A5087517976- Genomics and Chromatin Dynamics
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Fungal and yeast genetics research
- Platelet Disorders and Treatments
- Disability Education and Employment
- Developmental Biology and Gene Regulation
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- RNA Research and Splicing
- Digital Imaging for Blood Diseases
- Erythropoietin and Anemia Treatment
- Histone Deacetylase Inhibitors Research
- CRISPR and Genetic Engineering
- Epilepsy research and treatment
- PARP inhibition in cancer therapy
- Long-Term Effects of COVID-19
- Occupational Therapy Practice and Research
- AI in cancer detection
- Phytochemicals and Medicinal Plants
- Iron Metabolism and Disorders
- Endoplasmic Reticulum Stress and Disease
- Fungal Plant Pathogen Control
- Telemedicine and Telehealth Implementation
- Genetics, Bioinformatics, and Biomedical Research
University of Massachusetts Chan Medical School
2017-2025
D.Y. Patil University
2020-2021
Saveetha University
2016
University of Massachusetts Amherst
2011-2014
Wayne State University
2008-2011
Summary Dollar spot, caused by S clerotinia homoeocarpa , is a prevalent turfgrass disease, and the fungus exhibits widespread fungicide resistance in N orth A merica. In previous study, an ABC ‐ G transporter, ShatrD was associated with practical field to demethylation inhibitor ( DMI ) fungicides. Mining of transporters, also known as pleiotropic drug PDR from RNA eq data gave assortment transcripts, several high sequence similarity functionally characterized transporters B otrytis cinerea...
The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC) complexes. and its associated HDAC have been shown to critical roles in both development regulation cell cycle progression. Although multiple isoforms reported simple complex eukaryotic organisms, mechanisms by which such regulate specific biological processes are still largely uncharacterized. To gain insight into how isoform-specific function contributes growth metazoan organism, we affinity-purified...
The importance of neurorehabilitation services for people with disabilities is getting well-recognized in low- and middle-income countries (LMICs) recently. However, accessibility to the same has remained most significant challenge, these contexts. This especially because non-availability trained specialists availability centers only urban cities owned predominantly by private healthcare organizations. In current COVID-19 pandemic, members Task Force research at Indian Federation...
Abstract SIN3 is a component of histone deacetylase complex known to be important for transcription repression. While multiple isoforms have been reported, little about their relative expression or role in development. Using combination techniques, we determined that expressed throughout the Drosophila life cycle. The pattern each individual isoform, however, distinct. Knock down all reveals requirement this protein embryonic and larval periods. Taken together, data suggest required...
Early erythroid progenitors were originally defined by their colony-forming potential in vitro and classified into burst-forming "units" known as BFU-e CFU-e. Until recently, methods for the direct prospective complete isolation of pure CFU-e from freshly isolated adult mouse bone marrow not available. To address this gap, a single-cell RNA-seq (scRNAseq) dataset was analyzed expression genes coding cell surface markers. This analysis combined with fate assays, allowing development novel...
Feedback control of erythropoiesis exemplifies conflicting goals in tissue homeostasis: maintaining fast reactivity to stress while minimizing proliferative burden on progenitors the steady state. Here we show that these are tuned through combinatorial action cytokines. We find IL-17A, a pro-inflammatory cytokine, mediates striking synergism with negative feedback signal erythropoietin (Epo) vivo, accelerating erythropoietic response hypoxia. A model shows increased may occur two cell...
Summary The Saccharomyces cerevisiae PHO5 gene product accounts for a majority of the acid phosphatase activity. Its expression is induced by basic helix–loop–helix (bHLH) protein, Pho4p, in response to phosphate depletion. Pho4p binds predominantly two UAS elements (UASp1 at −356 and UASp2 −247) promoter. Previous studies from our lab have shown cross‐regulation different biological processes bHLH proteins. This study tested ability all yeast proteins regulate identified inositol‐mediated...
The role of the Sin3A transcriptional corepressor in regulating cell cycle is established various metazoans. Little known, however, about signaling pathways that trigger or are triggered by function. To discover genes work similar opposing to during development, we have performed an unbiased screen deficiencies Drosophila third chromosome. Additionally, a targeted loss function identify genetically interact with Sin3A. We identified encode proteins involved regulation gene expression, and...
We developed a novel knockdown strategy to examine cell-specific gene function in Caenorhabditis elegans. In this null mutation any is replaced with genetically stable transgene that contains wild-type copy of the fused 3' tag targets mRNA transcript for degradation by host nonsense-mediated decay (NMD) machinery. NMD-defective animals, tagged expressed at levels similar endogenous it and translated into protein fully rescues function. Cell-specific activation NMD cell autonomously knocks...
A 19-year-old male with autism, intellectual disability (ID), and obsessive–compulsive disorder (OCD) presented difficulty in self-determined routine task performances. Tele assessment was performed pre- post-tele-occupational therapy (OT) intervention, using Yale Brown Obsessive–Compulsive Scale (Y-BOCS), Self-Determination Observation Checklist (SDOC), American Institutes for Research Self Determination (AIRSDS) parent educator form, Routine Task Inventory-Expanded (RTI-E), to assess...
Early erythroid progenitors were originally defined by their colony-forming potential in vitro and classified into burst-forming "units" known as BFU-e CFU-e. Until recently, methods for the direct prospective complete isolation of pure CFU-e from freshly isolated adult mouse bone marrow not available. To address this gap, a single-cell RNA-seq (scRNAseq) dataset was analyzed expression genes coding cell surface markers. This analysis combined with fate assays, allowing development novel...
ABSTRACTObjective: Estimation of serum zinc and copper levels in anemic patients.Methods: The study design included 30 subjects presenting to clinical laboratory, global hospitals. were divided into 2 groups. TheGroup 1 consists 15 healthy individuals Group patients.Results: evaluated patients. found be significantly lower inanemic patients when compared with normal individuals.Conclusion: Thus, the concludes that is less control individuals.Hence, it important add adequate amount rich food...