A5101796877- Celiac Disease Research and Management
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Urticaria and Related Conditions
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Global Health Workforce Issues
- Eosinophilic Disorders and Syndromes
- Musculoskeletal Disorders and Rehabilitation
- Autoimmune Bullous Skin Diseases
- Dental Education, Practice, Research
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Cardiac, Anesthesia and Surgical Outcomes
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Lung Cancer Research Studies
- Neonatal Respiratory Health Research
- Liver Diseases and Immunity
- IL-33, ST2, and ILC Pathways
University of Washington
2024
Fred Hutch Cancer Center
2024
Bridger Photonics (United States)
2023
St. James's Hospital
1992-2008
Trinity College Dublin
1986-2008
University Hospital Galway
1998
University of Oxford
1993
St. Jude Children's Research Hospital
1989-1990
Emory University
1986
Baylor College of Medicine
1986
Summary: Research on precancers, as defined at-risk tissues and early lesions, is of high significance given the effectiveness intervention. We discuss need for risk stratification to prevent overtreatment, an emphasis role genetic epigenetic aging when considering risk, importance integrating macroenvironmental factors with molecules cells in lesions normal developing effective intervention health policy strategies.
SUMMARY The antiphospholipid syndrome is a disorder characterized by recurrent thrombosis and the presence of antibodies specific to phospholipids. However, diagnosis this hampered lack laboratory test. In study an ELISA for measurement solid-phase β2-glycoprotein I (β2-GPI) was established compared with anticardiolipin syndrome. Significantly elevated levels β2-GPI were found in all patients definite (median = 91 AU). Marginally observed 5% systemic lupus erythematosus (SLE; median 4 AU),...
C1-inhibitor (C1-Inh) is an important inhibitor of the inflammatory response and deficiency this inhibitor, which may be hereditary or acquired, associated with recurrent episodes edema. Recently, autoimmune form angioedema has been described that functional C1-Inh autoantibody impedes function. In report we describe isolation from monocytes plasma a patient demonstrate patient's secrete structurally functionally normal C1-Inh, but show protein circulates in inactive, altered form....
Analysis of remission induction rates for 1,768 children (1.5 to 11 years) and 425 adolescents (greater than or equal with acute lymphoid leukemia (ALL), event-free survival times 570 147 adolescents, disclosed that fared significantly worse by both measures treatment outcome (P = .0001). Adolescents either T cell non-T ALL entered less often did .02 P .001, respectively). Within each the major immunophenotypes ALL, had shorter duration continuous complete remission: early pre-B (non-B, non...
SUMMARY The immune response of PBMC to gliadin was investigated in patients with coeliac disease (CoD) by examining proliferation, MHC restriction and cytokine production. Gliadin induced low levels proliferation 63% eight untreated patients, 32% 28 treated 35% 31 healthy control subjects. In studies, the proliferative inhibited (range 47–98% inhibition) presence a MoAb HLA-DR each three donors studied. Using flow cytometry, increased expression activation markers (HLA-DR IL-2R) demonstrated...
Summary There is increasing evidence that proinflammatory cytokines contribute to many of the small intestinal features in coeliac disease. The aim study was investigate expression two cytokines, migration inhibition factor (MIF) and tumour necrosis alpha (TNF-α) duodenal biopsy specimens from patients with disease on a gluten-free diet normal control subjects. A flow cytometric system used analyse intracellular protein levels MIF TNF-α freshly isolated cells biopsies taken 12 treated 10...
Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. The detection of autoantibodies directed against tTG a highly specific marker disease; however, it unclear if there role for these process. aim this study was to investigate whether catalytic triad targeted by autoantibodies.A full-length wild-type recombinant novel site-directed mutagenic variant lacking were produced Escherichia coli. Serum samples from 61 biopsy-proven 10...
Tissue transglutaminase (tTG) has recently been identified as the antigenic target recognised by anti-endomysial antibodies in patients with coeliac disease. In this study, an enzyme-linked immunosorbent assay (ELISA) is used to measure IgA, IgG and IgM tTG disease a variety of other inflammatory disorders; compared standard immunofluorescence test detect endomysial (EMA). samples tested, 3% control sera (n=146), 83% EMA-positive (n=29), 9% Graves’ (n=94), 12% antimitochondrial...
In coeliac disease, following the introduction of a gluten-free diet, monitoring mucosal disease activity requires repeated small intestinal biopsies. If test measuring circulating inflammatory marker was available, this would be clinically valuable.To determine if levels soluble CD163, scavenger receptor shed by tissue macrophages, correlated with lesion in disease.Serum samples were collected from 131 patients untreated 40 treated 92 non-coeliac control subjects and healthy controls. A...
Abstract We describe a patient with the lupus anti‐coagulant who had recurrent episodes, over 2 year period, of severe and disseminated intravascular coagulopathy. This also positive serological assays for syphilis anti‐cardiolipin antibodies. Associated coagulopathy were co‐expressed episodes liver disease, ultimately terminating in fulminant failure. At autopsy features characteristic Budd‐Chiari syndrome. is first report to document how consumptive may present as dominant feature...
Summary Background In coeliac disease, wheat, barley and rye are traditionally excluded in the gluten‐free diet. However, few studies have examined small intestinal immune response to rye. Aim To investigate immunogenicity of prolamins (hordein secalin respectively) comparison with wheat gliadin. Methods Duodenal biopsies from 22 patients 23 disease controls were cultured for 4 h gliadin, hordein or compared culture medium alone. Proinflammatory cytokines, interferon‐ γ interleukin‐2,...
Some patients with coeliac disease, despite strict adherence to a gluten-free diet, continue have significant symptoms and/or severe small intestinal histological lesion. The term "refractory disease" (rCD) is used describe this condition. purpose of study was investigate the value tissue molecular markers reported help in diagnosis rCD.Details on 61 suspected rCD were collected. clinical and laboratory findings these carefully evaluated, part determine whether adhering diet. co-expression...
Thirty patients with psoriatic arthropathy (PA) were age- and sex-matched plaque psoriasis alone to investigate a possible link between Sjögren's syndrome (SS) PA. The results of clinical examination, Schirmer's test, maximal stimulated salivary flow rate, haematological serological investigations compared in the two groups. Median rate was significantly reduced PA suggesting that glands are affected this condition. One patient had SS.
The Catastrophic Anti-phospholipid Syndrome (CAPS) is a rare acute clinical syndrome associated with serum anti-phospholipid antibodies (aPL). It rarely preceded by precipitating event. may occur as primary event or be auto-immune diseases. We report fatal case occuring post-endoscopic retrograde cholangio-pancreatography (ERCP) in patient Systemic Lupus Erythematosus (SLE), positive lupus anticoagulant and negative IgG IgM anti-cardiolipin titres. diagnostic therapeutic difficulties of such...
C1-inhibitor (C1-Inh) is a serine esterase proteinase inhibitor (serpin) which plays an important role in regulating proteinases of the early inflammatory response. In this study, we describe novel and versatile polyclonal antibody capture assay to examine C1-Inh consumption vivo. This has advantages over previously described methods measuring as it allows assessment relative amounts native, complexed cleaved circulating plasma. By using antibodies specific for other complement proteins, was...