A5061446163- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Blind Source Separation Techniques
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- ECG Monitoring and Analysis
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Phosphodiesterase function and regulation
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Blood Pressure and Hypertension Studies
- Traffic and Road Safety
- Inorganic and Organometallic Chemistry
- Neurological disorders and treatments
- Traffic Prediction and Management Techniques
- Receptor Mechanisms and Signaling
- Vitamin C and Antioxidants Research
- Mind wandering and attention
- Analytical Chemistry and Chromatography
- Transportation Systems and Logistics
King's College London
2010-2023
Birkbeck, University of London
2022
University of Oxford
2019-2020
Warneford Hospital
2019
Cognitive Neuroimaging Lab
2010-2015
South London and Maudsley NHS Foundation Trust
2014
Centre for Mental Health
2014
Wellcome Centre for Human Neuroimaging
2013
Community-based studies suggest that cannabis products are high in Δ 9 -tetrahydrocannabinol (THC) but low cannabidiol (CBD) particularly hazardous for mental health. Laboratory-based ideal clarifying this issue because THC and CBD can be administered pure form, under controlled conditions. In a between-subjects design, we tested the hypothesis pre-treatment with inhibited THC-elicited psychosis cognitive impairment. Healthy participants were randomised to receive oral 600mg ( n=22) or...
Finding reliable endophenotypes for psychosis could lead to an improved understanding of aetiology, and provide useful alternative phenotypes genetic association studies. Resting quantitative electroencephalography (QEEG) activity has been shown be heritable over time. However, QEEG research in patients with inconsistent even contradictory findings, studies at-risk populations are scarce. Hence, this study aimed investigate whether resting represents a candidate endophenotype psychosis.
Impairments in gamma-aminobutyric acid (GABAergic) interneuron function lead to gamma power abnormalities and are thought underlie symptoms people with schizophrenia. Voltage-gated potassium 3.1 (Kv3.1) 3.2 (Kv3.2) channels on GABAergic interneurons critical the generation of oscillations suggesting that targeting Kv3.1/3.2 could augment modulate oscillation generation. Here, we studied effect a novel channel modulator, AUT00206, resting state frontal We found significant positive...
Gamma oscillations (>30 Hz) in the brain are involved attention, perception and memory. They altered various pathological states, as well by neuropharmaceuticals, so that they of interest drug clinical investigations. However, when human electroencephalogram is recorded on scalp, this neural high-frequency signal buried under a range other electrical signals such that, without careful handling, recordings cannot be considered reliable. The artefacts concern originate from: power line...
An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia.The objective of this study is to determine the effect intravenous THC compared placebo on high-frequency EEG.A double-blind cross-over design was used. In resting state, high-beta low-gamma magnitude (21-45 Hz) investigated (n = 13 pairs + 4 only). Also,...
Preclinical studies indicate that high-frequency oscillations, above 100 Hz (HFO:100-170 Hz), are a potential translatable biomarker for pharmacological studies, with the rapid acting antidepressant ketamine increasing both gamma (40-100 Hz) and HFO.To assess effect of uncompetitive NMDA antagonist ketamine, D-cycloserine (DCS), which acts at glycine site on receptors HFO in humans.We carried out partially double-blind, 4-way crossover study 24 healthy male volunteers. Each participant...
Neural oscillations in the gamma band are of increasing interest, but separating them from myogenic electrical activity has proved difficult. A novel algorithm been developed to reduce effect tonic scalp and neck muscle on EEG. This uses mathematical modelling fit individual spikes then subtracts data. The method was applied detection motor associated two separate groups eight subjects using different sampling rates. reproducible increase high (65-85 Hz) magnitude occurred immediately after...
In this paper, a novel source extraction method is proposed for removing ballistocardiogram (BCG) artifact from EEG. BCG appears in EEG signals recorded simultaneously with functional magnetic resonance imaging. The semiblind algorithm based on linear prediction technique. We define cost function according to joint short- and long-term strategy extract the sources. call SLTP-BSE standing blind extraction. objective of work 1) model temporal structure sources using short-term 2) impose prior...
Background: Patients with schizophrenia have significant cognitive deficits, which may profoundly impair quality of life. These deficits are also evident at the neurophysiological level patients demonstrating altered event-related potential in several stages processing compared to healthy controls; within auditory domain, for example, there replicated alterations Mismatch Negativity, P300 and Auditory Steady State Response. However, no approved pharmacological treatments schizophrenia. Aims:...
Aspects of cognitive function decline with age. This phenomenon is referred to as age-related (ARCD). Improving the understanding these changes that occur part ageing process can serve enhance detection more incapacitating neurodegenerative disorders such Alzheimer's disease (AD). In this study, we employ novel methods assess ARCD by exploring utility alpha3/alpha2 electroencephalogram (EEG) power ratio - a marker AD, and virtual reality (VR) functional cognition task VStore, in...
The clinical high-risk for psychosis (CHR-P) paradigm was introduced to detect individuals at risk of developing and establish preventive strategies. While current prediction outcomes in the CHR-P state is based mostly on assessment presenting features, several emerging biomarkers have been investigated an attempt stratify according their individual trajectories refine diagnostic process. However, heterogeneity across subgroups a key challenge that has limited impact strategies, as validity...
In this paper the problem of removing Ballistocardiogram (BCG) artifact from EEG signal is addressed. BCG removal an important task in analysis simultaneous EEG-fMRI data. We propose a new method by combining independent component (ICA) and discrete Hermite transform (DHT) for purpose. Discrete powerful technique which able to model with no assumption about its shape. This feature makes DHT appropriate tool be combined ICA artifact. show that proposed hybrid ICA-Hermite can compensate...