Background The relationship between physical activity and incident pancreatic cancer is poorly defined, the evidence to date inconsistent, largely due small sample sizes insufficient outcomes. Using UK Biobank cohort dataset, association levels at recruitment ductal adenocarcinoma (PDAC) follow-up was analysed. Method Physical activity, key exposure, quantified using Metabolic Equivalent Task (MET) values categorised into walking, moderate, vigorous activity. These categories were each...

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is insidious, with only 15–20% of those diagnosed suitable for surgical resection as it either too advanced and has invaded local structures or already spread to distant sites. The associated tumor microenvironment provides a protective shield which limits the efficacy chemotherapeutic agents, but also impairs delivery nutrients required PDAC cells. To compensate this, metabolic adaptions occur provide alternative sources fuel. aim this...

Background: The role of dysglycaemia as a risk marker for Pancreatic Ductal Adenocarcinoma (PDAC) is uncertain. We investigated the relationship between glycated haemoglobin (HbA1c) and incident PDAC using retrospective cohort study within UK Biobank. Methods: A involving 499,804 participants from Biobank was undertaken. Participants were stratified by diabetes mellitus (DM) status, then HbA1c values < 42 mmol/mol, 42–47 or ≥48 mmol/mol. Cox proportional hazard models used to describe...

ABSTRACT Background and Aims The impact of metabolic syndrome (MetS) traits on chronic kidney disease (CKD) risk in dysfunction‐associated steatotic liver (MASLD) is unknown. We investigated the type number MetS fibrosis prevalent CKD incident end‐stage renal (ESRD) SLD. Methods 234 488 UK Biobank participants' were analysed. Hepatic steatosis index (> 36 for SLD, < 30 no SLD) MRI‐proton density fat fraction (≥ 5.56%) used to identify identified using MASLD criteria. Advanced (FIB‐4...

Pancreatic cancer (PC) is the fifth leading cause of cancer-related death in UK. The incidence PC increasing, with little or no improvement overall survival and best chance for long-term patients relies on early detection surgical resection. In this study, we propose use a diagnostic algorithm that combines tests pancreatic exocrine function (faecal elastase-1 (FE-1) test 13C-mixed triglyceride (13C-MTG) breath test) to identify urgently needs imaging studies. This prospective pilot (proof...

Paunch contents are the recalcitrant, lignocellulose-rich, partially-digested feed present in rumen of ruminant animals. Cattle forage Europe is primarily from perennial and Italian ryegrasses and/or white clover, so paunch forage-fed cattle enriched these feedstuffs. Globally, due to its underutilisation, potential energy annually represents an loss 23,216,548,750–27,804,250,000 Megajoules (MJ) financial up ~€800,000,000. Therefore, this review aims describe progress made to-date optimising...

Abstract Background Oesophageal defects following cancer resection, dilatation or Boerhaave’s syndrome are increasingly managed with endoscopic approaches. Surgical management is associated high morbidity and mortality. Pigtails stents (PS), oesophageal negative pressure therapy (eso-sponge) have all been described variation in efficacy. Microtech VAC (MVS) emerged as a means of providing an luminal stent to the mediastinum. Method Between June 2023 2024, 19 MVS used four patients transmural...

Abstract Background Familial polyposis syndromes such as Juvenille syndrome (JPS) and adenomatous (FAP) are associated with ∼21% ∼11% lifetime risk of foregut carcinoma respectively. In patients effected, routine oesophago-gastro-duodenoscopy (OGD) is recommended every 1-3 years, in JPS from 15 years old FAP 25 old. malignant transformation traditional resection Roux-en-Y reconstruction inhibits future duodenoscopy. Method Between April July 2024 two presented requiring total gastrostomy...

Abstract Background Chyle leak is a recognised complication of oesophagectomy associated with increased length hospital stay, morbidity and potentially fatal. management controversial, lacks standardised or validated approach. Interventional radiological approaches are well described routinely able to identify embolise these thoracic duct leaks reducing need for return theatre. The aim retrospectively evaluate outcomes lymphangio-embolisation in patients post Ivor Lewis oesophageal...

Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed late, leading to a high mortality rate. Early detection facilitates better treatment options. The aim of this UK-based case-control study was determine whether two validated tests for pancreatic exocrine insufficiency (PEI), namely, the 13C-mixed triglyceride breath test (13C-MTGBT) and faecal elastase (FE-1) test, can discriminate between patients with resectable PDAC versus healthy volunteers (HVs) along comparison group chronic...

Background: Cellulitis, or erysipelas can be defined as inflammation caused by infection of the dermal and subdermal tissues. Application CREST IDSA guidelines in management cellulitis is poorly studied it observed that current admission prescription practices Ireland vary widely adhere to guidelines. We aimed examine adherence these with regard hospital antimicrobial therapy.

An 83-year-old man presented to the emergency department (ED) with tachycardia, hypotension and in respiratory distress. Eleven days prior this he had undergone elective cardiac bypass surgery for angina. A chest radiograph was taken while ED (figure 1), shows a good example of Chilaiditi's sign, where bowel becomes interposed between liver diaphragm. He referred general surgeons who performed an laparotomy …

A 21-year-old man was taken to the emergency department after having fainted. He had hit his head and lost consciousness for a few seconds, friends witnessed shaking episode during this time, although there no tongue biting or incontinence. sustained small laceration above left eye following fall. On presentation, he worsening headache, felt dizzy anterograde amnaesia. Examination otherwise unremarkable. Given symptoms, it decided perform CT scan of …

A 30 year old woman presents to the emergency department complaining of a painful left middle finger that she first noticed previous night. She tells you had been bitten earlier in week by her pet hamster. You establish is hand dominant, non-smoker, and works as an artist. systemically well has no evidence pyrexia. inspect picture record your findings (see figure).⇓ Palpating digit along volar (palm) side aspect elicits tenderness, which made worse with passive extension (whereby examiner...