A5009675464- Celiac Disease Research and Management
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Microscopic Colitis
- Food Allergy and Anaphylaxis Research
- Integrated Circuits and Semiconductor Failure Analysis
- Force Microscopy Techniques and Applications
- Student Assessment and Feedback
- Higher Education Learning Practices
- Laser Material Processing Techniques
- Eosinophilic Esophagitis
- Whipple's Disease and Interleukins
- Diamond and Carbon-based Materials Research
- Tunneling and Rock Mechanics
- Toxin Mechanisms and Immunotoxins
- Facial Rejuvenation and Surgery Techniques
- Magnetic Properties and Applications
- Xenotransplantation and immune response
- Educational Assessment and Improvement
- Contact Dermatitis and Allergies
- Preterm Birth and Chorioamnionitis
- Interdisciplinary Research and Collaboration
- Body Contouring and Surgery
- Diverse Education and Engineering Focus
- Botulinum Toxin and Related Neurological Disorders
Northwestern University
2024
Technological University Dublin
2020-2022
University College Dublin
1999-2016
I-Form Advanced Manufacturing Research Centre
2004-2012
St. James's Hospital
2006-2012
Trinity College Dublin
2008-2012
Boston Children's Hospital
2010
Molecular Medicine Ireland
2008
University of Guelph
2005
National University of Ireland
2002
Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted that regulate inflammatory responses through the rapid production of cytokines. In this article, we show circulating MAIT depleted in obese adults, and depletion is associated with diabetic status. Circulating more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated insulin resistance. were enriched adipose tissue (AT) compared blood. AT cells, but not capable producing IL-10. from subjects,...
Abstract A complete cytotoxic profile of exposure to silver (AgNP) nanoparticles investigating their biological effects on the innate immune response circulating white blood cells is required form a understanding risk posed. This was explored by measuring AgNP‐stimulated gene expression pro‐inflammatory cytokines interleukin‐1 (IL‐1), interleukin‐6 (IL‐6) and tumour necrosis factor‐alpha (TNF‐α) in THP‐1 monocytes. further study, human monocytes extracted from cohort samples, carried out...
This paper is concerned with the effect of coatings on performance tungsten carbide (WC) drills in drilling carbon fibre-reinforced epoxy. Although composites are becoming increasing popular, there a deficit existing knowledge composites, and particular epoxy resins. Two coated drills, namely titanium nitride (TiN)-coated diamond-like (DLC)-coated were investigated for comparative purposes an uncoated drill. The testing involved series consecutive holes. During these tests thrust forces...
The COVID-19 pandemic resulted in a rapid pivot to online learning across many higher education institutions globally. This paper investigates what extent assessment strategies changed as result of this pivot. It explores the case Technological University Dublin (TU Dublin) Ireland and finds that 95% respondents altered their practices some way. Beyond identifying changing practice, also develops TARC (Typology Assessment Responses COVID-19) model which shows four categories responses....
Synopsis This preliminary study was undertaken to provide data from which a more comprehensive investigation establish the safety in-use of cosmetic talcs could be designed. Methods for collecting and analysing respirable talc generated during use loose face powder adult baby dusting powders were established. Respirable particles in air separated larger size by means cyclone collected on membrane filters. The dust dissolved acid solution analysed magnesium atomic absorption spectroscopy....
Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion gluten in genetically susceptible individuals. Genes within HLA-DQ locus are considered to contribute some 40% genetic influence on this disease. However, information other causing genes sparse. Since enterocytes play central role coeliac pathology, aim study was examine gene expression highly purified isolate these cells taken from patients with active Epithelial were isolated duodenal biopsies...
Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The exhibits many features of an autoimmune disorder. These include the production highly specific anti-endomysial autoantibodies directed against enzyme tissue transglutaminase. It well accepted wheat-, barley- and rye-based foods should be excluded gluten-free diet. Although several studies report oats ingestion safe this diet, potential toxicity remains controversial. In current study,...
The production of silicon substrates for integrated circuits continues to set standards in levels precision form and finish tolerances required surface generation processes. Extreme are specified a range parameters such as total thickness variation, global local planarity, over substrate dimensions up 300mm diameter (current-generation wafer). These related the ‘design rule’ each microprocessor memory unit. economic technological environment an industry that demands is reviewed. general...
Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. The detection of autoantibodies directed against tTG a highly specific marker disease; however, it unclear if there role for these process. aim this study was to investigate whether catalytic triad targeted by autoantibodies.A full-length wild-type recombinant novel site-directed mutagenic variant lacking were produced Escherichia coli. Serum samples from 61 biopsy-proven 10...
Production of autoantibodies to the enzyme tissue transglutaminase (tTG) is a hallmark coeliac disease (CD). We have previously demonstrated that immumoglobulin (Ig) A response tTG in adult CD specifically targets its catalytic core region, containing active-site triad amino acids. The aim present study was investigate this phenomenon paediatric patients with CD, and elucidate contribution each residue epitopes recognised. specificity IgG anti-tTG also investigated compared IgA response,...