 7 days, during which...
Abstract There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions self-experience, depression. Accumulating preclinical evidence emphasizes role glutamate system acute action drug on brain and behavior; however this has never been tested humans. Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal imaging approach demonstrated that psilocybin (0.17...
Recent studies have supported the safety and efficacy of psychedelic therapy for mood disorders addiction. Music is considered an important component in treatment model, but little empirical research has been done to examine magnitude nature its therapeutic role. The present study assessed influence music on acute experience clinical outcomes therapy. Semi-structured interviews inquired about different ways which influenced 19 patients undergoing with psilocybin treatment-resistant...
Ayahuasca is a plant tea containing the psychedelic 5-HT2A agonist N,N-dimethyltryptamine and harmala monoamine-oxidase inhibitors. Acute administration leads to neurophysiological modifications in brain regions of default mode network, purportedly through glutamatergic mechanism. Post-acutely, ayahuasca potentiates mindfulness capacities volunteers induces rapid sustained antidepressant effects treatment-resistant patients. However, mechanisms underlying these fast maintained are poorly...
Microdosing is the practice of regularly using low doses psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however, such accounts are potentially biased by placebo effect. This study used a ‘self-blinding’ citizen science initiative, where participants were given online instructions on how to incorporate control into their routine without clinical supervision. The was completed 191 participants, making it largest placebo-controlled trial...
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute long-term psychological outcomes, such personality changes. These are particularly intriguing, given a decrease of is robust indicator loss consciousness (e.g., from wakefulness to sleep). However, little known about how context impacts the entropy-enhancing psychedelics, which carries important implications for it can be...
The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals.In double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling seed-based resting state functional connectivity (RSFC) were used produce spatial maps displaying changes cerebral blood flow (CBF) RSFC after administration. Participants underwent two arterial...
Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in Amazon for ritual and medicinal purposes, by interested individuals worldwide. Animal studies recent clinical research suggests that B. preparations show antidepressant activity, therapeutic effect has been linked to hippocampal neurogenesis. Here we report harmine, tetrahydroharmine harmaline, three main alkaloids present caapi, harmine metabolite harmol, stimulate adult neurogenesis vitro. In...